Plant ID: NPO4406
Plant Latin Name: Azadirachta indica
Taxonomy Genus: Azadirachta
Taxonomy Family: Meliaceae
NCBI TaxonomyDB:
124943
Plant-of-the-World-Online:
1213180-2
Bangladesh; Sudan; Guinea; Cambodia; Rwanda; Somalia; Nigeria; Cameroon; Burkina Faso; Ghana; Cuba; El Salvador; Togo; Thailand; Haiti; Mauritania; Netherlands; Pakistan; Gambia; Tanzania; Indonesia; Mauritius; Trinidad and Tobago; Guinea-Bissau; Kenya; Dominican Republic; Jamaica; Chad; Myanmar; India; Senegal; Uganda; Sri Lanka; Lebanon; Niger; United States
MIF; | |
GSK3B; | |
SMN1;SMN2; |
Cytochrome P450 Enzymes: |
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Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|
Enzyme_unclassified | MIF | Macrophage migration inhibitory factor | P14174 | CHEMBL2085 |
Methyl-lysine/arginine binding protein | SMN1;SMN2 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
Protein Kinase | GSK3B | Glycogen synthase kinase-3 beta | P49841 | CHEMBL262 |
GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|
CC | GO:0032991; macromolecular complex | GO:0030877; beta-catenin destruction complex | 1.708E-03 | 9.069E-01 | GSK3B |
MF | GO:0005488; binding | GO:0034452; dynactin binding | 1.708E-03 | 9.069E-01 | GSK3B |
MF | GO:0003824; catalytic activity | GO:0050321; tau-protein kinase activity | 2.018E-03 | 9.154E-01 | GSK3B |
CC | GO:0044464; cell part | GO:0043209; myelin sheath | 2.266E-02 | 1.000E+00 | MIF |
CC | GO:0044464; cell part | GO:0034774; secretory granule lumen | 4.903E-02 | 1.000E+00 | MIF |
MF | GO:0005488; binding | GO:0001085; RNA polymerase II transcription factor binding | 1.791E-02 | 1.000E+00 | GSK3B |
Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|---|
09100 Metabolism | 09105 Amino acid metabolism | hsa00360 | Phenylalanine metabolism | 2.548E-03 | 3.006E-02 | MIF |
09100 Metabolism | 09105 Amino acid metabolism | hsa00350 | Tyrosine metabolism | 5.241E-03 | 3.006E-02 | MIF |
09160 Human Diseases | 09161 Cancers | hsa05213 | Endometrial cancer | 7.780E-03 | 3.006E-02 | GSK3B |
09160 Human Diseases | 09161 Cancers | hsa05210 | Colorectal cancer | 9.272E-03 | 3.006E-02 | GSK3B |
09130 Environmental Information Processing | 09132 Signal transduction | hsa04340 | Hedgehog signaling pathway | 7.482E-03 | 3.006E-02 | GSK3B |
09160 Human Diseases | 09161 Cancers | hsa05217 | Basal cell carcinoma | 8.228E-03 | 3.006E-02 | GSK3B |
09150 Organismal Systems | 09152 Endocrine system | hsa04917 | Prolactin signaling pathway | 1.076E-02 | 3.006E-02 | GSK3B |
09150 Organismal Systems | 09151 Immune system | hsa04662 | B cell receptor signaling pathway | 1.091E-02 | 3.006E-02 | GSK3B |
09160 Human Diseases | 09161 Cancers | hsa05215 | Prostate cancer | 1.329E-02 | 3.006E-02 | GSK3B |
09130 Environmental Information Processing | 09132 Signal transduction | hsa04012 | ErbB signaling pathway | 1.299E-02 | 3.006E-02 | GSK3B |
ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
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