CMAUP Plant Collective Molecular Activities

Plant Name: Gentiana lutea

Taxonomic Information:

Plant ID: NPO403
Plant Latin Name: Gentiana lutea
Taxonomy Genus: Gentiana
Taxonomy Family: Gentianaceae

Plant External Links:

NCBI TaxonomyDB: 38851
Plant-of-the-World-Online: 368453-1

Used in Medicines:

Country/Region:

Romania; Albania; India; Switzerland; Spain; Bulgaria

Traditional Medicine System:

Medicinal Functions:

Anthelmintic; Antiinflammatory; Antiseptic; Appetizer; Bitter; Cholagogue; Emmenagogue; Febrifuge; Refrigerant; Stomachic; Tonic

Geographical Distribution:

Turkey; Ukraine; Romania; Albania; Italy; Portugal; India; France; Austria; Germany; Greece; Switzerland; Spain; Bulgaria

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Oxidoreductase	MAOA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Oxidoreductase	MAOA	Monoamine oxidase A	P21397	CHEMBL1951

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	3.106E-04	3.074E-01	NR1H4
MF	GO:0003824; catalytic activity	GO:0008131; primary amine oxidase activity	6.212E-04	4.509E-01	MAOA
MF	GO:0060089; molecular transducer activity	GO:0004887; thyroid hormone receptor activity	7.247E-04	4.782E-01	NR1H4
MF	GO:0005488; binding	GO:0046965; retinoid X receptor binding	1.553E-03	6.501E-01	NR1H4
MF	GO:0005488; binding	GO:0016922; ligand-dependent nuclear receptor binding	2.173E-03	7.280E-01	NR1H4

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09105 Amino acid metabolism	hsa00340	Histidine metabolism	2.399E-03	9.923E-03	MAOA
09100 Metabolism	09105 Amino acid metabolism	hsa00360	Phenylalanine metabolism	1.699E-03	9.923E-03	MAOA
09100 Metabolism	09105 Amino acid metabolism	hsa00350	Tyrosine metabolism	3.497E-03	9.923E-03	MAOA
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	3.996E-03	9.923E-03	MAOA
09100 Metabolism	09105 Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	3.996E-03	9.923E-03	MAOA
09160 Human Diseases	09164 Substance dependence	hsa05030	Cocaine addiction	4.894E-03	9.923E-03	MAOA
09160 Human Diseases	09164 Substance dependence	hsa05031	Amphetamine addiction	6.689E-03	9.923E-03	MAOA
09100 Metabolism	09105 Amino acid metabolism	hsa00330	Arginine and proline metabolism	4.994E-03	9.923E-03	MAOA
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	6.888E-03	9.923E-03	MAOA
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	7.088E-03	9.923E-03	NR1H4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases