CMAUP Plant Collective Molecular Activities

Plant Name: Magnolia officinalis

Taxonomic Information:

Plant ID: NPO4368
Plant Latin Name: Magnolia officinalis
Taxonomy Genus: Magnolia
Taxonomy Family: Magnoliaceae

Plant External Links:

NCBI TaxonomyDB: 85864
Plant-of-the-World-Online: 554787-1

Used in Medicines:

Country/Region:

South Korea; China

Traditional Medicine System:

TCM; Kampo

Medicinal Functions:

Antibacterial; Antiseptic; Antispasmodic; Aphrodisiac; Appetizer; Digestive; Diuretic; Emmenagogue; Expectorant; Ophthalmic; Stomachic; Tonic

Geographical Distribution:

South Korea; China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	CNR1; CNR2;
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	GLA; ALOX15; PTPRCAP;
Transient receptor potential channel	TRPV1;
Protein Kinase	MAPK1;
Lyase	CA2; CA12; CA9; CA3; CA4;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD;
Nuclear hormone receptor subfamily 2 group B	RXRA;
Oxidoreductase	ALOX5; XDH;
Cysteine protease	CASP1; CASP7;
Toll-like and Il-1 receptors	TLR2;
Transcription Factor	HIF1A;
ATP-binding cassette	ABCB1;
Unclassified	LMNA; RAB9A; FABP3; FABP5; FABP2; FABP4; MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
ATP-binding cassette	ABCB1	P-glycoprotein 1	P08183	CHEMBL4302
Cysteine protease	CASP1	Caspase-1	P29466	CHEMBL4801
Cysteine protease	CASP7	Caspase-7	P55210	CHEMBL3468
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	GLA	Alpha-galactosidase A	P06280	CHEMBL2524
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	PTPRCAP	Protein tyrosine phosphatase receptor type C-associated protein	Q14761	CHEMBL4806
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA3	Carbonic anhydrase III	P07451	CHEMBL2885
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Nuclear hormone receptor subfamily 2 group B	RXRA	Retinoid X receptor alpha	P19793	CHEMBL2061
Oxidoreductase	XDH	Xanthine dehydrogenase	P47989	CHEMBL1929
Oxidoreductase	ALOX5	Arachidonate 5-lipoxygenase	P09917	CHEMBL215
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Small molecule receptor (family A GPCR)	CNR1	Cannabinoid CB1 receptor	P21554	CHEMBL218
Small molecule receptor (family A GPCR)	CNR2	Cannabinoid CB2 receptor	P34972	CHEMBL253
Toll-like and Il-1 receptors	TLR2	Toll-like receptor 2	O60603	CHEMBL4163
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Transient receptor potential channel	TRPV1	Vanilloid receptor	Q8NER1	CHEMBL4794
Unclassified	FABP2	Fatty acid binding protein intestinal	P12104	CHEMBL4879
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.253E-11	2.117E-07	CA12, CA2, CA3, CA4, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.762E-09	5.468E-06	CA12, CA2, CA3, CA4, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	7.886E-09	1.227E-05	CA12, CA2, CA3, CA4, CA9
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	6.705E-08	7.684E-05	FABP2, FABP3, FABP4, FABP5
BP	GO:0008152; metabolic process	GO:0051001; negative regulation of nitric-oxide synthase activity	1.304E-07	1.305E-04	CNR1, CNR2, GLA
BP	GO:0050896; response to stimulus	GO:0042493; response to drug	1.318E-07	1.305E-04	ABCB1, CA3, CA9, CASP1, CNR1, CNR2, FABP3, MAPK1, TLR2, TRPV1
BP	GO:0050896; response to stimulus	GO:0033993; response to lipid	1.304E-06	7.472E-04	CA2, CA9, CASP1, CNR1, CNR2, FABP3, PPARD, RXRA, TLR2
BP	GO:0050896; response to stimulus	GO:0050727; regulation of inflammatory response	2.168E-06	1.152E-03	CASP1, CNR1, CNR2, FABP4, PPARA, PPARD, TLR2
BP	GO:0002376; immune system process	GO:0001774; microglial cell activation	2.507E-06	1.300E-03	MAPT, TLR2, TRPV1
BP	GO:0050896; response to stimulus	GO:0001666; response to hypoxia	3.048E-06	1.537E-03	CASP1, HIF1A, LMNA, PPARA, PPARD, TLR2
BP	GO:0008152; metabolic process	GO:2000377; regulation of reactive oxygen species metabolic process	6.829E-06	3.035E-03	GLA, HIF1A, MAPT, TRPV1, XDH
MF	GO:0060089; molecular transducer activity	GO:0004949; cannabinoid receptor activity	7.471E-06	3.190E-03	CNR1, CNR2
BP	GO:0065007; biological regulation	GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process	8.698E-06	3.573E-03	CASP1, CASP7, MAPT, XDH
BP	GO:0032501; multicellular organismal process	GO:0001816; cytokine production	9.128E-06	3.681E-03	CASP1, FABP4, HIF1A, TLR2
BP	GO:0008152; metabolic process	GO:0046320; regulation of fatty acid oxidation	1.193E-05	4.331E-03	CNR1, FABP3, PPARA
BP	GO:0050896; response to stimulus	GO:0014070; response to organic cyclic compound	1.416E-05	4.973E-03	CA2, CA9, CASP1, CASP7, CNR1, MAPK1, TLR2, TRPV1
BP	GO:0065007; biological regulation	GO:0065009; regulation of molecular function	1.451E-05	5.015E-03	ABCB1, CASP1, CASP7, CNR1, CNR2, FABP4, GLA, HIF1A, MAPK1, MAPT, PPARA, RAB9A, TLR2, TRPV1, TSHR, XDH
BP	GO:0009987; cellular process	GO:0038171; cannabinoid signaling pathway	1.493E-05	5.019E-03	CNR1, CNR2
BP	GO:0008152; metabolic process	GO:0006691; leukotriene metabolic process	1.632E-05	5.212E-03	ALOX15, ALOX5, TLR2
BP	GO:0023052; signaling	GO:0032228; regulation of synaptic transmission, GABAergic	1.799E-05	5.596E-03	CA2, CNR1, CNR2
BP	GO:0009987; cellular process	GO:0071345; cellular response to cytokine stimulus	1.845E-05	5.657E-03	ALOX15, CASP1, FABP4, HIF1A, MAPK1, TRPV1
MF	GO:0005488; binding	GO:0008270; zinc ion binding	3.168E-05	8.515E-03	CA12, CA2, CA3, CA4, CA9, PPARA, PPARD, RXRA
BP	GO:0007610; behavior	GO:0007611; learning or memory	3.352E-05	8.901E-03	CNR1, HIF1A, MAPK1, MAPT, TLR2
BP	GO:0008152; metabolic process	GO:2001300; lipoxin metabolic process	3.724E-05	9.770E-03	ALOX15, ALOX5
MF	GO:0140110; transcription regulator activity	GO:0004879; nuclear receptor activity	6.559E-05	1.587E-02	PPARA, PPARD, RXRA
CC	GO:0044464; cell part	GO:0032838; plasma membrane bounded cell projection cytoplasm	1.673E-04	2.961E-02	HIF1A, MAPK1, MAPT
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	2.137E-04	3.664E-02	CA2, CA4, CA9, TSHR

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	1.048E-11	1.446E-09	FABP2, FABP3, RXRA, FABP4, FABP5, PPARA, PPARD
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	3.894E-11	2.687E-09	CA12, CA3, CA2, CA4, CA9
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	4.267E-06	1.963E-04	ABCB1, RXRA, CA2, CYP3A4
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	8.376E-05	2.890E-03	CASP7, CASP1, TLR2
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	2.111E-04	5.827E-03	CASP7, CASP1, MAPK1
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	6.855E-04	1.058E-02	ALOX5, ALOX15, MAPK1
09160 Human Diseases	09167 Infectious diseases	hsa05145	Toxoplasmosis	7.977E-04	1.058E-02	ALOX5, MAPK1, TLR2
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	7.977E-04	1.058E-02	RXRA, MAPK1, HIF1A
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	8.438E-04	1.058E-02	CNR2, CNR1, TRPV1, TSHR
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	9.197E-04	1.058E-02	ALOX15, CYP3A4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
NA: NA	Esophagus sensitivity	NA	TRPV1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Musculoskeletal pain	R52, G89	TRPV1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Chronic pathological pain	R52, G89	TRPV1;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Immune disorder	D80-D89	CNR2;
C00-D49: Neoplasms	Cutaneous T-cell lymphoma	C84.0, C84.1	RXRA;
K00-K95: Diseases of the digestive system	Gastroesophageal reflux disease	K21	TRPV1;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	CNR2; TRPV1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cough	R05	TRPV1;
N00-N99: Diseases of the genitourinary system	Urinary incontinence	N39.3, N39.4, R32	TRPV1;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	CNR2;
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	CNR2;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CNR2; TRPV1;
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Acute or chronic pain	R52, G89	TRPV1;
G00-G99: Diseases of the nervous system G00-G99	Acute migraine	G43	TRPV1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoporosis	M80-M81, Z79.890	CNR2;
C00-D49: Neoplasms	Overactive bladder disorder	C67, N32.81	TRPV1;
C00-D49: Neoplasms	Solid tumours	C00-D48	MAPK1;
A00-B99: Certain infectious and parasitic diseases	Postherpetic neuralgia	B02.2, G44.847, G53.0	TRPV1;
C00-D49: Neoplasms	Cancer	C00-C96	MAPK1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	CNR2;
J00-J99: Diseases of the respiratory system	Asthma	J45	TRPV1;
L00-L99: Diseases of the skin and subcutaneous tissue	Atopic dermatitis	L00-L99	CNR2; TRPV1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	TRPV1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases