Plant Name: Pimpinella magna
Taxonomic Information:
Plant ID: NPO3858
Plant Latin Name: Pimpinella magna
Taxonomy Genus: Pimpinella
Taxonomy Family: Apiaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: | CYP3A4; |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cysteine protease | CTSB | Cathepsin B | P07858 | CHEMBL4072 |
| Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Serine protease | CTSG | Cathepsin G | P08311 | CHEMBL4071 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0042445; hormone metabolic process | 5.405E-04 | 5.636E-01 | CTSG, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0009822; alkaloid catabolic process | 6.212E-04 | 5.636E-01 | CYP3A4 |
| CC | GO:0044464; cell part | GO:0036464; cytoplasmic ribonucleoprotein granule | 5.405E-04 | 5.636E-01 | CTSG, MAPT |
| MF | GO:0003824; catalytic activity | GO:0070576; vitamin D 24-hydroxylase activity | 6.212E-04 | 5.636E-01 | CYP3A4 |
| CC | GO:0044464; cell part | GO:0036021; endolysosome lumen | 1.035E-03 | 6.092E-01 | CTSB |
| MF | GO:0003824; catalytic activity | GO:0034875; caffeine oxidase activity | 8.281E-04 | 6.092E-01 | CYP3A4 |
| CC | GO:0044464; cell part | GO:0030673; axolemma | 3.309E-03 | 9.482E-01 | MAPT |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09140 Cellular Processes | 09141 Transport and catabolism | hsa04142 | Lysosome | 2.233E-04 | 4.242E-03 | CTSG, CTSB |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04614 | Renin-angiotensin system | 4.592E-03 | 2.581E-02 | CTSG |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 5.788E-03 | 2.581E-02 | CYP3A4 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04924 | Renin secretion | 1.274E-02 | 2.581E-02 | CTSB |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00140 | Steroid hormone biosynthesis | 1.155E-02 | 2.581E-02 | CYP3A4 |
| 09100 Metabolism | 09108 Metabolism of cofactors and vitamins | hsa00830 | Retinol metabolism | 1.294E-02 | 2.581E-02 | CYP3A4 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 1.373E-02 | 2.581E-02 | CYP3A4 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 1.452E-02 | 2.581E-02 | CYP3A4 |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 1.413E-02 | 2.581E-02 | CYP3A4 |
| 09150 Organismal Systems | 09151 Immune system | hsa04612 | Antigen processing and presentation | 1.531E-02 | 2.581E-02 | CTSB |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| G00-G99: Diseases of the nervous system G00-G99 | Neurodegenerative disease | G30-G32 | MAPT; |
| G00-G99: Diseases of the nervous system G00-G99 | Central nervous system disease | G00-G99 | MAPT; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cognitive disorders | F01-F07, F04, F05, R41.3 | MAPT; |
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | MAPT; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
