CMAUP Plant Collective Molecular Activities

Plant Name: Frangula purshiana

Taxonomic Information:

Plant ID: NPO3980
Plant Latin Name: Frangula purshiana
Taxonomy Genus: Frangula
Taxonomy Family: Rhamnaceae

Plant External Links:

NCBI TaxonomyDB: 55262
Plant-of-the-World-Online: 30426867-2

Used in Medicines:

Country/Region:

United States; Canada; India

Traditional Medicine System:

Homeopathy

Geographical Distribution:

Canada; United States; India; Mexico

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Hydrolase	ACHE; BCHE;
Enzyme_unclassified	RECQL; BLM; HSD17B10; ALOX15;
Protein Kinase	MAPK1; PIM1; CSNK2A1;
Lyase	CA2; CA1; CA12; CA9; CA14; CA3; CA7; CA5A; CA6;
Nuclear hormone receptor subfamily 3 group A	ESR1; ESR2;
Serine protease	ELANE;
Transcription Factor	HIF1A;
Unclassified	LMNA; MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C9; CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Hydrolase	BCHE	Butyrylcholinesterase	P06276	CHEMBL1914
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA3	Carbonic anhydrase III	P07451	CHEMBL2885
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Nuclear hormone receptor subfamily 3 group A	ESR1	Estrogen receptor alpha	P03372	CHEMBL206
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	CSNK2A1	Casein kinase II alpha	P68400	CHEMBL3629
Serine protease	ELANE	Leukocyte elastase	P08246	CHEMBL248
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	4.825E-09	1.051E-05	BLM, CA1, CA12, CA2, CA3, CA5A, CA6, CA7, CA9, ESR1, ESR2
MF	GO:0060089; molecular transducer activity	GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding	1.882E-06	2.561E-03	ESR1, ESR2
MF	GO:0003824; catalytic activity	GO:0003990; acetylcholinesterase activity	1.882E-06	2.561E-03	ACHE, BCHE
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	5.640E-06	6.608E-03	CA2, CA7
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.267E-23	4.936E-19	CA1, CA12, CA14, CA2, CA3, CA5A, CA6, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	3.134E-18	3.412E-14	CA1, CA12, CA14, CA2, CA3, CA5A, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.366E-16	7.435E-13	CA1, CA12, CA2, CA3, CA5A, CA6, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	1.127E-05	1.023E-02	CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	2.813E-05	1.764E-02	CYP2C9, CYP3A4
CC	GO:0044464; cell part	GO:0032838; plasma membrane bounded cell projection cytoplasm	1.099E-04	4.274E-02	HIF1A, MAPK1, MAPT

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	8.038E-23	9.886E-21	CA12, CA1, CA3, CA2, CA5A, CA7, CA6, CA9, CA14
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	7.832E-06	4.816E-04	CYP2C9, ALOX15, CYP3A4
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	1.230E-04	5.042E-03	MAPK1, ESR1, ESR2
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	3.157E-04	9.707E-03	MAPK1, ESR1, ESR2
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	4.534E-04	1.083E-02	CYP2C9, ALOX15, MAPK1
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	5.281E-04	1.083E-02	MAPK1, ESR1, HIF1A
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	1.468E-03	2.580E-02	MAPK1, MAPT, HSD17B10
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	3.157E-03	3.051E-02	CYP2C9, ALOX15
09160 Human Diseases	09161 Cancers	hsa05211	Renal cell carcinoma	3.569E-03	3.051E-02	MAPK1, HIF1A
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	4.118E-03	3.051E-02	CA2, CYP3A4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
C00-D49: Neoplasms	Cancer	C00-C96	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
NA: NA	Upper abdominal bloating	NA	ACHE;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases