Plant Name: Solanum aethiopicum
Taxonomic Information:
Plant ID: NPO3628
Plant Latin Name: Solanum aethiopicum
Taxonomy Genus: Solanum
Taxonomy Family: Solanaceae
Plant External Links:
NCBI TaxonomyDB:
205524
Plant-of-the-World-Online:
n.a.
Example Image
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| SLC superfamily of solute carriers | SLC5A1 | Sodium/glucose cotransporter 1 | P13866 | CHEMBL4979 |
| SLC superfamily of solute carriers | SLC5A2 | Sodium/glucose cotransporter 2 | P31639 | CHEMBL3884 |
| SLC superfamily of solute carriers | SLC5A4 | Low affinity sodium-glucose cotransporter | Q9NY91 | CHEMBL1770047 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0005215; transporter activity | GO:0005412; glucose:sodium symporter activity | 1.665E-11 | 3.626E-07 | SLC5A1, SLC5A2, SLC5A4 |
| BP | Unclassified; | GO:0035428; hexose transmembrane transport | 1.282E-09 | 4.654E-06 | SLC5A1, SLC5A2, SLC5A4 |
| BP | GO:0051179; localization | GO:1904659; glucose transmembrane transport | 1.282E-09 | 4.654E-06 | SLC5A1, SLC5A2, SLC5A4 |
| BP | Unclassified; | GO:0015758; glucose transport | 1.264E-08 | 2.502E-05 | SLC5A1, SLC5A2, SLC5A4 |
| BP | GO:0051179; localization | GO:0006814; sodium ion transport | 5.268E-07 | 6.038E-04 | SLC5A1, SLC5A2, SLC5A4 |
| CC | GO:0044425; membrane part | GO:0005887; integral component of plasma membrane | 3.874E-04 | 2.343E-01 | SLC5A1, SLC5A2, SLC5A4 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09154 Digestive system | hsa04973 | Carbohydrate digestion and absorption | 6.735E-03 | 1.061E-02 | SLC5A1 |
| 09150 Organismal Systems | 09154 Digestive system | hsa04978 | Mineral absorption | 7.631E-03 | 1.061E-02 | SLC5A1 |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 1.061E-02 | 1.061E-02 | SLC5A1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | SLC5A4; SLC5A1; SLC5A2; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | SLC5A4; SLC5A1; SLC5A2; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 1 diabetes | E10 | SLC5A2; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 1/2 diabetes | E08-E13 | SLC5A4; |
| K00-K95: Diseases of the digestive system | Liver disease | K70-K77 | SLC5A2; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
