CMAUP Plant Collective Molecular Activities

Plant Name: Betula platyphylla

Taxonomic Information:

Plant ID: NPO4138
Plant Latin Name: Betula platyphylla
Taxonomy Genus: Betula
Taxonomy Family: Betulaceae

Plant External Links:

NCBI TaxonomyDB: 78630
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

South Korea; China

Traditional Medicine System:

TCM

Medicinal Functions:

Antifungal; Antiinflammatory; Antiseborrheic; Cancer; Tonic

Geographical Distribution:

South Korea; China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	ALPL;
Lyase	CA2; CA12; CA7;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Transcription Factor	NFKB1;
SLC superfamily of solute carriers	SLC5A2; SLC5A1; SLC5A4;
Unclassified	FABP4;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
SLC superfamily of solute carriers	SLC5A2	Sodium/glucose cotransporter 2	P31639	CHEMBL3884
SLC superfamily of solute carriers	SLC5A1	Sodium/glucose cotransporter 1	P13866	CHEMBL4979
SLC superfamily of solute carriers	SLC5A4	Low affinity sodium-glucose cotransporter	Q9NY91	CHEMBL1770047
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005215; transporter activity	GO:0005412; glucose:sodium symporter activity	1.997E-09	4.348E-05	SLC5A1, SLC5A2, SLC5A4
BP	Unclassified;	GO:0035428; hexose transmembrane transport	1.531E-07	4.762E-04	SLC5A1, SLC5A2, SLC5A4
BP	GO:0051179; localization	GO:1904659; glucose transmembrane transport	1.531E-07	4.762E-04	SLC5A1, SLC5A2, SLC5A4
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	4.532E-08	4.762E-04	CA12, CA2, CA7
BP	GO:0051179; localization	GO:0006811; ion transport	6.366E-07	1.212E-03	CA12, CA2, CA7, NR1H4, SLC5A1, SLC5A2, SLC5A4
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	7.070E-07	1.212E-03	CA12, CA2, CA7
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	7.235E-07	1.212E-03	CA2, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.309E-06	1.900E-03	CA12, CA2, CA7
BP	Unclassified;	GO:0015758; glucose transport	1.499E-06	1.920E-03	SLC5A1, SLC5A2, SLC5A4
BP	GO:0051179; localization	GO:2001225; regulation of chloride transport	1.083E-05	9.827E-03	CA2, CA7

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	6.098E-08	3.903E-06	CA12, CA2, CA7
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	5.054E-06	1.617E-04	CA2, NR1H4, SLC5A1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;
A00-B99: Certain infectious and parasitic diseases	Anthelmintic	B89	ALPL;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	SLC5A4; SLC5A1; SLC5A2;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1;
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Genetic disease	Q00-Q99	ALPL;
NA: NA	Edema	NA	CA2;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 1 diabetes	E10	SLC5A2;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1; SLC5A4; SLC5A1; SLC5A2;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 1/2 diabetes	E08-E13	SLC5A4;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	SLC5A2;
C00-D49: Neoplasms	Colon cancer	C50	ALPL;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases