CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	NPSR1;
Protein Kinase	IGF1R; FLT3; AURKB; CDK1; MET; AXL; PIM1; KDR;
Lyase	CA7; CA4; CA12;
Enzyme_unclassified	ALOX12; NOX4; HSD17B10; POLB;
Metallo protease	MMP12;
Transcription Factor	HIF1A;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Metallo protease	MMP12	Matrix metalloproteinase 12	P39900	CHEMBL4393
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0018108; peptidyl-tyrosine phosphorylation	8.176E-07	8.549E-04	AXL, FLT3, IGF1R, KDR, MET
BP	GO:0008283; cell proliferation	GO:0008284; positive regulation of cell proliferation	9.215E-07	8.549E-04	ALOX12, CDK1, FLT3, HIF1A, IGF1R, KDR, MMP12, PIM1
BP	GO:0008152; metabolic process	GO:0046777; protein autophosphorylation	1.059E-06	9.223E-04	AURKB, FLT3, IGF1R, KDR, PIM1
BP	GO:0065007; biological regulation	GO:0048872; homeostasis of number of cells	4.464E-06	2.777E-03	AXL, FLT3, HIF1A, POLB
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	5.644E-06	2.997E-03	CA12, CA4, CA7
BP	GO:0009987; cellular process	GO:0001961; positive regulation of cytokine-mediated signaling pathway	9.713E-06	4.807E-03	AXL, HIF1A, MMP12
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.042E-05	4.931E-03	CA12, CA4, CA7
BP	GO:0032502; developmental process	GO:0045766; positive regulation of angiogenesis	1.372E-05	5.513E-03	ALOX12, CYP1B1, HIF1A, KDR
BP	GO:0065007; biological regulation	GO:0048878; chemical homeostasis	1.996E-05	7.367E-03	ALOX12, CA12, CA7, HIF1A, MET, NOX4, NPSR1
BP	GO:0009987; cellular process	GO:1902533; positive regulation of intracellular signal transduction	2.476E-05	8.695E-03	AXL, CDK1, CYP1B1, FLT3, KDR, MET, NOX4

Showing 1 to 10 of 14 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	4.901E-07	2.843E-05	CA12, CA4, CA7
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	9.902E-04	7.390E-03	KDR, MET, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	1.222E-03	7.672E-03	KDR, MET, IGF1R
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	1.905E-03	8.465E-03	FLT3, KDR, MET
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04510	Focal adhesion	8.730E-04	7.390E-03	KDR, MET, IGF1R
09140 Cellular Processes	09141 Transport and catabolism	hsa04144	Endocytosis	1.784E-03	8.465E-03	KDR, MET, IGF1R
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	2.217E-03	8.573E-03	MET, IGF1R
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	1.019E-03	7.390E-03	CYP1B1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	3.544E-05	6.852E-04	KDR, HIF1A, MET, IGF1R
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	3.351E-05	6.852E-04	FLT3, MET, HIF1A

Showing 1 to 10 of 16 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	IGF1R; KDR; FLT3;
C00-D49: Neoplasms	AML	NA	KDR; FLT3;
C00-D49: Neoplasms	Gastric cancer	C16	KDR;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR;
C00-D49: Neoplasms	Melanoma	C43	KDR;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Renal cancer	C64	KDR;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Lippia sidoides

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities