CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Kinase	MAPK1;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Enzyme_unclassified	USP2;
Unclassified	MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	USP2	Ubiquitin carboxyl-terminal hydrolase 2	O75604	CHEMBL1293227
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Showing 1 to 5 of 5 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:1900034; regulation of cellular response to heat	1.597E-04	1.879E-01	MAPK1, MAPT
BP	GO:0007610; behavior	GO:0007610; behavior	2.083E-04	1.879E-01	MAPK1, MAPT, USP2
CC	GO:0044464; cell part	GO:0032838; plasma membrane bounded cell projection cytoplasm	1.177E-04	1.879E-01	MAPK1, MAPT
CC	GO:0044464; cell part	GO:0030424; axon	1.717E-03	4.286E-01	MAPK1, MAPT
CC	GO:0044464; cell part	GO:0030673; axolemma	4.135E-03	5.924E-01	MAPT
CC	Unclassified;	GO:0031143; pseudopodium	4.393E-03	6.055E-01	MAPK1

Showing 1 to 6 of 6 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.442E-02	4.307E-02	CYP3A4
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.615E-02	4.307E-02	CYP3A4
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	1.234E-04	1.172E-02	NR1H4, CYP3A4
09150 Organismal Systems	09151 Immune system	hsa04664	Fc epsilon RI signaling pathway	1.689E-02	4.307E-02	MAPK1
09150 Organismal Systems	09156 Nervous system	hsa04720	Long-term potentiation	1.639E-02	4.307E-02	MAPK1
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	1.787E-02	4.307E-02	MAPK1
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	6.899E-04	3.277E-02	MAPK1, MAPT
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	1.639E-02	4.307E-02	MAPK1
09160 Human Diseases	09161 Cancers	hsa05211	Renal cell carcinoma	1.639E-02	4.307E-02	MAPK1
09160 Human Diseases	09167 Infectious diseases	hsa05131	Shigellosis	1.615E-02	4.307E-02	MAPK1

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
No data available in table

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Cassia roxburghii

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities