CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Lyase	CA12; CA7;
Nuclear hormone receptor subfamily 3 group C	NR3C1;
Oxidoreductase	TYR;
Enzyme_unclassified	HSD17B2;
Transcription Factor	AHR; HIF1A;
Unclassified	PAX8; RAB9A; LMNA; NPC1;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP3A4; CYP1A1; CYP1A2;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	HSD17B2	Estradiol 17-beta-dehydrogenase 2	P37059	CHEMBL2789
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 3 group C	NR3C1	Glucocorticoid receptor	P04150	CHEMBL2034
Oxidoreductase	TYR	Tyrosinase	P14679	CHEMBL1973

Showing 1 to 10 of 16 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	6.769E-08	2.106E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	7.457E-07	1.624E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	9.919E-07	1.661E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	4.370E-06	3.660E-03	CYP1A1, CYP1A2
BP	GO:0008152; metabolic process	GO:0002933; lipid hydroxylation	1.091E-05	7.666E-03	CYP1A1, CYP3A4
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.091E-05	7.666E-03	CYP1A2, CYP3A4
BP	GO:0032502; developmental process	GO:0048856; anatomical structure development	1.254E-05	8.535E-03	AHR, CYP1A1, CYP1A2, CYP1B1, HIF1A, HSD17B2, LMNA, PAX8, SMN1, SMN2, TYR
BP	GO:0008152; metabolic process	GO:0009820; alkaloid metabolic process	1.527E-05	9.236E-03	CYP1A2, CYP3A4
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	3.597E-09	6.602E-05	CYP1A1, CYP1A2, CYP1B1, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	5.982E-08	2.106E-04	CYP1A1, CYP1A2, CYP1B1, CYP3A4

Showing 1 to 10 of 16 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.036E-09	3.626E-08	CYP1A2, HSD17B2, CYP1A1, CYP1B1, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3.750E-07	6.562E-06	CYP1A2, CYP1A1, CYP1B1, CYP3A4
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	4.943E-06	4.325E-05	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.157E-05	1.258E-04	CYP1A2, CYP1A1, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	2.724E-04	1.192E-03	CYP1A2, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.543E-03	6.000E-03	CYP1A2, CYP3A4
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	9.179E-05	4.590E-04	CA12, CA7
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	9.754E-06	6.828E-05	HSD17B2, CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	5.997E-07	6.997E-06	CYP1A2, CYP1A1, CYP1B1, CYP3A4

Showing 1 to 9 of 9 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	RAB9A;
C00-D49: Neoplasms	Melanoma	C43	TYR;
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	NR3C1;
C00-D49: Neoplasms	Cancer	C00-C96	HIF1A; NR3C1;
C00-D49: Neoplasms	Solid tumours	C00-D48	HIF1A;
C00-D49: Neoplasms	Multiple myeloma	C90	AHR;
E00-E89: Endocrine, nutritional and metabolic diseases	Xerophthalmia	E50.6-E50.7	NR3C1;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	NR3C1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NR3C1;

Showing 1 to 10 of 37 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Senecio mexicanus

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities