CMAUP Plant Collective Molecular Activities

Plant Name: Aconitum ciliare

Taxonomic Information:

Plant ID: NPO4893
Plant Latin Name: Aconitum ciliare
Taxonomy Genus: Aconitum
Taxonomy Family: Ranunculaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	DRD3; DRD4; DRD2;
Enzyme_unclassified	HSD17B10;
Transcription Factor	HIF1A;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Small molecule receptor (family A GPCR)	DRD3	Dopamine D3 receptor	P35462	CHEMBL234
Small molecule receptor (family A GPCR)	DRD4	Dopamine D4 receptor	P21917	CHEMBL219
Small molecule receptor (family A GPCR)	DRD2	Dopamine D2 receptor	P14416	CHEMBL217
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0060089; molecular transducer activity	GO:0001591; dopamine neurotransmitter receptor activity, coupled via Gi/Go	4.661E-10	3.383E-06	DRD2, DRD3, DRD4
BP	GO:0009987; cellular process	GO:0007195; adenylate cyclase-inhibiting dopamine receptor signaling pathway	9.986E-10	5.436E-06	DRD2, DRD3, DRD4
BP	GO:0050896; response to stimulus	GO:0034776; response to histamine	1.373E-09	5.980E-06	DRD2, DRD3, DRD4
MF	GO:0005488; binding	GO:0035240; dopamine binding	2.380E-09	7.402E-06	DRD2, DRD3, DRD4
BP	GO:0007610; behavior	GO:0048148; behavioral response to cocaine	9.480E-09	1.877E-05	DRD2, DRD3, DRD4
BP	GO:0051179; localization	GO:0050482; arachidonic acid secretion	1.472E-08	2.466E-05	DRD2, DRD3, DRD4
BP	GO:0050896; response to stimulus	GO:0001975; response to amphetamine	2.161E-08	3.137E-05	DRD2, DRD3, DRD4
BP	GO:0008152; metabolic process	GO:0042417; dopamine metabolic process	2.722E-08	3.673E-05	DRD2, DRD3, DRD4
BP	GO:0065007; biological regulation	GO:0007194; negative regulation of adenylate cyclase activity	4.121E-08	4.723E-05	DRD2, DRD3, DRD4
BP	GO:0007610; behavior	GO:0008542; visual learning	1.435E-07	9.079E-05	DRD2, DRD3, HIF1A
BP	GO:0009987; cellular process	GO:0060160; negative regulation of dopamine receptor signaling pathway	1.608E-07	9.079E-05	DRD2, DRD3
BP	GO:0023052; signaling	GO:0051586; positive regulation of dopamine uptake involved in synaptic transmission	1.608E-07	9.079E-05	DRD2, DRD4
BP	GO:0040011; locomotion	GO:0090325; regulation of locomotion involved in locomotory behavior	5.359E-07	2.334E-04	DRD2, DRD3
BP	GO:0051179; localization	GO:0002028; regulation of sodium ion transport	7.603E-07	2.854E-04	DRD2, DRD3, DRD4
BP	Unclassified;	GO:0032415; regulation of sodium:proton antiporter activity	8.038E-07	2.966E-04	DRD3, DRD4
BP	GO:0009987; cellular process	GO:0050709; negative regulation of protein secretion	2.376E-06	6.898E-04	DRD2, DRD3, DRD4
BP	GO:0009987; cellular process	GO:0002031; G-protein coupled receptor internalization	2.946E-06	7.941E-04	DRD2, DRD3
BP	GO:0050896; response to stimulus	GO:0060134; prepulse inhibition	4.177E-06	9.902E-04	DRD2, DRD3
BP	GO:0032501; multicellular organismal process	GO:0035815; positive regulation of renal sodium excretion	4.177E-06	9.902E-04	DRD2, DRD3
BP	GO:0007610; behavior	GO:0048149; behavioral response to ethanol	4.872E-06	1.141E-03	DRD2, DRD4
BP	GO:0051179; localization	GO:1901386; negative regulation of voltage-gated calcium channel activity	7.279E-06	1.569E-03	DRD2, DRD4
BP	GO:0007610; behavior	GO:0007626; locomotory behavior	7.720E-06	1.632E-03	DRD2, DRD3, DRD4
BP	GO:0032501; multicellular organismal process	GO:0045187; regulation of circadian sleep/wake cycle, sleep	9.151E-06	1.862E-03	DRD2, DRD3
BP	GO:0008283; cell proliferation	GO:0002052; positive regulation of neuroblast proliferation	1.017E-05	2.012E-03	DRD2, HIF1A
BP	GO:0009987; cellular process	GO:0014059; regulation of dopamine secretion	2.021E-05	3.438E-03	DRD2, DRD3
BP	GO:0050896; response to stimulus	GO:0010039; response to iron ion	2.485E-05	4.009E-03	DRD2, HIF1A
BP	GO:0050896; response to stimulus	GO:0043278; response to morphine	2.651E-05	4.123E-03	DRD2, DRD3
BP	GO:0048511; rhythmic process	GO:0048511; rhythmic process	3.077E-05	4.621E-03	DRD2, DRD3, DRD4
BP	GO:0065007; biological regulation	GO:0045776; negative regulation of blood pressure	4.596E-05	6.375E-03	DRD2, DRD3
BP	GO:0065007; biological regulation	GO:0006874; cellular calcium ion homeostasis	7.393E-05	9.757E-03	DRD2, DRD3, DRD4
MF	GO:0005488; binding	GO:0019904; protein domain specific binding	4.393E-04	4.328E-02	DRD3, DRD4, HIF1A
CC	GO:0044464; cell part	GO:0042995; cell projection	3.316E-03	1.867E-01	DRD2, DRD3, HIF1A
CC	GO:0044425; membrane part	GO:0005887; integral component of plasma membrane	3.463E-03	1.919E-01	DRD2, DRD3, DRD4

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09156 Nervous system	hsa04728	Dopaminergic synapse	2.597E-06	4.934E-05	DRD2, DRD3, DRD4
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	2.575E-05	2.446E-04	DRD2, DRD3, DRD4
09100 Metabolism	09105 Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1.194E-02	4.517E-02	HSD17B10
09160 Human Diseases	09164 Substance dependence	hsa05030	Cocaine addiction	1.219E-02	4.517E-02	DRD2
09130 Environmental Information Processing	09132 Signal transduction	hsa04150	mTOR signaling pathway	1.491E-02	4.517E-02	HIF1A
09160 Human Diseases	09161 Cancers	hsa05211	Renal cell carcinoma	1.639E-02	4.517E-02	HIF1A
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	1.664E-02	4.517E-02	HIF1A
09160 Human Diseases	09161 Cancers	hsa05231	Choline metabolism in cancer	2.500E-02	4.843E-02	HIF1A
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04540	Gap junction	2.181E-02	4.843E-02	DRD2
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	2.549E-02	4.843E-02	HIF1A

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Female sexual dysfunction	F52	DRD3;
K00-K95: Diseases of the digestive system	Gastric motility disorder	K22.4	DRD3;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Emesis	R11	DRD3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cocaine addiction	F14.2	DRD3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Male sexual disorders	F52	DRD3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	DRD3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	DRD3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Drug abuse	F10-F19	DRD3;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases