CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPBAR1;
Peptide receptor (family A GPCR)	TSHR;
Protein Phosphatase	PTPN1; PTPN2; ACP1; PTPRF;
Enzyme_unclassified	RECQL; TDP1; HSD11B1; AKR1B10; GFER; HSD17B10; ALDH1A1;
Lyase	CA1; CA12; CA9; CA13; CA7;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Cysteine protease	CASP1; CASP7;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cysteine protease	CASP1	Caspase-1	P29466	CHEMBL4801
Cysteine protease	CASP7	Caspase-7	P55210	CHEMBL3468
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	P28845	CHEMBL4235
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	5.529E-10	6.020E-06	CA1, CA12, CA13, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.583E-09	1.149E-05	CA1, CA12, CA13, CA7, CA9
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	4.066E-06	8.048E-03	GPBAR1, NR1H4
BP	GO:0008152; metabolic process	GO:0035335; peptidyl-tyrosine dephosphorylation	5.334E-06	9.679E-03	ACP1, PTPN1, PTPN2, PTPRF
BP	GO:0009987; cellular process	GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway	8.126E-06	1.180E-02	PTPN1, PTPN2
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	4.477E-12	9.748E-08	CA1, CA12, CA13, CA7, CA9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	2.656E-06	6.427E-03	CA1, CA12, CA13, CA7, CA9, NR1H4, PTPN1, RORC
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	4.066E-06	8.048E-03	GPBAR1, NR1H4
MF	GO:0003824; catalytic activity	GO:0001758; retinal dehydrogenase activity	2.838E-05	3.433E-02	AKR1B10, ALDH1A1
MF	GO:0003824; catalytic activity	GO:0004726; non-membrane spanning protein tyrosine phosphatase activity	3.781E-05	4.117E-02	ACP1, PTPN2

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	7.742E-12	3.019E-10	CA12, CA1, CA7, CA9, CA13
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2.011E-03	1.859E-02	HSD11B1, CYP1A2
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.518E-03	1.859E-02	CYP1A2, ALDH1A1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3.164E-03	1.859E-02	HSD11B1, CYP1A2
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	5.737E-03	2.486E-02	CYP1A2
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	8.165E-05	1.592E-03	PTPN1, ACP1, PTPRF
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	1.810E-03	1.859E-02	CASP7, CASP1
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	3.336E-03	1.859E-02	CASP7, CASP1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	3.973E-03	1.937E-02	HSD11B1, CYP1A2
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	6.910E-03	2.695E-02	PTPN1, PTPRF

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Cancer	C00-C96	CA9;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
C00-D49: Neoplasms	Breast cancer	C50	CA9;
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Aconitum zuccarini

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities