CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	NPSR1;
Protein Kinase	IGF1R; FLT3; AURKB; AXL; KDR; CDK1; MAP2K1; PIM1; MET;
Enzyme_unclassified	ALOX12; NOX4; HSD17B10; POLB;
Oxidoreductase	PTGS2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP2C19;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Oxidoreductase	PTGS2	Cyclooxygenase-2	P35354	CHEMBL230
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Kinase	IGF1R	Insulin-like growth factor I receptor	P08069	CHEMBL1957
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974

Showing 1 to 10 of 17 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0018108; peptidyl-tyrosine phosphorylation	8.333E-09	1.650E-05	AXL, FLT3, IGF1R, KDR, MAP2K1, MET
BP	GO:0009987; cellular process	GO:0043066; negative regulation of apoptotic process	2.473E-07	2.071E-04	ALOX12, AURKB, AXL, CDK1, IGF1R, KDR, PIM1, PTGS2
BP	GO:0008152; metabolic process	GO:0046777; protein autophosphorylation	5.729E-07	4.455E-04	AURKB, FLT3, IGF1R, KDR, PIM1
BP	GO:0032502; developmental process	GO:0045766; positive regulation of angiogenesis	8.530E-06	2.575E-03	ALOX12, CYP1B1, KDR, PTGS2
BP	GO:0009987; cellular process	GO:0070301; cellular response to hydrogen peroxide	1.975E-05	4.886E-03	AXL, CDK1, CYP1B1
BP	GO:0009987; cellular process	GO:0007569; cell aging	2.391E-05	5.481E-03	CDK1, MAP2K1, NOX4
BP	GO:0008152; metabolic process	GO:0051054; positive regulation of DNA metabolic process	3.057E-05	6.590E-03	AURKB, CDK1, IGF1R, NOX4
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	3.267E-05	6.971E-03	CYP1B1, CYP2C19
BP	GO:0032502; developmental process	GO:0031100; animal organ regeneration	3.825E-05	7.785E-03	AXL, CDK1, FLT3
CC	GO:0043226; organelle	GO:0005876; spindle microtubule	1.291E-05	3.604E-03	AURKB, CDK1, POLB

Showing 1 to 10 of 14 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	1.870E-05	2.362E-04	ALOX12, CYP2C19, PTGS2
09130 Environmental Information Processing	09132 Signal transduction	hsa04370	VEGF signaling pathway	1.781E-05	2.362E-04	MAP2K1, KDR, PTGS2
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	2.573E-05	2.362E-04	MAP2K1, KDR, MET, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	3.425E-05	2.661E-04	MAP2K1, KDR, MET, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	1.658E-04	9.850E-04	MAP2K1, KDR, MET, IGF1R
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	1.363E-03	6.204E-03	FLT3, KDR, MET
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04510	Focal adhesion	2.169E-05	2.362E-04	MAP2K1, KDR, MET, IGF1R
09140 Cellular Processes	09143 Cell growth and death	hsa04114	Oocyte meiosis	1.449E-04	9.149E-04	MAP2K1, CDK1, IGF1R
09140 Cellular Processes	09141 Transport and catabolism	hsa04144	Endocytosis	1.276E-03	6.204E-03	KDR, MET, IGF1R
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	1.772E-03	7.457E-03	MET, IGF1R

Showing 1 to 10 of 26 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
C00-D49: Neoplasms	AML	NA	KDR; FLT3;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET; IGF1R; KDR;
C00-D49: Neoplasms	Breast cancer	C50	CDK1; IGF1R; KDR; FLT3;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	IGF1R; KDR; FLT3;
C00-D49: Neoplasms	Colon cancer	C50	FLT3;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	PTGS2;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR; FLT3; PTGS2;

Showing 1 to 10 of 87 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Asplenium septentrionale

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities