CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	OPRD1; NPSR1;
Hydrolase	ACHE;
Protein Kinase	MET; AXL; FLT3; CDK1; PIM1; KDR; IGF1R; AURKB; CSNK2A1;
Lyase	CA2;
Nuclear hormone receptor subfamily 3 group A	ESR2;
Enzyme_unclassified	ALOX12; HSD17B1; HSD17B10; NOX4; POLB;
Aspartic protease	BACE1;
ATP-binding cassette	ABCG2;
Unclassified	THPO;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP19A1; CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Aspartic protease	BACE1	Beta-secretase 1	P56817	CHEMBL4822
ATP-binding cassette	ABCG2	ATP-binding cassette sub-family G member 2	Q9UNQ0	CHEMBL5393
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD17B1	Estradiol 17-beta-dehydrogenase 1	P14061	CHEMBL3181
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375

Showing 1 to 10 of 26 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0046777; protein autophosphorylation	1.966E-07	3.292E-04	AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	2.582E-07	3.748E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0050896; response to stimulus	GO:0010035; response to inorganic substance	1.898E-06	1.148E-03	AXL, CA2, CDK1, CYP1A1, CYP1A2, CYP1B1, KDR
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	2.833E-06	1.542E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0032502; developmental process	GO:0031100; animal organ regeneration	3.098E-06	1.645E-03	AXL, CDK1, CSNK2A1, FLT3
BP	GO:0050896; response to stimulus	GO:0014070; response to organic cyclic compound	3.314E-06	1.718E-03	CA2, CDK1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FLT3, NOX4
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	3.766E-06	1.855E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0018108; peptidyl-tyrosine phosphorylation	4.379E-06	1.870E-03	AXL, FLT3, IGF1R, KDR, MET
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	1.044E-05	3.725E-03	CYP1A1, CYP1A2
BP	GO:0009987; cellular process	GO:0043066; negative regulation of apoptotic process	1.112E-05	3.781E-03	ALOX12, AURKB, AXL, CDK1, CSNK2A1, IGF1R, KDR, PIM1

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.080E-08	4.102E-07	HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP19A1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	1.866E-05	4.728E-04	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.142E-04	1.808E-03	CYP1A2, CYP1A1, CYP1B1
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	3.580E-04	3.887E-03	THPO, FLT3, KDR, MET
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	1.189E-04	1.808E-03	CSNK2A1, MET, IGF1R
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	5.027E-09	3.820E-07	HSD17B1, CYP1A1, CYP1B1, CYP19A1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.613E-04	2.044E-03	CYP1A2, CYP1A1, CYP1B1

Showing 1 to 7 of 7 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR; FLT3;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR;

Showing 1 to 10 of 110 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Crotalaria candicans

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities