CMAUP Plant Collective Molecular Activities

Plant Name: Pyrus communis

Taxonomic Information:

Plant ID: NPO366
Plant Latin Name: Pyrus communis
Taxonomy Genus: Pyrus
Taxonomy Family: Rosaceae

Plant External Links:

NCBI TaxonomyDB: 23211
Plant-of-the-World-Online: 30065762-2

Used in Medicines:

Country/Region:

Turkey; Italy; India

Traditional Medicine System:

Medicinal Functions:

Astringent; Febrifuge; Sedative

Geographical Distribution:

Canada; Turkey; Italy; Turkmenistan; France; Georgia; Ireland; Ecuador; Uzbekistan; Australia; Germany; Belgium; Iraq; Kazakhstan; Spain; Ukraine; Netherlands; Denmark; Poland; United States; Sweden; Belarus; Switzerland; Russia; Romania; Albania; South Africa; Tajikistan; India; United Kingdom; Austria; Greece; Hungary; Cyprus

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0032501; multicellular organismal process	GO:0055015; ventricular cardiac muscle cell development	5.177E-04	1.000E+00	LMNA
BP	GO:0009987; cellular process	GO:0090201; negative regulation of release of cytochrome c from mitochondria	8.801E-04	1.000E+00	LMNA
BP	GO:0009987; cellular process	GO:0007077; mitotic nuclear envelope disassembly	2.278E-03	1.000E+00	LMNA
BP	GO:0009987; cellular process	GO:2001237; negative regulation of extrinsic apoptotic signaling pathway	5.332E-03	1.000E+00	LMNA
BP	GO:0009987; cellular process	GO:0071456; cellular response to hypoxia	5.384E-03	1.000E+00	LMNA
BP	GO:0051179; localization	GO:1900180; regulation of protein localization to nucleus	1.144E-02	1.000E+00	LMNA
BP	GO:0040011; locomotion	GO:0030334; regulation of cell migration	4.007E-02	1.000E+00	LMNA
CC	GO:0043226; organelle	GO:0016607; nuclear speck	1.910E-02	1.000E+00	LMNA
CC	GO:0044421; extracellular region part	GO:0031012; extracellular matrix	2.661E-02	1.000E+00	LMNA

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09165 Cardiovascular diseases	hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	3.700E-03	6.000E-03	LMNA
09160 Human Diseases	09165 Cardiovascular diseases	hsa05410	Hypertrophic cardiomyopathy (HCM)	4.150E-03	6.000E-03	LMNA
09160 Human Diseases	09165 Cardiovascular diseases	hsa05414	Dilated cardiomyopathy	4.500E-03	6.000E-03	LMNA
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	7.000E-03	7.000E-03	LMNA

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases