Plant Name: Ferula fukanensis
Taxonomic Information:
Plant ID: NPO3780
Plant Latin Name: Ferula fukanensis
Taxonomy Genus: Ferula
Taxonomy Family: Apiaceae
Plant External Links:
NCBI TaxonomyDB:
1271630
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TSHR; | |
| TP53; | |
| SMN1;SMN2; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Methyl-lysine/arginine binding protein | SMN1;SMN2 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Transcription Factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:0038194; thyroid-stimulating hormone signaling pathway | 3.106E-04 | 9.356E-01 | TSHR |
| BP | GO:0050896; response to stimulus | GO:1901653; cellular response to peptide | 3.438E-04 | 9.356E-01 | TP53, TSHR |
| MF | GO:0060089; molecular transducer activity | GO:0004996; thyroid-stimulating hormone receptor activity | 3.106E-04 | 9.356E-01 | TSHR |
| BP | GO:0065007; biological regulation | GO:0090559; regulation of membrane permeability | 1.314E-02 | 1.000E+00 | TP53 |
| BP | GO:0008283; cell proliferation | GO:0048145; regulation of fibroblast proliferation | 1.330E-02 | 1.000E+00 | TP53 |
| BP | GO:0009987; cellular process | GO:0035690; cellular response to drug | 4.316E-02 | 1.000E+00 | TP53 |
| CC | GO:0016020; membrane | GO:0016323; basolateral plasma membrane | 2.861E-02 | 1.000E+00 | TSHR |
| CC | GO:0032991; macromolecular complex | GO:0043235; receptor complex | 4.918E-02 | 1.000E+00 | TSHR |
| MF | GO:0005488; binding | GO:0019903; protein phosphatase binding | 1.822E-02 | 1.000E+00 | TP53 |
| MF | GO:0060089; molecular transducer activity | GO:0008528; G-protein coupled peptide receptor activity | 2.021E-02 | 1.000E+00 | TSHR |
| MF | GO:0005488; binding | GO:0001047; core promoter binding | 2.587E-02 | 1.000E+00 | TP53 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09160 Human Diseases | 09161 Cancers | hsa05223 | Non-small cell lung cancer | 8.377E-03 | 2.796E-02 | TP53 |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05014 | Amyotrophic lateral sclerosis (ALS) | 7.631E-03 | 2.796E-02 | TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05217 | Basal cell carcinoma | 8.228E-03 | 2.796E-02 | TP53 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04923 | Regulation of lipolysis in adipocytes | 8.377E-03 | 2.796E-02 | TSHR |
| 09160 Human Diseases | 09161 Cancers | hsa05210 | Colorectal cancer | 9.272E-03 | 2.796E-02 | TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05212 | Pancreatic cancer | 9.868E-03 | 2.796E-02 | TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05230 | Central carbon metabolism in cancer | 1.002E-02 | 2.796E-02 | TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05220 | Chronic myeloid leukemia | 1.091E-02 | 2.796E-02 | TP53 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04918 | Thyroid hormone synthesis | 1.061E-02 | 2.796E-02 | TSHR |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04115 | p53 signaling pathway | 1.031E-02 | 2.796E-02 | TP53 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Cancer | C00-C96 | TP53; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Toxicity | T36-T50, T51-T65 | TP53; |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | TP53; |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | TP53; |
| H60-H95: Diseases of the ear and mastoid process | Hearing disorder | H90.5 | TP53; |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TP53; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | TP53; |
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | TP53; |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | TP53; |
| I00-I99: Diseases of the circulatory system | Renal artery disease | I70.1 | TP53; |
| C00-D49: Neoplasms | Oral cavity cancer | C00-C08 | TP53; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
