CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Serine protease	CTSG;
Cysteine protease	CTSB;
Unclassified	MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cysteine protease	CTSB	Cathepsin B	P07858	CHEMBL4072
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Serine protease	CTSG	Cathepsin G	P08311	CHEMBL4071
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0042445; hormone metabolic process	5.405E-04	5.636E-01	CTSG, CYP3A4
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	6.212E-04	5.636E-01	CYP3A4
CC	GO:0044464; cell part	GO:0036464; cytoplasmic ribonucleoprotein granule	5.405E-04	5.636E-01	CTSG, MAPT
CC	GO:0044464; cell part	GO:0036021; endolysosome lumen	1.035E-03	6.092E-01	CTSB
CC	GO:0044464; cell part	GO:0030673; axolemma	3.309E-03	9.482E-01	MAPT
MF	GO:0003824; catalytic activity	GO:0070576; vitamin D 24-hydroxylase activity	6.212E-04	5.636E-01	CYP3A4
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	8.281E-04	6.092E-01	CYP3A4

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	5.788E-03	2.581E-02	CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.155E-02	2.581E-02	CYP3A4
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.294E-02	2.581E-02	CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.373E-02	2.581E-02	CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.452E-02	2.581E-02	CYP3A4
09140 Cellular Processes	09141 Transport and catabolism	hsa04142	Lysosome	2.233E-04	4.242E-03	CTSG, CTSB
09150 Organismal Systems	09152 Endocrine system	hsa04614	Renin-angiotensin system	4.592E-03	2.581E-02	CTSG
09150 Organismal Systems	09152 Endocrine system	hsa04924	Renin secretion	1.274E-02	2.581E-02	CTSB
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	1.413E-02	2.581E-02	CYP3A4
09150 Organismal Systems	09151 Immune system	hsa04612	Antigen processing and presentation	1.531E-02	2.581E-02	CTSB

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Pimpinella magna

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities