CMAUP Plant Collective Molecular Activities

Plant Name: Melia indica

Taxonomic Information:

Plant ID: NPO3846
Plant Latin Name: Melia indica
Taxonomy Genus: Melia
Taxonomy Family: Meliaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Kinase	FYN; LCK; MAPK1; MAPK14;
Lyase	CA2; CA7; CA4; CA12;
SLC superfamily of solute carriers	SLCO1B1;
Methyl-lysine/arginine binding protein	L3MBTL1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	TBXAS1; CYP1A2;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 5	TBXAS1	Thromboxane-A synthase	P24557	CHEMBL1835
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Methyl-lysine/arginine binding protein	L3MBTL1	Lethal(3)malignant brain tumor-like protein 1	Q9Y468	CHEMBL1287622
Protein Kinase	FYN	Tyrosine-protein kinase FYN	P06241	CHEMBL1841
Protein Kinase	LCK	Tyrosine-protein kinase LCK	P06239	CHEMBL258
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Protein Kinase	MAPK14	MAP kinase p38 alpha	Q16539	CHEMBL260
SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.161E-10	2.528E-06	CA12, CA2, CA4, CA7
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	4.975E-09	5.417E-05	CA12, CA2, CA4, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.144E-08	8.300E-05	CA12, CA2, CA4, CA7
MF	GO:0005488; binding	GO:0042610; CD8 receptor binding	3.538E-07	1.101E-03	FYN, LCK
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.061E-06	2.567E-03	CA2, CA7
MF	GO:0005488; binding	GO:0046914; transition metal ion binding	9.787E-07	2.567E-03	CA12, CA2, CA4, CA7, CYP1A2, L3MBTL1, TBXAS1
BP	Unclassified;	GO:2000021; regulation of ion homeostasis	6.043E-06	8.773E-03	CA2, CA7, FYN, LCK
MF	GO:0005488; binding	GO:0042608; T cell receptor binding	7.417E-06	9.500E-03	FYN, LCK
MF	GO:0005488; binding	GO:0042609; CD4 receptor binding	7.417E-06	9.500E-03	FYN, LCK

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.760E-10	2.024E-08	CA12, CA2, CA4, CA7
09150 Organismal Systems	09151 Immune system	hsa04660	T cell receptor signaling pathway	3.307E-07	1.902E-05	LCK, MAPK1, FYN, MAPK14
09150 Organismal Systems	09151 Immune system	hsa04611	Platelet activation	6.281E-07	2.408E-05	TBXAS1, MAPK1, FYN, MAPK14
09150 Organismal Systems	09158 Development	hsa04380	Osteoclast differentiation	8.613E-07	2.476E-05	LCK, MAPK1, FYN, MAPK14
09150 Organismal Systems	09151 Immune system	hsa04664	Fc epsilon RI signaling pathway	8.091E-06	1.861E-04	MAPK1, FYN, MAPK14
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	4.455E-05	8.539E-04	MAPK1, FYN, MAPK14
09150 Organismal Systems	09151 Immune system	hsa04650	Natural killer cell mediated cytotoxicity	6.329E-05	1.040E-03	LCK, MAPK1, FYN
09130 Environmental Information Processing	09132 Signal transduction	hsa04370	VEGF signaling pathway	5.922E-04	6.046E-03	MAPK1, MAPK14
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05020	Prion diseases	1.942E-04	2.482E-03	MAPK1, FYN
09150 Organismal Systems	09151 Immune system	hsa04621	NOD-like receptor signaling pathway	5.171E-04	5.947E-03	MAPK1, MAPK14
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	8.241E-04	6.046E-03	MAPK1, MAPK14
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	8.291E-05	1.192E-03	CA2, CA4
09160 Human Diseases	09167 Infectious diseases	hsa05140	Leishmaniasis	8.470E-04	6.046E-03	MAPK1, MAPK14
09160 Human Diseases	09167 Infectious diseases	hsa05131	Shigellosis	6.722E-04	6.046E-03	MAPK1, MAPK14
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	8.014E-04	6.046E-03	SLCO1B1, CA2
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	8.702E-04	6.046E-03	MAPK1, FYN
09150 Organismal Systems	09152 Endocrine system	hsa04912	GnRH signaling pathway	1.312E-03	7.941E-03	MAPK1, MAPK14
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	1.612E-03	8.429E-03	MAPK1, MAPK14
09150 Organismal Systems	09152 Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1.519E-03	8.429E-03	MAPK1, MAPK14
09150 Organismal Systems	09156 Nervous system	hsa04723	Retrograde endocannabinoid signaling	1.612E-03	8.429E-03	MAPK1, MAPK14
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	8.938E-04	6.046E-03	MAPK1, MAPK14
09150 Organismal Systems	09156 Nervous system	hsa04725	Cholinergic synapse	1.943E-03	8.593E-03	MAPK1, FYN
09160 Human Diseases	09167 Infectious diseases	hsa05132	Salmonella infection	1.173E-03	7.494E-03	MAPK1, MAPK14
09150 Organismal Systems	09151 Immune system	hsa04620	Toll-like receptor signaling pathway	1.774E-03	8.500E-03	MAPK1, MAPK14
09130 Environmental Information Processing	09132 Signal transduction	hsa04668	TNF signaling pathway	1.908E-03	8.593E-03	MAPK1, MAPK14
09160 Human Diseases	09167 Infectious diseases	hsa05142	Chagas disease (American trypanosomiasis)	1.708E-03	8.500E-03	MAPK1, MAPK14
09160 Human Diseases	09167 Infectious diseases	hsa05145	Toxoplasmosis	2.192E-03	9.304E-03	MAPK1, MAPK14
09150 Organismal Systems	09156 Nervous system	hsa04722	Neurotrophin signaling pathway	2.265E-03	9.304E-03	MAPK1, MAPK14

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
I00-I99: Diseases of the circulatory system	Cardiac arrhythmias	I47-I49	TBXAS1;
NA: NA	Rheumatold arthritis	NA	MAPK14;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	MAPK14;
C00-D49: Neoplasms	Cancer	C00-C96	MAPK1; MAPK14;
J00-J99: Diseases of the respiratory system	Acute lung injury	J80	MAPK14;
I00-I99: Diseases of the circulatory system	Angina pectoris	I20	TBXAS1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	TBXAS1;
I00-I99: Diseases of the circulatory system	Acute coronary syndrome	I74	MAPK14;
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	MAPK14; TBXAS1;
NA: NA	Inflammatory diseases	NA	MAPK14;
N00-N99: Diseases of the genitourinary system	Nephritis	N00-N19, N25-N29	TBXAS1;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	MAPK14;
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	MAPK14;
J00-J99: Diseases of the respiratory system	Asthma	J45	TBXAS1;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4; CA2;
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	LCK;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
I00-I99: Diseases of the circulatory system	Coronary artery disease	I20-I25	MAPK14;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
NA: NA	Edema	NA	CA2;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
I00-I99: Diseases of the circulatory system	Thromboembolism	I80-I82	TBXAS1;
C00-D49: Neoplasms	Solid tumours	C00-D48	MAPK1;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	MAPK14;
H00-H59: Diseases of the eye and adnexa	Diabetic retinopathy	H36, E10.3, E11.3, E13.3	MAPK14;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	MAPK14;
NA: NA	Acute respiratory distress syndrome	NA	MAPK14;
I00-I99: Diseases of the circulatory system	Thrombosis	I80-I82	TBXAS1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases