CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	TDP1; HSD17B10;
Hydrolase	ATP12A; ATP1A1;
Protein Kinase	PRKCA;
Metallo protease	MMP2; MMP9; MMP1;
Transcription Factor	NFKB1; TP53; STAT3;
SLC superfamily of solute carriers	SLCO4C1;
Unclassified	KLF5; LMNA; GMNN; PAX8; RAB9A; NPC1; MAPT;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Hydrolase	ATP12A	Potassium-transporting ATPase alpha chain 2	P54707	CHEMBL2933
Hydrolase	ATP1A1	Sodium/potassium-transporting ATPase alpha-1 chain	P05023	CHEMBL1807
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Metallo protease	MMP9	Matrix metalloproteinase 9	P14780	CHEMBL321
Metallo protease	MMP1	Matrix metalloproteinase-1	P03956	CHEMBL332
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Kinase	PRKCA	Protein kinase C alpha	P17252	CHEMBL299

Showing 1 to 10 of 21 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0038194; thyroid-stimulating hormone signaling pathway	1.238E-06	4.494E-03	PAX8, TSHR
BP	GO:0050896; response to stimulus	GO:0032870; cellular response to hormone stimulus	1.761E-06	5.479E-03	ATP1A1, NFKB1, NPC1, PAX8, STAT3, TSHR
MF	GO:0060089; molecular transducer activity	GO:0004996; thyroid-stimulating hormone receptor activity	1.238E-06	4.494E-03	PAX8, TSHR

Showing 1 to 3 of 3 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	1.576E-04	1.948E-03	PRKCA, MAPT, TP53, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	1.902E-04	2.156E-03	STAT3, PRKCA, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	2.985E-04	2.706E-03	PRKCA, TP53, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	1.300E-03	8.370E-03	ATP1A1, NFKB1, TSHR
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	4.690E-04	3.543E-03	LMNA, TP53, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04918	Thyroid hormone synthesis	1.016E-06	3.455E-05	PAX8, PRKCA, ATP1A1, TSHR
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	2.841E-04	2.706E-03	PRKCA, ATP1A1, TP53
09150 Organismal Systems	09151 Immune system	hsa04670	Leukocyte transendothelial migration	2.841E-04	2.706E-03	MMP2, PRKCA, MMP9
09150 Organismal Systems	09155 Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	1.212E-03	8.240E-03	PRKCA, ATP1A1
09150 Organismal Systems	09155 Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	8.351E-04	5.977E-03	PRKCA, ATP1A1

Showing 1 to 10 of 25 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	RAB9A;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ATP1A1;
C00-D49: Neoplasms	Pancreatic cancer	C25	MMP2;
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR;
C00-D49: Neoplasms	Ovarian cancer	C56	MMP2;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	MMP2;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	STAT3;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53;

Showing 1 to 10 of 45 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Digitalis purpurea

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Medicinal Functions:

Geographical Distribution:

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Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities