Plant ID: NPO3806
Plant Latin Name: Garcinia morella
Taxonomy Genus: Garcinia
Taxonomy Family: Clusiaceae
NCBI TaxonomyDB:
1585849
Plant-of-the-World-Online:
428102-1
Bangladesh; Philippines; India; Trinidad and Tobago; China; Sri Lanka; Thailand
GPR35; | |
ALPL; TDP1; BLM; ALOX12; IDH1; HSD17B10; ALOX15; USP2; APEX1; POLB; | |
GAA; | |
PTPRS; | |
IKBKB; DAPK1; | |
ESR2; | |
TP53; RELA; NFKB1; | |
SLC22A12; | |
TXN2; TXN; LMNA; XBP1; MCL1; MAPT; THPO; | |
FASN; | |
SMN1;SMN2; |
Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|
Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
Enzyme_unclassified | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P05186 | CHEMBL5979 |
Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
Enzyme_unclassified | BLM | Bloom syndrome protein | P54132 | CHEMBL1293237 |
Enzyme_unclassified | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
Enzyme_unclassified | IDH1 | Isocitrate dehydrogenase [NADP] cytoplasmic | O75874 | CHEMBL2007625 |
Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
Enzyme_unclassified | USP2 | Ubiquitin carboxyl-terminal hydrolase 2 | O75604 | CHEMBL1293227 |
Enzyme_unclassified | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
Hydrolase | GAA | Lysosomal alpha-glucosidase | P10253 | CHEMBL2608 |
Methyl-lysine/arginine binding protein | SMN1;SMN2 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
Nuclear hormone receptor subfamily 3 group A | ESR2 | Estrogen receptor beta | Q92731 | CHEMBL242 |
Protein Kinase | IKBKB | Inhibitor of nuclear factor kappa B kinase beta subunit | O14920 | CHEMBL1991 |
Protein Kinase | DAPK1 | Death-associated protein kinase 1 | P53355 | CHEMBL2558 |
Protein Phosphatase | PTPRS | Receptor-type tyrosine-protein phosphatase S | Q13332 | CHEMBL2396508 |
SLC superfamily of solute carriers | SLC22A12 | Solute carrier family 22 member 12 | Q96S37 | CHEMBL6120 |
Small molecule receptor (family A GPCR) | GPR35 | G-protein coupled receptor 35 | Q9HC97 | CHEMBL1293267 |
Transcription Factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
Transcription Factor | RELA | Nuclear factor NF-kappa-B p65 subunit | Q04206 | CHEMBL5533 |
Transcription Factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
Transferase | FASN | Fatty acid synthase | P49327 | CHEMBL4158 |
Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
Unclassified | THPO | Thrombopoietin | P40225 | CHEMBL1293256 |
Unclassified | TXN2 | Thioredoxin, mitochondrial | Q99757 | CHEMBL2189153 |
Unclassified | TXN | Thioredoxin | P10599 | CHEMBL2010624 |
Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Unclassified | XBP1 | X-box-binding protein 1 | P17861 | CHEMBL1741176 |
Unclassified | MCL1 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Q07820 | CHEMBL4361 |
GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|
BP | GO:0008152; metabolic process | GO:0055114; oxidation-reduction process | 1.361E-08 | 9.878E-05 | ALOX12, ALOX15, APEX1, CYP19A1, CYP2C19, CYP2C9, FASN, GAA, HSD17B10, IDH1, TXN, TXN2 |
MF | GO:0003824; catalytic activity | GO:0016491; oxidoreductase activity | 1.886E-08 | 1.026E-04 | ALOX12, ALOX15, APEX1, CYP19A1, CYP2C19, CYP2C9, FASN, HSD17B10, IDH1, TXN, TXN2 |
BP | GO:0009987; cellular process | GO:0034599; cellular response to oxidative stress | 8.395E-07 | 1.828E-03 | APEX1, DAPK1, RELA, TP53, TXN, TXN2 |
BP | GO:0009987; cellular process | GO:0006286; base-excision repair, base-free sugar-phosphate removal | 2.830E-06 | 2.465E-03 | APEX1, POLB |
BP | GO:0008152; metabolic process | GO:2001303; lipoxin A4 biosynthetic process | 2.830E-06 | 2.465E-03 | ALOX12, ALOX15 |
MF | GO:0003824; catalytic activity | GO:0047977; hepoxilin-epoxide hydrolase activity | 2.830E-06 | 2.465E-03 | ALOX12, ALOX15 |
BP | GO:0032502; developmental process | GO:0048856; anatomical structure development | 4.421E-06 | 3.320E-03 | ALOX15, ALPL, CYP19A1, FASN, GAA, IDH1, LMNA, MCL1, POLB, PTPRS, RELA, SMN1, SMN2, THPO, TP53, USP2, XBP1 |
MF | GO:0005488; binding | GO:0003684; damaged DNA binding | 5.015E-06 | 3.522E-03 | APEX1, BLM, POLB, TP53 |
MF | GO:0005488; binding | GO:0005506; iron ion binding | 7.207E-06 | 4.756E-03 | ALOX12, ALOX15, CYP19A1, CYP2C19, CYP2C9 |
MF | GO:0003824; catalytic activity | GO:0004052; arachidonate 12-lipoxygenase activity | 8.482E-06 | 4.992E-03 | ALOX12, ALOX15 |
MF | GO:0003824; catalytic activity | GO:0051120; hepoxilin A3 synthase activity | 8.482E-06 | 4.992E-03 | ALOX12, ALOX15 |
BP | GO:0050896; response to stimulus | GO:0007584; response to nutrient | 1.788E-05 | 7.633E-03 | ALPL, RELA, TP53, TXN2, XBP1 |
BP | GO:0050896; response to stimulus | GO:0014070; response to organic cyclic compound | 2.331E-05 | 8.836E-03 | ALPL, APEX1, BLM, IDH1, NFKB1, RELA, TP53, TXN2 |
BP | GO:0009987; cellular process | GO:2001237; negative regulation of extrinsic apoptotic signaling pathway | 2.770E-05 | 8.836E-03 | DAPK1, LMNA, MCL1, RELA |
BP | GO:0008152; metabolic process | GO:0051122; hepoxilin biosynthetic process | 2.821E-05 | 8.836E-03 | ALOX12, ALOX15 |
BP | GO:0008152; metabolic process | GO:2000630; positive regulation of miRNA metabolic process | 2.821E-05 | 8.836E-03 | NFKB1, RELA |
MF | GO:0003824; catalytic activity | GO:0008395; steroid hydroxylase activity | 2.622E-05 | 8.836E-03 | CYP19A1, CYP2C19, CYP2C9 |
CC | GO:0044464; cell part | GO:0005737; cytoplasm | 3.340E-05 | 9.696E-03 | ALOX12, APEX1, BLM, DAPK1, HSD17B10, IDH1, MAPT, MCL1, NFKB1, POLB, RELA, SMN1, SMN2, TDP1, TP53, TXN, USP2, XBP1 |
CC | GO:0044464; cell part | GO:0005739; mitochondrion | 3.868E-05 | 1.094E-02 | APEX1, ESR2, FASN, HSD17B10, IDH1, MCL1, NFKB1, TP53, TXN, TXN2 |
CC | GO:0032991; macromolecular complex | GO:0033256; I-kappaB/NF-kappaB complex | 5.912E-05 | 1.446E-02 | NFKB1, RELA |
CC | GO:0043226; organelle | GO:0097504; Gemini of coiled bodies | 1.848E-04 | 3.367E-02 | SMN1, SMN2 |
CC | GO:0032991; macromolecular complex | GO:0032797; SMN complex | 2.182E-04 | 3.741E-02 | SMN1, SMN2 |
Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|---|
09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 1.001E-07 | 1.112E-05 | IKBKB, LMNA, TP53, RELA, NFKB1, MCL1 |
09100 Metabolism | 09103 Lipid metabolism | hsa00590 | Arachidonic acid metabolism | 3.202E-06 | 1.143E-04 | CYP2C9, ALOX15, ALOX12, CYP2C19 |
09160 Human Diseases | 09167 Infectious diseases | hsa05166 | HTLV-I infection | 3.595E-06 | 1.143E-04 | IKBKB, POLB, XBP1, TP53, RELA, NFKB1 |
09160 Human Diseases | 09161 Cancers | hsa05212 | Pancreatic cancer | 4.118E-06 | 1.143E-04 | IKBKB, TP53, RELA, NFKB1 |
09160 Human Diseases | 09161 Cancers | hsa05220 | Chronic myeloid leukemia | 6.168E-06 | 1.369E-04 | IKBKB, TP53, RELA, NFKB1 |
09160 Human Diseases | 09161 Cancers | hsa05215 | Prostate cancer | 1.358E-05 | 2.015E-04 | IKBKB, TP53, RELA, NFKB1 |
Unclassified | Unclassified | hsa01100 | Metabolic pathways | 1.998E-05 | 2.464E-04 | CYP2C9, FASN, GAA, IDH1, ALOX15, ALPL, ALOX12, CYP2C19, CYP19A1, HSD17B10 |
09160 Human Diseases | 09161 Cancers | hsa05222 | Small cell lung cancer | 1.185E-05 | 2.015E-04 | IKBKB, TP53, RELA, NFKB1 |
09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 3.364E-05 | 3.734E-04 | CYP2C9, ALOX15, ALOX12, CYP2C19 |
09130 Environmental Information Processing | 09132 Signal transduction | hsa04010 | MAPK signaling pathway | 5.742E-05 | 5.312E-04 | IKBKB, MAPT, TP53, RELA, NFKB1 |
09150 Organismal Systems | 09156 Nervous system | hsa04722 | Neurotrophin signaling pathway | 4.408E-05 | 4.448E-04 | IKBKB, TP53, RELA, NFKB1 |
09160 Human Diseases | 09167 Infectious diseases | hsa05161 | Hepatitis B | 9.458E-05 | 7.358E-04 | IKBKB, TP53, RELA, NFKB1 |
09160 Human Diseases | 09167 Infectious diseases | hsa05160 | Hepatitis C | 6.585E-05 | 5.623E-04 | IKBKB, TP53, RELA, NFKB1 |
09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04932 | Non-alcoholic fatty liver disease (NAFLD) | 1.077E-04 | 7.358E-04 | IKBKB, XBP1, RELA, NFKB1 |
09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 1.452E-05 | 2.015E-04 | CYP2C9, ALOX15, CYP2C19 |
09130 Environmental Information Processing | 09132 Signal transduction | hsa04151 | PI3K-Akt signaling pathway | 2.243E-04 | 1.004E-03 | IKBKB, TP53, RELA, NFKB1, MCL1 |
09160 Human Diseases | 09161 Cancers | hsa05221 | Acute myeloid leukemia | 1.127E-04 | 7.358E-04 | IKBKB, RELA, NFKB1 |
09150 Organismal Systems | 09151 Immune system | hsa04621 | NOD-like receptor signaling pathway | 1.127E-04 | 7.358E-04 | IKBKB, RELA, NFKB1 |
09160 Human Diseases | 09167 Infectious diseases | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 1.906E-04 | 1.004E-03 | IKBKB, RELA, NFKB1 |
09160 Human Diseases | 09161 Cancers | hsa05200 | Pathways in cancer | 4.511E-04 | 1.727E-03 | IKBKB, DAPK1, TP53, NFKB1, RELA |
09160 Human Diseases | 09167 Infectious diseases | hsa05169 | Epstein-Barr virus infection | 3.286E-04 | 1.351E-03 | IKBKB, TP53, RELA, NFKB1 |
09160 Human Diseases | 09161 Cancers | hsa05203 | Viral carcinogenesis | 3.475E-04 | 1.377E-03 | POLB, TP53, RELA, NFKB1 |
09160 Human Diseases | 09167 Infectious diseases | hsa05168 | Herpes simplex infection | 2.351E-04 | 1.004E-03 | IKBKB, TP53, RELA, NFKB1 |
09150 Organismal Systems | 09152 Endocrine system | hsa04917 | Prolactin signaling pathway | 2.259E-04 | 1.004E-03 | RELA, NFKB1, ESR2 |
09150 Organismal Systems | 09152 Endocrine system | hsa04920 | Adipocytokine signaling pathway | 2.078E-04 | 1.004E-03 | IKBKB, RELA, NFKB1 |
09150 Organismal Systems | 09151 Immune system | hsa04623 | Cytosolic DNA-sensing pathway | 1.592E-04 | 9.740E-04 | IKBKB, RELA, NFKB1 |
09150 Organismal Systems | 09151 Immune system | hsa04662 | B cell receptor signaling pathway | 2.353E-04 | 1.004E-03 | IKBKB, RELA, NFKB1 |
09160 Human Diseases | 09167 Infectious diseases | hsa05131 | Shigellosis | 1.667E-04 | 9.740E-04 | IKBKB, RELA, NFKB1 |
09150 Organismal Systems | 09151 Immune system | hsa04622 | RIG-I-like receptor signaling pathway | 2.078E-04 | 1.004E-03 | IKBKB, RELA, NFKB1 |
09150 Organismal Systems | 09149 Aging | hsa04211 | Longevity regulating pathway - mammal | 4.953E-04 | 1.773E-03 | TP53, RELA, NFKB1 |
09150 Organismal Systems | 09151 Immune system | hsa04660 | T cell receptor signaling pathway | 6.653E-04 | 2.238E-03 | IKBKB, RELA, NFKB1 |
09150 Organismal Systems | 09151 Immune system | hsa04620 | Toll-like receptor signaling pathway | 7.033E-04 | 2.296E-03 | IKBKB, RELA, NFKB1 |
09130 Environmental Information Processing | 09132 Signal transduction | hsa04064 | NF-kappa B signaling pathway | 4.800E-04 | 1.773E-03 | IKBKB, RELA, NFKB1 |
09160 Human Diseases | 09167 Infectious diseases | hsa05142 | Chagas disease (American trypanosomiasis) | 6.653E-04 | 2.238E-03 | IKBKB, RELA, NFKB1 |
09130 Environmental Information Processing | 09132 Signal transduction | hsa04668 | TNF signaling pathway | 7.832E-04 | 2.415E-03 | IKBKB, RELA, NFKB1 |
09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04931 | Insulin resistance | 7.627E-04 | 2.415E-03 | IKBKB, RELA, NFKB1 |
09160 Human Diseases | 09167 Infectious diseases | hsa05145 | Toxoplasmosis | 9.600E-04 | 2.880E-03 | IKBKB, RELA, NFKB1 |
09160 Human Diseases | 09161 Cancers | hsa05206 | MicroRNAs in cancer | 1.389E-03 | 3.760E-03 | IKBKB, TP53, NFKB1, MCL1 |
09150 Organismal Systems | 09158 Development | hsa04380 | Osteoclast differentiation | 1.327E-03 | 3.746E-03 | IKBKB, RELA, NFKB1 |
09130 Environmental Information Processing | 09132 Signal transduction | hsa04071 | Sphingolipid signaling pathway | 1.008E-03 | 2.944E-03 | TP53, RELA, NFKB1 |
09160 Human Diseases | 09167 Infectious diseases | hsa05162 | Measles | 1.445E-03 | 3.820E-03 | TP53, RELA, NFKB1 |
09160 Human Diseases | 09167 Infectious diseases | hsa05164 | Influenza A | 2.962E-03 | 7.307E-03 | IKBKB, RELA, NFKB1 |
09150 Organismal Systems | 09151 Immune system | hsa04062 | Chemokine signaling pathway | 3.570E-03 | 8.432E-03 | IKBKB, RELA, NFKB1 |
09160 Human Diseases | 09161 Cancers | hsa05202 | Transcriptional misregulation in cancer | 3.207E-03 | 7.739E-03 | TP53, RELA, NFKB1 |
09160 Human Diseases | 09167 Infectious diseases | hsa05134 | Legionellosis | 3.712E-03 | 8.584E-03 | RELA, NFKB1 |
09160 Human Diseases | 09164 Substance dependence | hsa05030 | Cocaine addiction | 2.958E-03 | 7.307E-03 | RELA, NFKB1 |
09160 Human Diseases | 09161 Cancers | hsa05219 | Bladder cancer | 2.079E-03 | 5.368E-03 | DAPK1, TP53 |
09120 Genetic Information Processing | 09124 Replication and repair | hsa03410 | Base excision repair | 1.350E-03 | 3.746E-03 | POLB, APEX1 |
ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
---|---|---|---|
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities | Genetic disease | Q00-Q99 | ALPL; |
C00-D49: Neoplasms | Cancer | C00-C96 | NFKB1; MCL1; |
C00-D49: Neoplasms | Colon cancer | C50 | ALPL; |
E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | NFKB1; |
A00-B99: Certain infectious and parasitic diseases | Anthelmintic | B89 | ALPL; |