Plant Name: Inula hupehensis
Taxonomic Information:
Plant ID: NPO4280
Plant Latin Name: Inula hupehensis
Taxonomy Genus: Inula
Taxonomy Family: Asteraceae
Plant External Links:
NCBI TaxonomyDB:
1805964
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| RXRA; | |
| PTGS2; | |
| MDM2; | |
| XBP1; HTT; RAB9A; NPC1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Nuclear hormone receptor subfamily 2 group B | RXRA | Retinoid X receptor alpha | P19793 | CHEMBL2061 |
| Oxidoreductase | PTGS2 | Cyclooxygenase-2 | P35354 | CHEMBL230 |
| Transferase | MDM2 | p53-binding protein Mdm-2 | Q00987 | CHEMBL5023 |
| Unclassified | XBP1 | X-box-binding protein 1 | P17861 | CHEMBL1741176 |
| Unclassified | HTT | Huntingtin | P42858 | CHEMBL5514 |
| Unclassified | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
| Unclassified | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0065007; biological regulation | GO:0031648; protein destabilization | 3.325E-07 | 3.427E-03 | HTT, MDM2, XBP1 |
| BP | GO:0009987; cellular process | GO:0031670; cellular response to nutrient | 3.835E-07 | 3.427E-03 | MDM2, PTGS2, XBP1 |
| BP | GO:0050896; response to stimulus | GO:0033993; response to lipid | 1.420E-06 | 7.729E-03 | MDM2, NPC1, PTGS2, RXRA, XBP1 |
| BP | GO:0050896; response to stimulus | GO:0009750; response to fructose | 3.149E-06 | 1.371E-02 | PTGS2, XBP1 |
| BP | GO:0009987; cellular process | GO:2001243; negative regulation of intrinsic apoptotic signaling pathway | 3.977E-06 | 1.443E-02 | MDM2, PTGS2, XBP1 |
| BP | GO:0009987; cellular process | GO:0060548; negative regulation of cell death | 5.620E-06 | 1.446E-02 | HTT, MDM2, NPC1, PTGS2, XBP1 |
| BP | GO:0051179; localization | GO:0051050; positive regulation of transport | 5.977E-06 | 1.446E-02 | HTT, MDM2, PTGS2, RAB9A, XBP1 |
| CC | GO:0044464; cell part | GO:0005783; endoplasmic reticulum | 1.762E-04 | 1.023E-01 | HTT, NPC1, PTGS2, XBP1 |
| CC | GO:0044464; cell part | GO:0005773; vacuole | 1.811E-04 | 1.023E-01 | HTT, NPC1, RAB9A |
| MF | GO:0005488; binding | GO:0002039; p53 binding | 2.687E-04 | 1.181E-01 | HTT, MDM2 |
| MF | GO:0003824; catalytic activity | GO:0004666; prostaglandin-endoperoxide synthase activity | 7.247E-04 | 1.503E-01 | PTGS2 |
| CC | GO:0044464; cell part | GO:0005770; late endosome | 9.951E-04 | 1.643E-01 | HTT, RAB9A |
| MF | GO:0005488; binding | GO:0008134; transcription factor binding | 9.052E-04 | 1.643E-01 | HTT, RXRA, XBP1 |
| MF | GO:0003824; catalytic activity | GO:0050473; arachidonate 15-lipoxygenase activity | 1.087E-03 | 1.643E-01 | PTGS2 |
| MF | GO:0005488; binding | GO:0050692; DBD domain binding | 1.087E-03 | 1.643E-01 | RXRA |
| MF | GO:0005215; transporter activity | GO:0005319; lipid transporter activity | 1.131E-03 | 1.687E-01 | HTT, NPC1 |
| CC | GO:0016020; membrane | GO:0005789; endoplasmic reticulum membrane | 3.273E-03 | 2.855E-01 | PTGS2, RAB9A, XBP1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09160 Human Diseases | 09161 Cancers | hsa05200 | Pathways in cancer | 2.560E-04 | 8.137E-03 | RXRA, MDM2, PTGS2 |
| 09160 Human Diseases | 09161 Cancers | hsa05222 | Small cell lung cancer | 3.785E-04 | 8.137E-03 | RXRA, PTGS2 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04919 | Thyroid hormone signaling pathway | 7.110E-04 | 1.019E-02 | RXRA, MDM2 |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04932 | Non-alcoholic fatty liver disease (NAFLD) | 1.160E-03 | 1.247E-02 | XBP1, RXRA |
| 09160 Human Diseases | 09161 Cancers | hsa05202 | Transcriptional misregulation in cancer | 1.642E-03 | 1.412E-02 | RXRA, MDM2 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04151 | PI3K-Akt signaling pathway | 5.752E-03 | 3.533E-02 | RXRA, MDM2 |
| 09160 Human Diseases | 09161 Cancers | hsa05206 | MicroRNAs in cancer | 4.394E-03 | 3.149E-02 | MDM2, PTGS2 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04913 | Ovarian steroidogenesis | 1.737E-02 | 4.940E-02 | PTGS2 |
| 09160 Human Diseases | 09161 Cancers | hsa05216 | Thyroid cancer | 1.011E-02 | 4.940E-02 | RXRA |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 2.459E-02 | 4.940E-02 | RXRA |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Cutaneous T-cell lymphoma | C84.0, C84.1 | RXRA; |
| C00-D49: Neoplasms | Cancer | C00-C96 | MDM2; |
| C00-D49: Neoplasms | Prostate cancer | C61 | MDM2; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | MDM2; |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | MDM2; |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | MDM2; |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | MDM2; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
