CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Hydrolase	ACHE; BCHE;
Enzyme_unclassified	RECQL; BLM; HSD17B10; ALOX15;
Protein Kinase	MAPK1; PIM1; CSNK2A1;
Lyase	CA2; CA1; CA12; CA9; CA14; CA3; CA7; CA5A; CA6;
Nuclear hormone receptor subfamily 3 group A	ESR1; ESR2;
Serine protease	ELANE;
Transcription Factor	HIF1A;
Unclassified	LMNA; MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C9; CYP3A4;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Hydrolase	BCHE	Butyrylcholinesterase	P06276	CHEMBL1914
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	5.640E-06	6.608E-03	CA2, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	3.134E-18	3.412E-14	CA1, CA12, CA14, CA2, CA3, CA5A, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.366E-16	7.435E-13	CA1, CA12, CA2, CA3, CA5A, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	2.813E-05	1.764E-02	CYP2C9, CYP3A4
CC	GO:0044464; cell part	GO:0032838; plasma membrane bounded cell projection cytoplasm	1.099E-04	4.274E-02	HIF1A, MAPK1, MAPT
MF	GO:0005488; binding	GO:0008270; zinc ion binding	4.825E-09	1.051E-05	BLM, CA1, CA12, CA2, CA3, CA5A, CA6, CA7, CA9, ESR1, ESR2
MF	GO:0060089; molecular transducer activity	GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding	1.882E-06	2.561E-03	ESR1, ESR2
MF	GO:0003824; catalytic activity	GO:0003990; acetylcholinesterase activity	1.882E-06	2.561E-03	ACHE, BCHE
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.267E-23	4.936E-19	CA1, CA12, CA14, CA2, CA3, CA5A, CA6, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	1.127E-05	1.023E-02	CYP2C9, CYP3A4

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	8.038E-23	9.886E-21	CA12, CA1, CA3, CA2, CA5A, CA7, CA6, CA9, CA14
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	7.832E-06	4.816E-04	CYP2C9, ALOX15, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	3.157E-03	3.051E-02	CYP2C9, ALOX15
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	1.230E-04	5.042E-03	MAPK1, ESR1, ESR2
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	3.157E-04	9.707E-03	MAPK1, ESR1, ESR2
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	4.534E-04	1.083E-02	CYP2C9, ALOX15, MAPK1
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	5.281E-04	1.083E-02	MAPK1, ESR1, HIF1A
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	4.118E-03	3.051E-02	CA2, CYP3A4
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	1.468E-03	2.580E-02	MAPK1, MAPT, HSD17B10
09160 Human Diseases	09161 Cancers	hsa05211	Renal cell carcinoma	3.569E-03	3.051E-02	MAPK1, HIF1A

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
C00-D49: Neoplasms	Cancer	C00-C96	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Frangula purshiana

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Geographical Distribution:

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Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities