CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	NPSR1;
Enzyme_unclassified	RECQL; TDP1; GLO1; ALOX12; HSD17B2; HSD17B10; NOX4; APEX1; POLB;
Hydrolase	ACHE;
Isomerase	TOP2A;
Protein Kinase	MET; AXL; FLT3; CDK1; PIM1; KDR; CDK8; IGF1R; AURKB;
Lyase	CA2; CA12; CA7; CA4;
Oxidoreductase	TYR;
Transcription Factor	AHR; HIF1A;
Methyl-lysine/arginine binding protein	L3MBTL1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C19; CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	GLO1	Glyoxalase I	Q04760	CHEMBL2424
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD17B2	Estradiol 17-beta-dehydrogenase 2	P37059	CHEMBL2789
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.471E-09	8.009E-06	CYP1A1, CYP1A2, CYP1B1, CYP2C19
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	4.138E-08	5.300E-05	CYP1A1, CYP1A2, CYP1B1, CYP2C19
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	4.000E-07	2.903E-04	CA12, CA2, CA4, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	9.130E-07	5.232E-04	CA12, CA2, CA4, CA7
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	1.564E-06	7.738E-04	ALOX12, APEX1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, HSD17B10, HSD17B2, NOX4, TYR
BP	GO:0032502; developmental process	GO:0007568; aging	2.317E-06	1.051E-03	APEX1, AURKB, CDK1, CYP1A1, NOX4, POLB
BP	GO:0009987; cellular process	GO:0006286; base-excision repair, base-free sugar-phosphate removal	2.830E-06	1.185E-03	APEX1, POLB
BP	GO:0009987; cellular process	GO:0070301; cellular response to hydrogen peroxide	3.439E-06	1.410E-03	APEX1, AXL, CDK1, CYP1B1
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	7.860E-06	2.674E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	8.482E-06	2.798E-03	CA2, CA7

Showing 1 to 10 of 25 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.439E-08	1.022E-06	CA12, CA2, CA4, CA7
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2.447E-06	5.791E-05	CYP1A2, HSD17B2, CYP1A1, CYP1B1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	3.879E-05	5.508E-04	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2.353E-04	2.386E-03	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.042E-03	7.401E-03	CYP1A2, CYP2C19
09120 Genetic Information Processing	09124 Replication and repair	hsa03410	Base excision repair	1.350E-03	8.714E-03	POLB, APEX1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	1.340E-06	4.759E-05	HSD17B2, CYP1A1, CYP1B1, IGF1R
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	6.536E-04	5.156E-03	CA2, CA4
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	9.810E-06	1.741E-04	CYP1A2, CYP1A1, CYP1B1, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	1.824E-04	2.159E-03	FLT3, MET, HIF1A

Showing 1 to 10 of 11 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET; IGF1R; KDR;
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Euphorbia myrsinites

Taxonomic Information:

Plant External Links:

Used in Medicines:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities