Plant Name: Gynochthodes umbellata
Taxonomic Information:
Plant ID: NPO4192
Plant Latin Name: Gynochthodes umbellata
Taxonomy Genus: Gynochthodes
Taxonomy Family: Rubiaceae
Plant External Links:
NCBI TaxonomyDB:
268745
Plant-of-the-World-Online:
77117618-1
Used in Medicines:
Unknown.
Geographical Distribution:
Australia; Bangladesh; Philippines; Indonesia; India; Cambodia; Vietnam; China; Papua New Guinea; Thailand; Sri Lanka; Japan; Taiwan
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Miscellaneous ion channel | BCL2 | Apoptosis regulator Bcl-2 | P10415 | CHEMBL4860 |
| Unclassified | SERPINA6 | Corticosteroid binding globulin | P08185 | CHEMBL2421 |
| Unclassified | MCL1 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Q07820 | CHEMBL4361 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0005488; binding | GO:0051434; BH3 domain binding | 1.608E-07 | 3.501E-03 | BCL2, MCL1 |
| BP | GO:0009987; cellular process | GO:2000811; negative regulation of anoikis | 1.929E-06 | 1.050E-02 | BCL2, MCL1 |
| BP | GO:0009987; cellular process | GO:2001240; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand | 9.012E-06 | 2.180E-02 | BCL2, MCL1 |
| BP | GO:0009987; cellular process | GO:2001244; positive regulation of intrinsic apoptotic signaling pathway | 2.472E-05 | 4.893E-02 | BCL2, MCL1 |
| BP | GO:0009987; cellular process | GO:0008637; apoptotic mitochondrial changes | 2.841E-05 | 5.155E-02 | BCL2, MCL1 |
| BP | GO:0009987; cellular process | GO:0008630; intrinsic apoptotic signaling pathway in response to DNA damage | 3.655E-05 | 6.122E-02 | BCL2, MCL1 |
| CC | GO:0032991; macromolecular complex | GO:0097136; Bcl-2 family protein complex | 9.316E-04 | 4.140E-01 | MCL1 |
| MF | GO:0005215; transporter activity | GO:0015267; channel activity | 1.781E-03 | 5.691E-01 | BCL2, MCL1 |
| MF | GO:0005488; binding | GO:0046982; protein heterodimerization activity | 1.948E-03 | 5.938E-01 | BCL2, MCL1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 1.453E-04 | 2.036E-03 | BCL2, MCL1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04630 | Jak-STAT signaling pathway | 1.851E-04 | 2.036E-03 | BCL2, MCL1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04151 | PI3K-Akt signaling pathway | 8.598E-04 | 4.729E-03 | BCL2, MCL1 |
| 09160 Human Diseases | 09161 Cancers | hsa05206 | MicroRNAs in cancer | 6.529E-04 | 4.729E-03 | BCL2, MCL1 |
| 09160 Human Diseases | 09161 Cancers | hsa05222 | Small cell lung cancer | 1.285E-02 | 2.624E-02 | BCL2 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04725 | Cholinergic synapse | 1.656E-02 | 2.624E-02 | BCL2 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04064 | NF-kappa B signaling pathway | 1.389E-02 | 2.624E-02 | BCL2 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04066 | HIF-1 signaling pathway | 1.537E-02 | 2.624E-02 | BCL2 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05145 | Toxoplasmosis | 1.760E-02 | 2.624E-02 | BCL2 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04722 | Neurotrophin signaling pathway | 1.789E-02 | 2.624E-02 | BCL2 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
