CMAUP Plant Collective Molecular Activities

Plant Name: Homalomena occulta

Taxonomic Information:

Plant ID: NPO4044
Plant Latin Name: Homalomena occulta
Taxonomy Genus: Homalomena
Taxonomy Family: Araceae

Plant External Links:

NCBI TaxonomyDB: 714477
Plant-of-the-World-Online: 87255-1

Used in Medicines:

Country/Region:

Indonesia

Traditional Medicine System:

Geographical Distribution:

Thailand; Indonesia; China; Vietnam; Laos

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Hydrolase	GAA;
Transient receptor potential channel	TRPA1;
Lyase	CA2; CA1; CA12; CA9; CA7; CA14; CA5B; CA5A; CA4; CA6;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD;
Oxidoreductase	PTGS1;
Enzyme_unclassified	ALOX15;
Toll-like and Il-1 receptors	TLR2;
Unclassified	HTT; FABP3; FABP5; FABP2; FABP4; MAPT;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Oxidoreductase	PTGS1	Cyclooxygenase-1	P23219	CHEMBL221
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Toll-like and Il-1 receptors	TLR2	Toll-like receptor 2	O60603	CHEMBL4163
Transient receptor potential channel	TRPA1	Transient receptor potential cation channel subfamily A member 1	O75762	CHEMBL6007
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674
Unclassified	FABP2	Fatty acid binding protein intestinal	P12104	CHEMBL4879
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0005504; fatty acid binding	2.324E-10	3.615E-07	FABP2, FABP3, FABP4, FABP5, PPARD
MF	GO:0005488; binding	GO:0008270; zinc ion binding	2.972E-09	4.315E-06	CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, PPARA, PPARD
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	3.200E-08	3.667E-05	FABP2, FABP3, FABP4, FABP5
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	7.994E-27	1.741E-22	CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	5.222E-06	4.104E-03	CA2, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	6.462E-21	7.036E-17	CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.796E-19	1.522E-15	CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	2.605E-05	1.661E-02	CA1, CA2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	3.650E-26	1.825E-24	CA12, CA1, CA5B, CA2, CA5A, CA4, CA7, CA6, CA9, CA14
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	2.944E-10	7.359E-09	FABP2, FABP3, FABP4, FABP5, PPARA, PPARD
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	5.165E-05	8.608E-04	FABP4, TSHR, PTGS1
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4.043E-04	5.054E-03	CA2, CA4
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	2.929E-03	2.929E-02	ALOX15, PTGS1
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	9.253E-03	7.711E-02	ALOX15, PTGS1
09120 Genetic Information Processing	09122 Translation	hsa03013	RNA transport	2.087E-02	1.491E-01	SMN2, SMN1
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	2.737E-02	1.711E-01	PPARA, TSHR
09150 Organismal Systems	09155 Excretory system	hsa04966	Collecting duct acid secretion	3.454E-02	1.741E-01	CA2
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	3.705E-02	1.741E-01	ALOX15

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;
NA: NA	Edema	NA	CA2;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases