CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	HTR7; HTR5A; FFAR1; FFAR4; ADRA2C;
Enzyme_unclassified	ALPL; ALOX15;
Protein Phosphatase	CDC25B;
Protein Kinase	DYRK1B; DYRK2; CLK1; DYRK3; DYRK1A; HASPIN;
Lyase	CA2; CA12; CA7; CA4;
Nuclear hormone receptor subfamily 1 group C	PPARA;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Oxidoreductase	MAOA;
Transcription Factor	NFKB1;
SLC superfamily of solute carriers	SLCO1B1;
Unclassified	LMNA; FABP3; FABP5; FABP4; NISCH; MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	3.520E-07	1.095E-03	CA12, CA2, CA4, CA7
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	4.917E-07	1.338E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	8.037E-07	1.591E-03	CA12, CA2, CA4, CA7
BP	GO:0065007; biological regulation	GO:0010817; regulation of hormone levels	1.326E-06	2.062E-03	ADRA2C, CYP1A1, CYP1B1, FFAR1, FFAR4, NFKB1, NR1H4, SLCO1B1
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	5.383E-06	5.581E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	7.151E-06	6.488E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	7.968E-06	6.584E-03	CA2, CA7
BP	GO:0050896; response to stimulus	GO:0009725; response to hormone	9.052E-06	6.958E-03	ALPL, CA2, CYP1A2, FABP3, FFAR4, HTR5A, NFKB1, PPARA
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	9.266E-06	6.958E-03	FABP3, FABP4, FABP5
BP	GO:0008152; metabolic process	GO:0018108; peptidyl-tyrosine phosphorylation	1.279E-05	8.193E-03	CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5.283E-06	1.049E-04	CYP2D6, CYP1A2, CYP1A1, CYP1B1, CYP3A4
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.984E-07	1.383E-05	CA12, CA2, CA4, CA7
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	2.887E-06	8.025E-05	PLA2G1B, CYP1A2, ALOX15, CYP3A4
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	1.080E-05	1.876E-04	MAOA, CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4.783E-05	6.648E-04	CYP1A2, CYP1A1, CYP1B1, CYP3A4
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	7.495E-05	9.471E-04	CYP1A2, ALDH1A1, CYP1A1, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	9.471E-05	1.097E-03	MAOA, CYP2D6, CYP1A2, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	1.285E-03	9.400E-03	PLA2G1B, ALOX15, PTGS1
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	1.165E-04	1.246E-03	CYP1A2, XDH
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	4.515E-07	1.569E-05	HTR6, HTR7, HTR2C, ADRB2, HTR5A, ADRA2C, ADRA2B, ADRA2A, TSHR

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Anthelmintic	B89	ALPL;
C00-D49: Neoplasms	Colon cancer	C50	ALPL;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1; CDC25B;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	FFAR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1; FFAR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	ADRA2C;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	FFAR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	ADRA2C;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	MAOA;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Elaeagnus angustifolia

Taxonomic Information:

Plant External Links:

Used in Medicines:

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Traditional Medicine System:

Medicinal Functions:

Geographical Distribution:

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Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities