CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Oxidoreductase	PTGS2; ALOX5;
Enzyme_unclassified	IDO1;
Unclassified	RAB9A; LMNA; NPC1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	IDO1	Indoleamine 2,3-dioxygenase	P14902	CHEMBL4685
Oxidoreductase	PTGS2	Cyclooxygenase-2	P35354	CHEMBL230
Oxidoreductase	ALOX5	Arachidonate 5-lipoxygenase	P09917	CHEMBL215
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277

Showing 1 to 6 of 6 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0032501; multicellular organismal process	GO:0002532; production of molecular mediator involved in inflammatory response	2.250E-06	1.225E-02	ALOX5, IDO1
BP	GO:0008152; metabolic process	GO:0032787; monocarboxylic acid metabolic process	5.385E-06	2.345E-02	ALOX5, IDO1, NPC1, PTGS2
BP	GO:0008152; metabolic process	GO:0019372; lipoxygenase pathway	9.631E-06	3.292E-02	ALOX5, PTGS2
BP	GO:0008152; metabolic process	GO:0046456; icosanoid biosynthetic process	5.329E-05	9.166E-02	ALOX5, PTGS2
BP	GO:0009987; cellular process	GO:0060548; negative regulation of cell death	8.188E-05	1.180E-01	IDO1, LMNA, NPC1, PTGS2
CC	GO:0016020; membrane	GO:0031090; organelle membrane	2.903E-04	2.416E-01	ALOX5, LMNA, NPC1, PTGS2, RAB9A
CC	GO:0044464; cell part	GO:0032421; stereocilium bundle	1.552E-03	4.966E-01	IDO1
CC	GO:0044464; cell part	GO:0005641; nuclear envelope lumen	2.483E-03	5.691E-01	ALOX5
CC	GO:0044464; cell part	GO:0005764; lysosome	2.896E-03	5.875E-01	NPC1, RAB9A
MF	GO:0003824; catalytic activity	GO:0004666; prostaglandin-endoperoxide synthase activity	6.212E-04	3.411E-01	PTGS2

Showing 1 to 10 of 12 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
No data available in table

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	ALOX5;
A00-B99: Certain infectious and parasitic diseases	Lymphatic filariasis	B74	ALOX5;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	PTGS2;
C00-D49: Neoplasms	Pancreatic cancer	C25	PTGS2;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	PTGS2; ALOX5;
C00-D49: Neoplasms	Cancer	C00-C96	PTGS2;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PTGS2;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	PTGS2; ALOX5;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	PTGS2;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	PTGS2;

Showing 1 to 10 of 37 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Phaius mishmensis

Taxonomic Information:

Plant External Links:

Used in Medicines:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities