CMAUP Plant Collective Molecular Activities

Plant Name: Dioscorea futschauensis

Taxonomic Information:

Plant ID: NPO4863
Plant Latin Name: Dioscorea futschauensis
Taxonomy Genus: Dioscorea
Taxonomy Family: Dioscoreaceae

Plant External Links:

NCBI TaxonomyDB: 374971
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	HKDC1; ALOX12; ALOX15; HPGD; AKR1B1; USP2;
Lysine demethylase	KDM4E;
SLC superfamily of solute carriers	SLCO1B3;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Enzyme_unclassified	HKDC1	Putative hexokinase HKDC1	Q2TB90	CHEMBL1741200
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	USP2	Ubiquitin carboxyl-terminal hydrolase 2	O75604	CHEMBL1293227
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
SLC superfamily of solute carriers	SLCO1B3	Solute carrier organic anion transporter family member 1B3	Q9NPD5	CHEMBL1743121

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0019372; lipoxygenase pathway	7.663E-08	8.025E-04	ALOX12, ALOX15, HPGD
BP	GO:0008152; metabolic process	GO:2001303; lipoxin A4 biosynthetic process	2.948E-07	8.025E-04	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0047977; hepoxilin-epoxide hydrolase activity	2.948E-07	8.025E-04	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0004052; arachidonate 12-lipoxygenase activity	8.842E-07	1.925E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0051120; hepoxilin A3 synthase activity	8.842E-07	1.925E-03	ALOX12, ALOX15
BP	GO:0008152; metabolic process	GO:0051122; hepoxilin biosynthetic process	2.946E-06	4.581E-03	ALOX12, ALOX15
BP	GO:0008152; metabolic process	GO:0019369; arachidonic acid metabolic process	3.354E-06	4.806E-03	ALOX12, ALOX15, CYP1A2
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	3.752E-06	4.806E-03	AKR1B1, ALOX12, ALOX15, CYP1A2, HPGD, KDM4E
MF	GO:0003824; catalytic activity	GO:0051213; dioxygenase activity	1.571E-05	1.699E-02	ALOX12, ALOX15, KDM4E
CC	GO:0043226; organelle	GO:0097504; Gemini of coiled bodies	1.940E-05	1.837E-02	SMN1, SMN2
CC	GO:0032991; macromolecular complex	GO:0032797; SMN complex	2.292E-05	1.996E-02	SMN1, SMN2
CC	GO:0044464; cell part	GO:0034719; SMN-Sm protein complex	4.489E-05	3.759E-02	SMN1, SMN2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.108E-04	1.307E-03	CYP1A2, ALOX15
Unclassified	Unclassified	hsa01100	Metabolic pathways	3.052E-04	2.212E-03	HKDC1, CYP1A2, ALOX15, AKR1B1, ALOX12
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	1.186E-04	1.307E-03	HKDC1, AKR1B1
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	5.108E-04	2.962E-03	ALOX15, ALOX12
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1.352E-04	1.307E-03	HKDC1, AKR1B1
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.654E-03	7.994E-03	ALOX15, ALOX12
09120 Genetic Information Processing	09122 Translation	hsa03013	RNA transport	3.843E-03	1.238E-02	SMN2, SMN1
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	3.837E-02	4.972E-02	SLCO1B3
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	2.747E-03	9.959E-03	CYP1A2
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00524	Butirosin and neomycin biosynthesis	2.747E-03	9.959E-03	HKDC1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases