CMAUP Plant Collective Molecular Activities

Plant Name: Uncaria elliptica

Taxonomic Information:

Plant ID: NPO4763
Plant Latin Name: Uncaria elliptica
Taxonomy Genus: Uncaria
Taxonomy Family: Rubiaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADRA2C; ADRA2A; ADRA2B;
Peptide receptor (family A GPCR)	NPSR1;
Enzyme_unclassified	P4HB; AKR1B1; POLB;
Lysine demethylase	KDM4E;
Transcription Factor	NFKB1; HIF1A;
Unclassified	MAPT; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP3A4; CYP2D6; CYP2C9;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	P4HB	Protein disulfide-isomerase	P07237	CHEMBL5422
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Small molecule receptor (family A GPCR)	ADRA2C	Alpha-2c adrenergic receptor	P18825	CHEMBL1916
Small molecule receptor (family A GPCR)	ADRA2A	Alpha-2a adrenergic receptor	P08913	CHEMBL1867
Small molecule receptor (family A GPCR)	ADRA2B	Alpha-2b adrenergic receptor	P18089	CHEMBL1942
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	4.703E-12	1.024E-07	CYP1A2, CYP2C9, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	1.547E-10	1.685E-06	CYP1A2, CYP2C9, CYP2D6, CYP3A4
MF	GO:0060089; molecular transducer activity	GO:0004938; alpha2-adrenergic receptor activity	4.663E-10	3.384E-06	ADRA2A, ADRA2B, ADRA2C
BP	GO:0065007; biological regulation	GO:0035625; epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway	1.864E-09	5.074E-06	ADRA2A, ADRA2B, ADRA2C
BP	GO:0009987; cellular process	GO:0032811; negative regulation of epinephrine secretion	1.864E-09	5.074E-06	ADRA2A, ADRA2B, ADRA2C
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	1.864E-09	5.074E-06	CYP1A2, CYP2C9, CYP3A4
BP	GO:0009987; cellular process	GO:0010700; negative regulation of norepinephrine secretion	2.605E-08	4.051E-05	ADRA2A, ADRA2B, ADRA2C
MF	GO:0005488; binding	GO:0051379; epinephrine binding	2.605E-08	4.051E-05	ADRA2A, ADRA2B, ADRA2C
MF	GO:0005488; binding	GO:0019825; oxygen binding	4.582E-08	6.236E-05	CYP1A2, CYP2C9, CYP2D6, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	1.021E-07	1.170E-04	CYP1A2, CYP2C9, CYP3A4
BP	GO:0009987; cellular process	GO:0071880; adenylate cyclase-activating adrenergic receptor signaling pathway	5.270E-07	4.590E-04	ADRA2A, ADRA2B, ADRA2C
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	8.175E-07	6.593E-04	CYP1A2, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	1.929E-06	1.167E-03	CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	1.983E-06	1.167E-03	CYP1A2, CYP2C9, CYP2D6, CYP3A4
BP	GO:0065007; biological regulation	GO:0032148; activation of protein kinase B activity	2.747E-06	1.495E-03	ADRA2A, ADRA2B, ADRA2C
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	2.747E-06	1.495E-03	CYP2C9, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0020037; heme binding	3.148E-06	1.632E-03	CYP1A2, CYP2C9, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0005506; iron ion binding	7.636E-06	3.342E-03	CYP1A2, CYP2C9, CYP2D6, CYP3A4
BP	Unclassified;	GO:0019229; regulation of vasoconstriction	1.550E-05	6.138E-03	ADRA2A, ADRA2B, ADRA2C
CC	GO:0044464; cell part	GO:0032838; plasma membrane bounded cell projection cytoplasm	2.163E-05	8.119E-03	AKR1B1, HIF1A, MAPT
BP	GO:0009987; cellular process	GO:0019896; axonal transport of mitochondrion	2.308E-05	8.376E-03	HIF1A, MAPT

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2.288E-07	1.193E-05	CYP2C9, CYP2D6, CYP1A2, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2.875E-07	1.193E-05	CYP2C9, CYP2D6, CYP1A2, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.516E-06	4.193E-05	CYP2C9, CYP1A2, CYP3A4
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.780E-05	3.694E-04	CYP2C9, CYP1A2, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	3.579E-05	5.942E-04	CYP2C9, CYP1A2, CYP3A4
09130 Environmental Information Processing	09132 Signal transduction	hsa04022	cGMP-PKG signaling pathway	2.956E-04	4.089E-03	ADRA2C, ADRA2B, ADRA2A
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1.288E-03	1.336E-02	ADRA2C, ADRA2B, ADRA2A
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	9.663E-04	1.146E-02	CYP1A2, CYP3A4
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	3.007E-03	2.773E-02	HIF1A, NFKB1
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	3.543E-03	2.941E-02	CYP2C9, CYP2D6

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	ADRA2B; ADRA2C;
K00-K95: Diseases of the digestive system	Peptic ulcer	K25-K27	ADRA2C;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ADRA2A; ADRA2C;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Fibromyalgia	M79.7	ADRA2C;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Male sexual disorders	F52	ADRA2C;
I00-I99: Diseases of the circulatory system	Hypotension	I95	ADRA2C;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Attention deficit hyperactivity disorder	F90	ADRA2A;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CYP2D6;
J00-J99: Diseases of the respiratory system	Asthma	J45	ADRA2C;
S00-T88: Injury, poisoning and certain other consequences of external causes	Contusion	S36.220S	ADRA2C;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sexual dysfunction	F52	ADRA2A;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ADRA2C;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	ADRA2C;
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	ADRA2C;
L00-L99: Diseases of the skin and subcutaneous tissue	Erythema	L51-L54	ADRA2C;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	ADRA2C;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	ADRA2B;
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	CYP2D6;
I00-I99: Diseases of the circulatory system	Heart failure	I50	ADRA2C;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ADRA2C;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ADRA2C; MAPT;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	ADRA2C;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	ADRA2C;
H00-H59: Diseases of the eye and adnexa	Ocular disease	H00-H59	ADRA2C;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT;
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	ADRA2C;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	ADRA2C;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases