Plant Name: Piper kadsura
Taxonomic Information:
Plant ID: NPO4865
Plant Latin Name: Piper kadsura
Taxonomy Genus: Piper
Taxonomy Family: Piperaceae
Plant External Links:
NCBI TaxonomyDB:
54803
Plant-of-the-World-Online:
681817-1
Used in Medicines:
Unknown.
Geographical Distribution:
Japan; Taiwan; South Africa
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| PTAFR; | |
| CDK2; MAPK9; AURKB; AURKA; CDK1; CDK4; | |
| HMGCR; | |
| MMP3; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Metallo protease | MMP3 | Matrix metalloproteinase 3 | P08254 | CHEMBL283 |
| Oxidoreductase | HMGCR | HMG-CoA reductase | P04035 | CHEMBL402 |
| Protein Kinase | CDK2 | Cyclin-dependent kinase 2 | P24941 | CHEMBL301 |
| Protein Kinase | MAPK9 | c-Jun N-terminal kinase 2 | P45984 | CHEMBL4179 |
| Protein Kinase | AURKB | Serine/threonine-protein kinase Aurora-B | Q96GD4 | CHEMBL2185 |
| Protein Kinase | AURKA | Serine/threonine-protein kinase Aurora-A | O14965 | CHEMBL4722 |
| Protein Kinase | CDK1 | Cyclin-dependent kinase 1 | P06493 | CHEMBL308 |
| Protein Kinase | CDK4 | Cyclin-dependent kinase 4 | P11802 | CHEMBL331 |
| Small molecule receptor (family A GPCR) | PTAFR | Platelet activating factor receptor | P25105 | CHEMBL250 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0005488; binding | GO:0030332; cyclin binding | 3.123E-07 | 3.401E-04 | CDK1, CDK2, CDK4 |
| MF | GO:0003824; catalytic activity | GO:0004693; cyclin-dependent protein serine/threonine kinase activity | 4.544E-07 | 4.455E-04 | CDK1, CDK2, CDK4 |
| CC | GO:0044464; cell part | GO:0000307; cyclin-dependent protein kinase holoenzyme complex | 7.390E-07 | 5.960E-04 | CDK1, CDK2, CDK4 |
| CC | GO:0043226; organelle | GO:0005876; spindle microtubule | 1.620E-06 | 9.531E-04 | AURKA, AURKB, CDK1 |
| CC | GO:0032991; macromolecular complex | GO:0032133; chromosome passenger complex | 1.928E-06 | 1.077E-03 | AURKA, AURKB |
| BP | GO:0009987; cellular process | GO:0006977; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | 2.609E-06 | 1.217E-03 | AURKA, CDK1, CDK2 |
| MF | GO:0003824; catalytic activity | GO:0035174; histone serine kinase activity | 2.892E-06 | 1.259E-03 | AURKA, AURKB |
| BP | GO:0032502; developmental process | GO:0031100; animal organ regeneration | 4.834E-06 | 1.856E-03 | AURKA, CDK1, CDK4 |
| BP | GO:0008152; metabolic process | GO:0031145; anaphase-promoting complex-dependent catabolic process | 5.644E-06 | 1.920E-03 | AURKA, AURKB, CDK1 |
| BP | GO:0065007; biological regulation | GO:0065009; regulation of molecular function | 6.366E-06 | 2.133E-03 | AURKA, AURKB, CDK1, CDK2, CDK4, HMGCR, MAPK9, PTAFR |
| BP | GO:0009987; cellular process | GO:0010972; negative regulation of G2/M transition of mitotic cell cycle | 9.179E-06 | 2.738E-03 | AURKA, AURKB, CDK1 |
| BP | GO:0008152; metabolic process | GO:0035404; histone-serine phosphorylation | 1.271E-05 | 3.455E-03 | AURKA, AURKB |
| CC | GO:0043226; organelle | GO:0000780; condensed nuclear chromosome, centromeric region | 1.271E-05 | 3.455E-03 | AURKA, AURKB |
| CC | GO:0043226; organelle | GO:0031616; spindle pole centrosome | 1.271E-05 | 3.455E-03 | AURKA, AURKB |
| MF | GO:0005488; binding | GO:0005524; ATP binding | 1.359E-05 | 3.522E-03 | AURKA, AURKB, CDK1, CDK2, CDK4, MAPK9 |
| BP | GO:0051179; localization | GO:0034501; protein localization to kinetochore | 1.501E-05 | 3.681E-03 | AURKB, CDK1 |
| BP | GO:0009987; cellular process | GO:0042981; regulation of apoptotic process | 1.539E-05 | 3.681E-03 | AURKA, AURKB, CDK1, CDK4, HMGCR, MAPK9 |
| BP | GO:0008283; cell proliferation | GO:0008284; positive regulation of cell proliferation | 2.180E-05 | 4.747E-03 | CDK1, CDK2, CDK4, HMGCR, PTAFR |
| BP | GO:0009987; cellular process | GO:0045931; positive regulation of mitotic cell cycle | 3.298E-05 | 6.249E-03 | AURKA, CDK1, CDK4 |
| BP | GO:0050896; response to stimulus | GO:0009628; response to abiotic stimulus | 4.010E-05 | 7.301E-03 | AURKB, CDK4, HMGCR, MAPK9, PTAFR |
| BP | GO:0009987; cellular process | GO:1901796; regulation of signal transduction by p53 class mediator | 6.000E-05 | 9.678E-03 | AURKA, AURKB, CDK2 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04115 | p53 signaling pathway | 3.253E-06 | 2.309E-04 | CDK4, CDK2, CDK1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04914 | Progesterone-mediated oocyte maturation | 9.381E-06 | 3.330E-04 | MAPK9, CDK2, CDK1 |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04114 | Oocyte meiosis | 1.856E-05 | 3.375E-04 | CDK2, CDK1, AURKA |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05161 | Hepatitis B | 3.100E-05 | 4.402E-04 | MAPK9, CDK4, CDK2 |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04110 | Cell cycle | 1.902E-05 | 3.375E-04 | CDK4, CDK2, CDK1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05169 | Epstein-Barr virus infection | 8.153E-05 | 7.560E-04 | MAPK9, CDK2, CDK1 |
| 09160 Human Diseases | 09161 Cancers | hsa05203 | Viral carcinogenesis | 8.518E-05 | 7.560E-04 | CDK4, CDK2, CDK1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05168 | Herpes simplex infection | 6.279E-05 | 7.430E-04 | MAPK9, CDK2, CDK1 |
| 09160 Human Diseases | 09161 Cancers | hsa05200 | Pathways in cancer | 5.965E-04 | 4.164E-03 | MAPK9, CDK4, CDK2 |
| 09160 Human Diseases | 09161 Cancers | hsa05212 | Pancreatic cancer | 3.804E-04 | 3.001E-03 | MAPK9, CDK4 |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 8.883E-04 | 5.142E-03 | MAPK9, CDK4 |
| 09160 Human Diseases | 09161 Cancers | hsa05222 | Small cell lung cancer | 6.452E-04 | 4.164E-03 | CDK4, CDK2 |
| 09150 Organismal Systems | 09151 Immune system | hsa04660 | T cell receptor signaling pathway | 9.414E-04 | 5.142E-03 | MAPK9, CDK4 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04668 | TNF signaling pathway | 1.052E-03 | 5.337E-03 | MAPK9, MMP3 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04068 | FoxO signaling pathway | 1.533E-03 | 7.107E-03 | MAPK9, CDK2 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05162 | Measles | 1.602E-03 | 7.107E-03 | CDK4, CDK2 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| J00-J99: Diseases of the respiratory system | Asthma | J45 | PTAFR; |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | PTAFR; |
| K00-K95: Diseases of the digestive system | Inflammatory bowel disease | K50, K51 | PTAFR; |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | CDK2; |
| I00-I99: Diseases of the circulatory system | Ischemic stroke | I61-I63 | MMP3; |
| A00-B99: Certain infectious and parasitic diseases | HCV infection | B17.1, B18.2 | MMP3; |
| A00-B99: Certain infectious and parasitic diseases | Septic shock | A41.9 | PTAFR; |
| C00-D49: Neoplasms | Breast cancer | C50 | CDK1; |
| G00-G99: Diseases of the nervous system G00-G99 | Brain ischaemia | G45.9, I67.8 | PTAFR; |
| I00-I99: Diseases of the circulatory system | Cardiac arrhythmias | I47-I49 | PTAFR; |
| C00-D49: Neoplasms | Acute lymphoblastic leukemia | C91.0 | CDK2; |
| C00-D49: Neoplasms | Cancer | C00-C96 | CDK2; CDK1; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Allergy | T78.4 | PTAFR; |
| L00-L99: Diseases of the skin and subcutaneous tissue | Psoriasis | L40 | PTAFR; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | MMP3; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Osteoarthritis | M15-M19, M47 | MMP3; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | CDK2; PTAFR; |
| H00-H59: Diseases of the eye and adnexa | Ocular allergy | H00-H59 | PTAFR; |
| I00-I99: Diseases of the circulatory system | Stroke | I61-I63, I80-I82 | PTAFR; |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | CDK1; PTAFR; |
| I00-I99: Diseases of the circulatory system | Cerebral infarction | I63 | PTAFR; |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Thrombocytopenia | D69.6, P61.0 | PTAFR; |
| I00-I99: Diseases of the circulatory system | Thromboembolism | I80-I82 | PTAFR; |
| C00-D49: Neoplasms | Thymoma | C37, D15.0 | CDK2; |
| H00-H59: Diseases of the eye and adnexa | Corneal ulcers | H16.0 | MMP3; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Nerve injury | T14.4 | PTAFR; |
| I00-I99: Diseases of the circulatory system | Myocardial infarction | I21, I22 | MMP3; |
| H00-H59: Diseases of the eye and adnexa | Conjunctivitis | H10 | PTAFR; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
