CMAUP Plant Collective Molecular Activities

Plant Name: Helianthus annuus

Taxonomic Information:

Plant ID: NPO454
Plant Latin Name: Helianthus annuus
Taxonomy Genus: Helianthus
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: 4232
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Indonesia; India; China; Chile; Thailand; Argentina

Traditional Medicine System:

Unani; TCM; Homeopathy; Ayurveda; Siddha

Medicinal Functions:

Antipsoriatic; Antirheumatic; Diuretic; Expectorant; Febrifuge; Stomachic

Geographical Distribution:

Indonesia; India; China; Chile; Thailand; Argentina

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	DRD1;
Peptide receptor (family A GPCR)	TSHR;
Oxidoreductase	MAOA;
Transcription Factor	AHR;
Enzyme_unclassified	UBE2N;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP2D6; CYP2C19; CYP19A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Enzyme_unclassified	UBE2N	Ubiquitin-conjugating enzyme E2 N	P61088	CHEMBL6089
Oxidoreductase	MAOA	Monoamine oxidase A	P21397	CHEMBL1951
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Small molecule receptor (family A GPCR)	DRD1	Dopamine D1 receptor	P21728	CHEMBL2056
Transcription Factor	AHR	Aryl hydrocarbon receptor	P35869	CHEMBL3201
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.997E-09	4.348E-05	CYP1A2, CYP2C19, CYP2D6
MF	GO:0005488; binding	GO:0019825; oxygen binding	5.341E-09	5.815E-05	CYP19A1, CYP1A2, CYP2C19, CYP2D6
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	2.351E-07	8.031E-04	AHR, CYP1A2, CYP2C19, CYP2D6
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	1.760E-07	8.031E-04	CYP19A1, CYP1A2, CYP2D6
MF	GO:0005488; binding	GO:0020037; heme binding	3.746E-07	1.020E-03	CYP19A1, CYP1A2, CYP2C19, CYP2D6
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	5.929E-07	1.291E-03	CYP19A1, CYP2C19, CYP2D6
MF	GO:0005488; binding	GO:0005506; iron ion binding	9.160E-07	1.662E-03	CYP19A1, CYP1A2, CYP2C19, CYP2D6
BP	GO:0008152; metabolic process	GO:0009820; alkaloid metabolic process	5.059E-06	7.021E-03	CYP1A2, CYP2D6
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	5.159E-06	7.021E-03	CYP19A1, CYP1A2, CYP2C19, CYP2D6
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.083E-05	1.387E-02	CYP1A2, CYP2C19
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	5.026E-05	3.919E-02	CYP19A1, CYP1A2, CYP2C19, CYP2D6, DRD1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2.682E-08	9.386E-07	MAOA, CYP2D6, CYP1A2, CYP2C19
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.994E-05	3.489E-04	CYP2D6, MAOA, CYP2C19
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	1.737E-04	1.520E-03	MAOA, CYP1A2
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	9.070E-05	1.058E-03	CYP1A2, CYP2C19
09160 Human Diseases	09164 Substance dependence	hsa05030	Cocaine addiction	2.613E-04	1.829E-03	MAOA, DRD1
09160 Human Diseases	09164 Substance dependence	hsa05031	Amphetamine addiction	4.889E-04	2.445E-03	MAOA, DRD1
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3.664E-04	2.138E-03	CYP1A2, CYP19A1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5.802E-04	2.539E-03	CYP2D6, CYP1A2
Unclassified	Unclassified	hsa01100	Metabolic pathways	2.276E-03	7.241E-03	MAOA, CYP1A2, CYP2C19, CYP19A1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	7.315E-04	2.845E-03	CYP1A2, CYP2C19
09150 Organismal Systems	09156 Nervous system	hsa04728	Dopaminergic synapse	1.796E-03	6.285E-03	MAOA, DRD1
09160 Human Diseases	09164 Substance dependence	hsa05034	Alcoholism	3.419E-03	9.206E-03	MAOA, DRD1
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	2.498E-03	7.285E-03	CYP1A2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cocaine addiction	F14.2	DRD1;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	DRD1;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	DRD1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychiatric disorder	F01-F99	DRD1;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CYP2D6;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	DRD1;
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	CYP2D6;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Substance dependence	F10-F19	DRD1;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	DRD1;
O00-O9A: Pregnancy, childbirth and the puerperium	Excessive bleeding following childbirth and spontaneous or elective abortion	O04	DRD1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases