CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Phosphatase	PTPN1;
Enzyme_unclassified	TDP1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway	4.141E-04	1.000E+00	PTPN1
BP	GO:0009987; cellular process	GO:0035791; platelet-derived growth factor receptor-beta signaling pathway	6.212E-04	1.000E+00	PTPN1
BP	GO:0050896; response to stimulus	GO:0060397; JAK-STAT cascade involved in growth hormone signaling pathway	1.553E-03	1.000E+00	PTPN1
BP	GO:0050896; response to stimulus	GO:0046627; negative regulation of insulin receptor signaling pathway	3.104E-03	1.000E+00	PTPN1
BP	Unclassified;	GO:0061098; positive regulation of protein tyrosine kinase activity	4.447E-03	1.000E+00	PTPN1
BP	GO:0009987; cellular process	GO:0060338; regulation of type I interferon-mediated signaling pathway	4.757E-03	1.000E+00	PTPN1
BP	GO:0009987; cellular process	GO:0006302; double-strand break repair	1.763E-02	1.000E+00	TDP1
BP	GO:0051179; localization	GO:0030100; regulation of endocytosis	2.255E-02	1.000E+00	PTPN1
CC	GO:0044464; cell part	GO:0097443; sorting endosome	6.212E-04	1.000E+00	PTPN1
MF	GO:0005488; binding	GO:0051721; protein phosphatase 2A binding	2.897E-03	1.000E+00	PTPN1

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	7.386E-03	1.385E-02	PTPN1
09150 Organismal Systems	09152 Endocrine system	hsa04910	Insulin signaling pathway	1.385E-02	1.385E-02	PTPN1
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	1.087E-02	1.385E-02	PTPN1

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Salvia divaricata

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities