Plant Name: Senecio sinuatus
Taxonomic Information:
Plant ID: NPO3868
Plant Latin Name: Senecio sinuatus
Taxonomy Genus: Senecio
Taxonomy Family: Asteraceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
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See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| GPR35; | |
| RECQL; TDP1; HSD11B1; AKR1B10; HPGD; AKR1B1; APEX1; POLB; | |
| CDC25B; | |
| TEK; INSR; MET; EGFR; NUAK1; SRC; KDR; IGF1R; CSNK2A1; | |
| RORC; | |
| NR1H4; | |
| KDM4E; | |
| FUT7; | |
| SLC22A6; SLCO1B3; | |
| SMAD3; LMNA; HSPA1A; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | HSD11B1 | 11-beta-hydroxysteroid dehydrogenase 1 | P28845 | CHEMBL4235 |
| Enzyme_unclassified | AKR1B10 | Aldo-keto reductase family 1 member B10 | O60218 | CHEMBL5983 |
| Enzyme_unclassified | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD+] | P15428 | CHEMBL1293255 |
| Enzyme_unclassified | AKR1B1 | Aldose reductase | P15121 | CHEMBL1900 |
| Enzyme_unclassified | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
| Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Enzyme_unclassified | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Lysine demethylase | KDM4E | Lysine-specific demethylase 4D-like | B2RXH2 | CHEMBL1293226 |
| Nuclear hormone receptor subfamily 1 group F | RORC | Nuclear receptor ROR-gamma | P51449 | CHEMBL1741186 |
Showing 1 to 10 of 28 entries
Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0038083; peptidyl-tyrosine autophosphorylation | 6.456E-09 | 1.354E-05 | EGFR, IGF1R, INSR, KDR, SRC |
| BP | GO:0009987; cellular process | GO:0043066; negative regulation of apoptotic process | 1.321E-08 | 1.797E-05 | AKR1B1, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, LMNA, NR1H4, SMAD3, SRC, TEK |
| BP | GO:0009987; cellular process | GO:0006286; base-excision repair, base-free sugar-phosphate removal | 2.026E-06 | 8.485E-04 | APEX1, POLB |
| BP | GO:0009987; cellular process | GO:0051897; positive regulation of protein kinase B signaling | 2.399E-06 | 9.673E-04 | EGFR, INSR, MET, SRC, TEK |
| BP | GO:0050896; response to stimulus | GO:0009725; response to hormone | 3.019E-06 | 1.114E-03 | AKR1B1, APEX1, CSNK2A1, EGFR, HPGD, INSR, SRC, TEK |
| BP | GO:0009987; cellular process | GO:0007169; transmembrane receptor protein tyrosine kinase signaling pathway | 5.443E-06 | 1.659E-03 | EGFR, IGF1R, INSR, KDR, MET, SRC, TEK |
| BP | GO:0050896; response to stimulus | GO:0014070; response to organic cyclic compound | 6.166E-06 | 1.721E-03 | APEX1, CSNK2A1, EGFR, HPGD, RORC, SLC22A6, SRC, TEK |
| BP | GO:0050896; response to stimulus | GO:1901653; cellular response to peptide | 1.108E-05 | 2.774E-03 | AKR1B1, APEX1, IGF1R, INSR, SRC |
| BP | GO:0050896; response to stimulus | GO:0034614; cellular response to reactive oxygen species | 1.706E-05 | 3.607E-03 | AKR1B1, APEX1, EGFR, SRC |
| BP | GO:0009987; cellular process | GO:0071363; cellular response to growth factor stimulus | 2.440E-05 | 4.580E-03 | EGFR, INSR, KDR, SMAD3, SRC |
Showing 1 to 10 of 24 entries
Enriched KEGG Pathways of Target Proteins (Activity≤1μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 7.621E-27 | 1.197E-24 | CA12, CA1, CA3, CA5B, CA2, CA5A, CA4, CA7, CA6, CA9, CA14, CA13 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00052 | Galactose metabolism | 1.558E-04 | 8.433E-04 | AKR1B10, GAA, AKR1B1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04015 | Rap1 signaling pathway | 1.742E-10 | 6.838E-09 | PDGFRB, SRC, INSR, FLT4, KDR, AKT1, BRAF, TEK, MET, EGFR, IGF1R |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04014 | Ras signaling pathway | 6.367E-09 | 1.999E-07 | PDGFRB, PLA2G1B, INSR, FLT4, KDR, AKT1, TEK, MET, EGFR, IGF1R |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04151 | PI3K-Akt signaling pathway | 2.658E-08 | 4.638E-07 | PDGFRB, GSK3B, INSR, FLT4, KDR, AKT1, TEK, MET, PTK2, EGFR, IGF1R |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04012 | ErbB signaling pathway | 2.214E-08 | 4.638E-07 | GSK3B, SRC, ERBB2, AKT1, BRAF, EGFR, PTK2 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04068 | FoxO signaling pathway | 2.065E-08 | 4.638E-07 | PLK4, SMAD3, INSR, PLK1, AKT1, BRAF, EGFR, IGF1R |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04010 | MAPK signaling pathway | 2.553E-07 | 3.341E-06 | PDGFRB, DUSP3, AKT1, BRAF, MAP3K8, MAPT, EGFR, HSPA1A, CDC25B |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04066 | HIF-1 signaling pathway | 1.617E-06 | 1.693E-05 | INSR, ERBB2, AKT1, TEK, EGFR, IGF1R |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04370 | VEGF signaling pathway | 6.177E-05 | 3.879E-04 | SRC, KDR, AKT1, PTK2 |
Showing 1 to 10 of 47 entries
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Cryptosporidium infection | A07.2 | EGFR; |
| C00-D49: Neoplasms | Advanced solid tumor | C00-C75, C7A, C7B | MET; |
| C00-D49: Neoplasms | Metastatic castration-resistant prostate cancer | C61 | KDR; |
| C00-D49: Neoplasms | Metastatic breast cancer | C50 | KDR; |
| C00-D49: Neoplasms | AML | NA | KDR; |
| C00-D49: Neoplasms | Cancer | C00-C96 | MET; IGF1R; KDR; CSNK2A1; TEK; EGFR; SRC; CDC25B; |
| C00-D49: Neoplasms | Metastatic colorectal cancer | C18-C21 | KDR; EGFR; |
| C00-D49: Neoplasms | Metastatic HER2-negative gastric cancer | NA | MET; |
| C00-D49: Neoplasms | Malignant adrenal gland cancer | C74.0 | IGF1R; |
| C00-D49: Neoplasms | Urethral cancer | NA | EGFR; |
Showing 1 to 10 of 103 entries
>> Profiles of ingredients and activity landscape
>> Collective molecular activities profile at 10μM cutoff
>> Targets derived from weak experimental activities
