CMAUP Plant Collective Molecular Activities

Plant Name: Tabebuia avellanedae

Taxonomic Information:

Plant ID: NPO487
Plant Latin Name: Tabebuia avellanedae
Taxonomy Genus: Tabebuia
Taxonomy Family: Bignoniaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

United States; China

Traditional Medicine System:

TCM

Geographical Distribution:

United States; China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR; NPSR1;
Small molecule receptor (family A GPCR)	GPR35;
Enzyme_unclassified	TDP2; GLA; TDP1; IDO1; ALDH1A1;
Lyase	CA2; CA1; CA12; CA9; CA5B; CA5A; CA14; CA7; CA4; CA6;
Lysine demethylase	KDM4E;
Hydrolase	MALT1;
Transcription Factor	TP53; NFKB1;
Unclassified	HTT; THPO;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C19; CYP1A2; CYP2A6;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2A6	Cytochrome P450 2A6	P11509	CHEMBL5282
Enzyme_unclassified	TDP2	Tyrosyl-DNA phosphodiesterase 2	O95551	CHEMBL2169736
Enzyme_unclassified	GLA	Alpha-galactosidase A	P06280	CHEMBL2524
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	IDO1	Indoleamine 2,3-dioxygenase	P14902	CHEMBL4685
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Hydrolase	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9UDY8	CHEMBL3632452
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Small molecule receptor (family A GPCR)	GPR35	G-protein coupled receptor 35	Q9HC97	CHEMBL1293267
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.596E-07	3.160E-04	CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, TP53
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	3.012E-26	6.559E-22	CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	6.633E-07	1.204E-03	CYP1A2, CYP2A6, CYP2C19
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	3.974E-06	6.180E-03	CYP1A2, CYP2A6, CYP2C19
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	6.523E-06	9.470E-03	CA2, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.425E-20	2.640E-16	CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	8.929E-19	4.861E-15	CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	3.252E-05	3.219E-02	CA1, CA2
MF	GO:0005488; binding	GO:0020037; heme binding	3.843E-05	3.487E-02	CYP1A2, CYP2A6, CYP2C19, IDO1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.375E-25	1.375E-23	CA12, CA1, CA5B, CA2, CA5A, CA4, CA7, CA6, CA9, CA14
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.127E-04	3.366E-03	CYP2A6, CYP1A2, ALDH1A1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.347E-04	3.366E-03	CYP2A6, CYP1A2, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.247E-04	4.495E-03	CYP2A6, CYP1A2, CYP2C19
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	2.025E-05	1.012E-03	CYP2A6, CYP1A2
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	1.530E-03	1.913E-02	CYP1A2, IDO1
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	5.040E-04	8.400E-03	CA2, CA4
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	8.044E-04	1.149E-02	CYP1A2, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	5.006E-03	4.171E-02	TP53, NFKB1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5.006E-03	4.171E-02	CYP2A6, CYP1A2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Cancer	C00-C96	IDO1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	IDO1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases