CMAUP Plant Collective Molecular Activities

Plant Name: Rheum maximowiczii

Taxonomic Information:

Plant ID: NPO3599
Plant Latin Name: Rheum maximowiczii
Taxonomy Genus: Rheum
Taxonomy Family: Polygonaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Uzbekistan

Traditional Medicine System:

Geographical Distribution:

Uzbekistan

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	HCAR2;
Enzyme_unclassified	TDP1; RECQL; HSD17B10; HPGD; ALDH1A1;
Protein Kinase	FYN; EGFR;
Lyase	CA2; CA1; CA6;
ATP-binding cassette	ABCB1;
Methyl-lysine/arginine binding protein	L3MBTL1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
ATP-binding cassette	ABCB1	P-glycoprotein 1	P08183	CHEMBL4302
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Methyl-lysine/arginine binding protein	L3MBTL1	Lethal(3)malignant brain tumor-like protein 1	Q9Y468	CHEMBL1287622
Protein Kinase	FYN	Tyrosine-protein kinase FYN	P06241	CHEMBL1841
Protein Kinase	EGFR	Epidermal growth factor receptor erbB1	P00533	CHEMBL203
Small molecule receptor (family A GPCR)	HCAR2	Hydroxycarboxylic acid receptor 2	Q8TDS4	CHEMBL3785

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.078E-07	2.348E-03	CA1, CA2, CA6
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.679E-06	1.828E-02	CA1, CA2, CA6
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	3.104E-06	2.253E-02	CA1, CA2, CA6
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	6.262E-06	2.727E-02	CA1, CA2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.451E-07	8.417E-06	CA1, CA2, CA6
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	1.026E-03	1.984E-02	FYN, EGFR
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	9.450E-04	1.984E-02	ABCB1, CA2
09130 Environmental Information Processing	09132 Signal transduction	hsa04072	Phospholipase D signaling pathway	3.812E-03	5.527E-02	FYN, EGFR
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04510	Focal adhesion	7.358E-03	8.536E-02	FYN, EGFR
09160 Human Diseases	09161 Cancers	hsa05213	Endometrial cancer	3.329E-02	1.092E-01	EGFR
09160 Human Diseases	09161 Cancers	hsa05223	Non-small cell lung cancer	3.581E-02	1.092E-01	EGFR
Unclassified	Unclassified	hsa04320	Dorso-ventral axis formation	1.741E-02	1.092E-01	EGFR
09160 Human Diseases	09161 Cancers	hsa05214	Glioma	4.145E-02	1.092E-01	EGFR
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	4.207E-02	1.092E-01	EGFR

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
NA: NA	Edema	NA	CA2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases