Plant Name: Cassia roxburghii
Taxonomic Information:
Plant ID: NPO4776
Plant Latin Name: Cassia roxburghii
Taxonomy Genus: Cassia
Taxonomy Family: Fabaceae
Plant External Links:
NCBI TaxonomyDB:
948717
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| MAPK1; | |
| NR1H4; | |
| USP2; | |
| MAPT; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: | CYP3A4; |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Enzyme_unclassified | USP2 | Ubiquitin carboxyl-terminal hydrolase 2 | O75604 | CHEMBL1293227 |
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:1900034; regulation of cellular response to heat | 1.597E-04 | 1.879E-01 | MAPK1, MAPT |
| BP | GO:0007610; behavior | GO:0007610; behavior | 2.083E-04 | 1.879E-01 | MAPK1, MAPT, USP2 |
| CC | GO:0044464; cell part | GO:0032838; plasma membrane bounded cell projection cytoplasm | 1.177E-04 | 1.879E-01 | MAPK1, MAPT |
| CC | GO:0044464; cell part | GO:0030424; axon | 1.717E-03 | 4.286E-01 | MAPK1, MAPT |
| CC | GO:0044464; cell part | GO:0030673; axolemma | 4.135E-03 | 5.924E-01 | MAPT |
| CC | Unclassified; | GO:0031143; pseudopodium | 4.393E-03 | 6.055E-01 | MAPK1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 1.234E-04 | 1.172E-02 | NR1H4, CYP3A4 |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05010 | Alzheimer's disease | 6.899E-04 | 3.277E-02 | MAPK1, MAPT |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00140 | Steroid hormone biosynthesis | 1.442E-02 | 4.307E-02 | CYP3A4 |
| 09160 Human Diseases | 09161 Cancers | hsa05212 | Pancreatic cancer | 1.639E-02 | 4.307E-02 | MAPK1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04664 | Fc epsilon RI signaling pathway | 1.689E-02 | 4.307E-02 | MAPK1 |
| 09100 Metabolism | 09108 Metabolism of cofactors and vitamins | hsa00830 | Retinol metabolism | 1.615E-02 | 4.307E-02 | CYP3A4 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04720 | Long-term potentiation | 1.639E-02 | 4.307E-02 | MAPK1 |
| 09160 Human Diseases | 09161 Cancers | hsa05211 | Renal cell carcinoma | 1.639E-02 | 4.307E-02 | MAPK1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05131 | Shigellosis | 1.615E-02 | 4.307E-02 | MAPK1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04917 | Prolactin signaling pathway | 1.787E-02 | 4.307E-02 | MAPK1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
