CMAUP Plant Collective Molecular Activities

Plant Name: Eucalyptus cladocalyx

Taxonomic Information:

Plant ID: NPO3809
Plant Latin Name: Eucalyptus cladocalyx
Taxonomy Genus: Eucalyptus
Taxonomy Family: Myrtaceae

Plant External Links:

NCBI TaxonomyDB: 452569
Plant-of-the-World-Online: 592800-1

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

Australia; South Africa; Tanzania; United States; Morocco; Trinidad and Tobago; China; Kenya

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADORA3; ADORA2A; ADORA1;
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	RECQL; FAAH; TDP1; CDA; ADK; ALDH1A1;
Lyase	CA2; CA1; CA12; CA9; CA14; CA7;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD;
Nuclear hormone receptor subfamily 3 group A	ESR2;
Transcription Factor	STAT6;
SLC superfamily of solute carriers	SLC28A2; SLC28A1; SLC28A3;
Unclassified	LMNA;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4; CYP2A6;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2A6	Cytochrome P450 2A6	P11509	CHEMBL5282
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	FAAH	Anandamide amidohydrolase	O00519	CHEMBL2243
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	CDA	Cytidine deaminase	P32320	CHEMBL4502
Enzyme_unclassified	ADK	Adenosine kinase	P55263	CHEMBL3589
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
SLC superfamily of solute carriers	SLC28A2	Sodium/nucleoside cotransporter 2	O43868	CHEMBL5780
SLC superfamily of solute carriers	SLC28A1	Sodium/nucleoside cotransporter 1	O00337	CHEMBL5551
SLC superfamily of solute carriers	SLC28A3	Solute carrier family 28 member 3	Q9HAS3	CHEMBL5707
Small molecule receptor (family A GPCR)	ADORA3	Adenosine A3 receptor	P0DMS8	CHEMBL256
Small molecule receptor (family A GPCR)	ADORA2A	Adenosine A2a receptor	P29274	CHEMBL251
Small molecule receptor (family A GPCR)	ADORA1	Adenosine A1 receptor	P30542	CHEMBL226
Transcription Factor	STAT6	Signal transducer and activator of transcription 6	P42226	CHEMBL5401
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.593E-14	5.646E-10	CA1, CA12, CA14, CA2, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	3.555E-11	3.870E-07	CA1, CA12, CA14, CA2, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.604E-09	6.986E-06	CA1, CA12, CA2, CA7, CA9
MF	GO:0060089; molecular transducer activity	GO:0001609; G-protein coupled adenosine receptor activity	9.510E-08	1.736E-04	ADORA1, ADORA2A, ADORA3
BP	GO:0009987; cellular process	GO:0001973; adenosine receptor signaling pathway	2.278E-07	2.918E-04	ADORA1, ADORA2A, ADORA3
BP	GO:0023052; signaling	GO:0032230; positive regulation of synaptic transmission, GABAergic	7.726E-07	8.854E-04	ADORA2A, CA2, CA7
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.331E-06	1.383E-03	CA1, CA12, CA2, CA7, CA9, CDA, ESR2, PPARA, PPARD
BP	GO:0051179; localization	GO:0015860; purine nucleoside transmembrane transport	2.026E-06	1.838E-03	SLC28A2, SLC28A3
MF	GO:0005215; transporter activity	GO:0015389; pyrimidine- and adenine-specific:sodium symporter activity	2.026E-06	1.838E-03	SLC28A1, SLC28A3
MF	GO:0005215; transporter activity	GO:0015211; purine nucleoside transmembrane transporter activity	2.026E-06	1.838E-03	SLC28A2, SLC28A3
BP	GO:0051179; localization	GO:1904823; purine nucleobase transmembrane transport	6.074E-06	3.933E-03	SLC28A1, SLC28A3
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	6.074E-06	3.933E-03	CA2, CA7
BP	GO:0051179; localization	GO:0015855; pyrimidine nucleobase transport	6.074E-06	3.933E-03	SLC28A1, SLC28A3
CC	GO:0044464; cell part	GO:0099056; integral component of presynaptic membrane	6.074E-06	3.933E-03	ADORA1, ADORA2A
CC	GO:0044456; synapse part	GO:0099055; integral component of postsynaptic membrane	7.249E-05	2.923E-02	ADORA1, ADORA2A
CC	GO:0043226; organelle	GO:0097504; Gemini of coiled bodies	1.325E-04	4.581E-02	SMN1, SMN2
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	1.422E-04	4.839E-02	ADORA1, CA2, CA9, TSHR

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	5.195E-14	2.649E-12	CA12, CA1, CA2, CA7, CA9, CA14
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	3.583E-05	9.136E-04	CDA, CYP2A6, CYP3A4
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.013E-04	1.722E-03	CYP2A6, ALDH1A1, CYP3A4
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	1.615E-04	2.059E-03	ADORA2A, ADORA1, PPARA, TSHR
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	5.673E-04	5.786E-03	ADORA2A, ADORA3, ADORA1, TSHR
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2.778E-03	2.361E-02	ADORA1, TSHR
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4.184E-03	2.382E-02	CYP2A6, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4.671E-03	2.382E-02	CYP2A6, CYP3A4
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	4.184E-03	2.382E-02	PPARA, PPARD
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	4.425E-03	2.382E-02	CA2, CYP3A4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
NA: NA	Hepatitis C virus infection	NA	ADORA3;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	ADORA3;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ADORA1; ADORA2A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ADORA1;
L00-L99: Diseases of the skin and subcutaneous tissue	Diabetic foot ulcer	L88-L89	ADORA2A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	FAAH;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	ADORA3;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Convulsions	R56.0	ADK;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	ADORA1;
I00-I99: Diseases of the circulatory system	Orthostatic hypotension	I95.1	ADORA1;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	ADORA1;
C00-D49: Neoplasms	Cancer	C00-C96	ADORA3;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	FAAH;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Radionuclide imaging	W88	ADORA2A;
I00-I99: Diseases of the circulatory system	Cardiac arrhythmias	I47-I49	ADORA1;
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	ADORA3;
I00-I99: Diseases of the circulatory system	Acute and chronic heart failure	I50	ADORA1;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	FAAH; ADORA2A; ADK;
C00-D49: Neoplasms	Solid tumours	C00-D48	CDA;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ADORA1; ADORA2A; ADORA3;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	ADORA1; ADORA2A;
A00-B99: Certain infectious and parasitic diseases	Sepsis	A40, A41	ADORA1;
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	ADORA1;
E00-E89: Endocrine, nutritional and metabolic diseases	Atrial fibrillation	E78, I48	ADORA1;
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	ADORA1;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypertriglyceridemia	E78.1, E78.2, E78.3, I47-I49	ADORA1;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3;
I00-I99: Diseases of the circulatory system	Coronary disorder diagnosis	I20-I25	ADORA2A;
N00-N99: Diseases of the genitourinary system	Renal failure	N17, N18, N19	ADORA1;
J00-J99: Diseases of the respiratory system	Asthma	J45	ADORA1; ADORA2A;
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	ADORA2A;
I00-I99: Diseases of the circulatory system	Cardiac disease	I00-I99	ADORA1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Fatigue	R53	ADORA1;
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	ADORA1;
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	ADORA2A;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	ADORA1; ADORA2A;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ADORA3;
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	ADK;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ADK;
I00-I99: Diseases of the circulatory system	Heart failure	I50	ADORA1;
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	FAAH;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	FAAH;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Anesthesia	R20.0	FAAH;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	ADORA2A;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases