CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Hydrolase	ACHE;
Protein Kinase	FLT3; CDK8; CSNK2A1;
Lyase	CA2; CA12; CA14; CA7; CA4;
Nuclear hormone receptor subfamily 3 group A	ESR2;
Enzyme_unclassified	HSD17B1; HSD17B10; NOX4;
Metallo protease	MMP9; MMP1; MMP12; MMP2;
Transcription Factor	HIF1A; NFKB1;
Unclassified	FABP4; THPO;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP19A1; CYP2C19; CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Enzyme_unclassified	HSD17B1	Estradiol 17-beta-dehydrogenase 1	P14061	CHEMBL3181
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205

Showing 1 to 10 of 28 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	8.548E-10	4.653E-06	CYP1A1, CYP1A2, CYP1B1, CYP2C19
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	5.530E-09	2.408E-05	CA12, CA14, CA2, CA4, CA7
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	2.409E-08	7.493E-05	CYP1A1, CYP1A2, CYP1B1, CYP2C19
BP	Unclassified;	GO:0044259; multicellular organismal macromolecule metabolic process	1.698E-07	2.641E-04	HIF1A, MMP1, MMP12, MMP2, MMP9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.334E-07	3.388E-04	CA12, CA2, CA4, CA7
BP	Unclassified;	GO:0044236; multicellular organism metabolic process	4.839E-07	6.198E-04	HIF1A, MMP1, MMP12, MMP2, MMP9
BP	GO:0008152; metabolic process	GO:0030574; collagen catabolic process	2.603E-06	2.267E-03	MMP1, MMP12, MMP2, MMP9
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	5.281E-06	3.455E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0009987; cellular process	GO:0022617; extracellular matrix disassembly	5.694E-06	3.455E-03	MMP1, MMP12, MMP2, MMP9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	6.523E-06	3.633E-03	CA2, CA7

Showing 1 to 10 of 19 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.724E-11	2.670E-09	CA12, CA2, CA4, CA7, CA14
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.936E-08	9.487E-07	HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP19A1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	2.612E-05	3.942E-04	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.592E-04	1.951E-03	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	8.044E-04	7.167E-03	CYP1A2, CYP2C19
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	7.838E-07	2.560E-05	HSD17B1, CYP1A1, CYP1B1, CYP19A1
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	3.915E-04	4.263E-03	MMP2, MMP9, ESR2
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	5.040E-04	4.939E-03	CA2, CA4
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	1.900E-05	3.725E-04	FLT3, MMP1, MMP2, HIF1A, MMP9, NFKB1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	5.765E-06	1.412E-04	CYP1A2, CYP1A1, CYP1B1, CYP2C19

Showing 1 to 10 of 11 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
C00-D49: Neoplasms	Lung cancer	C33-C34	MMP2;
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A;
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
C00-D49: Neoplasms	Cancer	C00-C96	CSNK2A1; NFKB1; FLT3; ACHE; HIF1A; MMP9; MMP2;
C00-D49: Neoplasms	CLL	NA	FLT3;

Showing 1 to 10 of 77 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Phlomoides rotata

Taxonomic Information:

Plant External Links:

Used in Medicines:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities