Plant ID: NPO3597
Plant Latin Name: Rheedia acuminata
Taxonomy Genus: Rheedia
Taxonomy Family: Clusiaceae
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
ADORA3; ADORA2A; ADORA1; | |
TSHR; | |
ACHE; | |
FLT3; | |
ADK; CBR1; AKR1B1; AKR1B10; NOX4; | |
CA2; CA12; CA14; CA7; CA4; | |
MMP9; MMP1; MMP12; MMP2; | |
HIF1A; NFKB1; | |
SLCO1B3; SLCO1B1; | |
XDH; | |
APP; |
Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|
Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
Enzyme_unclassified | ADK | Adenosine kinase | P55263 | CHEMBL3589 |
Enzyme_unclassified | CBR1 | Carbonyl reductase [NADPH] 1 | P16152 | CHEMBL5586 |
Enzyme_unclassified | AKR1B1 | Aldose reductase | P15121 | CHEMBL1900 |
Enzyme_unclassified | AKR1B10 | Aldo-keto reductase family 1 member B10 | O60218 | CHEMBL5983 |
Enzyme_unclassified | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
Lyase | CA4 | Carbonic anhydrase IV | P22748 | CHEMBL3729 |
Metallo protease | MMP9 | Matrix metalloproteinase 9 | P14780 | CHEMBL321 |
Metallo protease | MMP1 | Matrix metalloproteinase-1 | P03956 | CHEMBL332 |
Metallo protease | MMP12 | Matrix metalloproteinase 12 | P39900 | CHEMBL4393 |
Metallo protease | MMP2 | Matrix metalloproteinase-2 | P08253 | CHEMBL333 |
Oxidoreductase | XDH | Xanthine dehydrogenase | P47989 | CHEMBL1929 |
Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
Protein Kinase | FLT3 | Tyrosine-protein kinase receptor FLT3 | P36888 | CHEMBL1974 |
SLC superfamily of solute carriers | SLCO1B3 | Solute carrier organic anion transporter family member 1B3 | Q9NPD5 | CHEMBL1743121 |
SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
Small molecule receptor (family A GPCR) | ADORA3 | Adenosine A3 receptor | P0DMS8 | CHEMBL256 |
Small molecule receptor (family A GPCR) | ADORA2A | Adenosine A2a receptor | P29274 | CHEMBL251 |
Small molecule receptor (family A GPCR) | ADORA1 | Adenosine A1 receptor | P30542 | CHEMBL226 |
Transcription Factor | HIF1A | Hypoxia-inducible factor 1 alpha | Q16665 | CHEMBL4261 |
Transcription Factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
Unclassified | APP | Beta amyloid A4 protein | P05067 | CHEMBL2487 |
GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|
MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 2.253E-11 | 1.635E-07 | CA12, CA14, CA2, CA4, CA7 |
MF | GO:0005488; binding | GO:0019825; oxygen binding | 7.967E-11 | 4.337E-07 | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, NOX4 |
BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 1.132E-09 | 4.929E-06 | CYP1A1, CYP1A2, CYP1B1, CYP2C19 |
BP | GO:0008152; metabolic process | GO:0008202; steroid metabolic process | 3.906E-09 | 1.241E-05 | AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19 |
BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 7.886E-09 | 1.717E-05 | CA12, CA14, CA2, CA4, CA7 |
BP | GO:0008152; metabolic process | GO:0019373; epoxygenase P450 pathway | 3.186E-08 | 4.956E-05 | CYP1A1, CYP1A2, CYP1B1, CYP2C19 |
MF | GO:0003824; catalytic activity | GO:0070330; aromatase activity | 4.704E-08 | 6.583E-05 | CYP19A1, CYP1A1, CYP1A2, CYP1B1 |
MF | GO:0005488; binding | GO:0020037; heme binding | 4.837E-08 | 6.583E-05 | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, NOX4 |
BP | GO:0008152; metabolic process | GO:0017144; drug metabolic process | 9.387E-08 | 1.022E-04 | ACHE, ADK, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2C19 |
MF | GO:0060089; molecular transducer activity | GO:0001609; G-protein coupled adenosine receptor activity | 1.304E-07 | 1.235E-04 | ADORA1, ADORA2A, ADORA3 |
MF | GO:0005488; binding | GO:0005506; iron ion binding | 1.824E-07 | 1.584E-04 | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, XDH |
BP | Unclassified; | GO:0044259; multicellular organismal macromolecule metabolic process | 2.412E-07 | 1.946E-04 | HIF1A, MMP1, MMP12, MMP2, MMP9 |
BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 3.084E-07 | 2.345E-04 | CA12, CA2, CA4, CA7 |
BP | GO:0009987; cellular process | GO:0001973; adenosine receptor signaling pathway | 3.123E-07 | 2.345E-04 | ADORA1, ADORA2A, ADORA3 |
CC | GO:0016020; membrane | GO:0016323; basolateral plasma membrane | 4.432E-07 | 3.016E-04 | ADORA1, CA2, CA4, SLCO1B1, SLCO1B3, TSHR |
BP | Unclassified; | GO:0044236; multicellular organism metabolic process | 6.864E-07 | 4.152E-04 | HIF1A, MMP1, MMP12, MMP2, MMP9 |
MF | GO:0003824; catalytic activity | GO:0009055; electron transfer activity | 7.533E-07 | 4.273E-04 | AKR1B1, CYP19A1, CYP1A2, NOX4, XDH |
BP | GO:0023052; signaling | GO:0032230; positive regulation of synaptic transmission, GABAergic | 1.059E-06 | 5.624E-04 | ADORA2A, CA2, CA7 |
BP | GO:0009987; cellular process | GO:0009967; positive regulation of signal transduction | 1.829E-06 | 8.474E-04 | ADORA1, ADORA2A, AKR1B1, APP, CYP1B1, FLT3, HIF1A, MMP12, MMP9, NFKB1, NOX4, XDH |
BP | GO:0008152; metabolic process | GO:0030574; collagen catabolic process | 3.431E-06 | 1.465E-03 | MMP1, MMP12, MMP2, MMP9 |
BP | GO:0008152; metabolic process | GO:0022900; electron transport chain | 5.556E-06 | 2.086E-03 | AKR1B1, CYP19A1, CYP1A2, NOX4, XDH |
BP | GO:0008152; metabolic process | GO:0009404; toxin metabolic process | 6.486E-06 | 2.366E-03 | CYP1A1, CYP1A2, CYP1B1 |
BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 7.471E-06 | 2.366E-03 | CA2, CA7 |
BP | GO:0009987; cellular process | GO:0022617; extracellular matrix disassembly | 7.497E-06 | 2.366E-03 | MMP1, MMP12, MMP2, MMP9 |
CC | GO:0044464; cell part | GO:0099056; integral component of presynaptic membrane | 7.471E-06 | 2.366E-03 | ADORA1, ADORA2A |
BP | GO:0050896; response to stimulus | GO:0010038; response to metal ion | 1.006E-05 | 2.897E-03 | APP, CA2, CYP1A1, CYP1A2, HIF1A, MMP9 |
BP | GO:0008152; metabolic process | GO:0018894; dibenzo-p-dioxin metabolic process | 1.493E-05 | 3.869E-03 | CYP1A1, CYP1A2 |
BP | GO:0009987; cellular process | GO:0071407; cellular response to organic cyclic compound | 1.730E-05 | 4.281E-03 | APP, CYP1A1, CYP1B1, FLT3, NFKB1, NOX4 |
MF | GO:0003824; catalytic activity | GO:0008395; steroid hydroxylase activity | 2.165E-05 | 4.861E-03 | CYP19A1, CYP1A1, CYP2C19 |
BP | GO:0040011; locomotion | GO:0030334; regulation of cell migration | 2.226E-05 | 4.947E-03 | ADORA1, ADORA3, APP, CYP19A1, CYP1B1, HIF1A, MMP9, NOX4 |
MF | GO:0005488; binding | GO:0008270; zinc ion binding | 3.168E-05 | 6.829E-03 | CA12, CA2, CA4, CA7, MMP1, MMP12, MMP2, MMP9 |
BP | GO:0050896; response to stimulus | GO:0050728; negative regulation of inflammatory response | 3.313E-05 | 6.937E-03 | ADORA1, ADORA2A, CYP19A1, NFKB1 |
MF | GO:0003824; catalytic activity | GO:0004222; metalloendopeptidase activity | 3.313E-05 | 6.937E-03 | MMP1, MMP12, MMP2, MMP9 |
BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 3.724E-05 | 7.509E-03 | CYP1A2, CYP2C19 |
MF | GO:0003824; catalytic activity | GO:0016903; oxidoreductase activity, acting on the aldehyde or oxo group of donors | 4.741E-05 | 9.217E-03 | AKR1B1, AKR1B10, XDH |
BP | GO:0051179; localization | GO:0002793; positive regulation of peptide secretion | 4.947E-05 | 9.533E-03 | ACHE, ADORA1, ADORA2A, HIF1A, MMP12 |
BP | GO:0050896; response to stimulus | GO:0001666; response to hypoxia | 5.327E-05 | 1.000E-02 | ADORA1, CYP1A1, HIF1A, MMP2, NOX4 |
Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|---|
09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 3.894E-11 | 4.127E-09 | CA12, CA2, CA4, CA7, CA14 |
09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 1.600E-07 | 8.480E-06 | CBR1, CYP1A2, CYP1A1, CYP1B1, CYP2C19 |
09100 Metabolism | 09103 Lipid metabolism | hsa00140 | Steroid hormone biosynthesis | 1.890E-06 | 6.676E-05 | CYP1A2, CYP1A1, CYP1B1, CYP19A1 |
09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 4.769E-06 | 1.264E-04 | CBR1, CYP1A2, CYP1A1, CYP1B1 |
09160 Human Diseases | 09161 Cancers | hsa05200 | Pathways in cancer | 2.849E-05 | 4.576E-04 | FLT3, MMP1, MMP2, HIF1A, MMP9, NFKB1 |
09100 Metabolism | 09105 Amino acid metabolism | hsa00380 | Tryptophan metabolism | 3.204E-05 | 4.576E-04 | CYP1A2, CYP1A1, CYP1B1 |
Unclassified | Unclassified | hsa01100 | Metabolic pathways | 7.588E-05 | 8.043E-04 | CBR1, AKR1B10, CYP1A2, CYP1A1, ADK, AKR1B1, CYP2C19, CYP19A1, XDH |
09150 Organismal Systems | 09152 Endocrine system | hsa04913 | Ovarian steroidogenesis | 6.290E-05 | 7.409E-04 | CYP1A1, CYP1B1, CYP19A1 |
09160 Human Diseases | 09161 Cancers | hsa05219 | Bladder cancer | 3.454E-05 | 4.576E-04 | MMP1, MMP2, MMP9 |
09130 Environmental Information Processing | 09132 Signal transduction | hsa04024 | cAMP signaling pathway | 2.424E-04 | 2.141E-03 | ADORA2A, ADORA1, NFKB1, TSHR |
09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 1.794E-04 | 1.729E-03 | SLCO1B1, CA2, SLCO1B3 |
09130 Environmental Information Processing | 09133 Signaling molecules and interaction | hsa04080 | Neuroactive ligand-receptor interaction | 8.438E-04 | 5.963E-03 | ADORA2A, ADORA3, ADORA1, TSHR |
09130 Environmental Information Processing | 09132 Signal transduction | hsa04071 | Sphingolipid signaling pathway | 8.376E-04 | 5.963E-03 | ADORA3, ADORA1, NFKB1 |
09150 Organismal Systems | 09155 Excretory system | hsa04964 | Proximal tubule bicarbonate reclamation | 5.764E-04 | 4.700E-03 | CA2, CA4 |
09100 Metabolism | 09110 Biosynthesis of other secondary metabolites | hsa00232 | Caffeine metabolism | 2.318E-05 | 4.576E-04 | CYP1A2, XDH |
09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 9.197E-04 | 6.093E-03 | CYP1A2, CYP2C19 |
09100 Metabolism | 09101 Carbohydrate metabolism | hsa00052 | Galactose metabolism | 9.844E-04 | 6.138E-03 | AKR1B10, AKR1B1 |
09100 Metabolism | 09101 Carbohydrate metabolism | hsa00040 | Pentose and glucuronate interconversions | 1.417E-03 | 7.908E-03 | AKR1B10, AKR1B1 |
09100 Metabolism | 09101 Carbohydrate metabolism | hsa00051 | Fructose and mannose metabolism | 1.120E-03 | 6.597E-03 | AKR1B10, AKR1B1 |
ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
---|---|---|---|
A00-B99: Certain infectious and parasitic diseases | Sepsis | A40, A41 | ADORA1; |
NA: NA | Edema | NA | CA2; |
I00-I99: Diseases of the circulatory system | Edema associated with congestive heart failure | I50, R60.9 | CA2; |
G00-G99: Diseases of the nervous system G00-G99 | Encephalopathy | G93.4 | XDH; |
N00-N99: Diseases of the genitourinary system | Endometriosis | N80 | CYP19A1; |
S00-T88: Injury, poisoning and certain other consequences of external causes | Brain injury | S09.90 | APP; |
C00-D49: Neoplasms | Breast cancer | C50 | FLT3; CYP19A1; |
C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | AKR1B1; |
M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | AKR1B1; MMP1; |
K00-K95: Diseases of the digestive system | Duodenal ulcers | K25-K27 | CA2; |
NA: NA | Early satiation associated with functional dyspepsia | NA | ACHE; |
J00-J99: Diseases of the respiratory system | Chronic obstructive pulmonary disease | J40-J44, J47 | MMP12; ADORA2A; |
K00-K95: Diseases of the digestive system | Xerostomia | K11.7, R68.2 | ACHE; |
A00-B99: Certain infectious and parasitic diseases | Helminth infection | A00-B99 | ACHE; |
NA: NA | Hepatitis C virus infection | NA | ADORA3; |
NA: NA | Hematopoietic stem cell transplantation | NA | FLT3; |
C00-D49: Neoplasms | Renal cell carcinoma | NA | MMP2; |
N00-N99: Diseases of the genitourinary system | Renal failure | N17, N18, N19 | ADORA1; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cognitive disorders | F01-F07, F04, F05, R41.3 | ACHE; ADORA1; |
C00-D49: Neoplasms | CLL | NA | FLT3; |
I00-I99: Diseases of the circulatory system | Pulmonary arterial hypertension | I27.0, I27.2 | HIF1A; |
C00-D49: Neoplasms | Hormonally-responsive breast cancer | C50 | CYP19A1; |
I00-I99: Diseases of the circulatory system | High blood pressure | I10-I16 | CA2; |
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure | Radionuclide imaging | W88 | ADORA2A; |
C00-D49: Neoplasms | Colon cancer | C50 | FLT3; |
I00-I99: Diseases of the circulatory system | Orthostatic hypotension | I95.1 | ADORA1; |
I00-I99: Diseases of the circulatory system | Cerebrovascular ischaemia | I61-I63 | ADORA3; |
I00-I99: Diseases of the circulatory system | Cerebral amyloid angiopathy | I68.0 | APP; |
A00-B99: Certain infectious and parasitic diseases | Human immunodeficiency virus infection | B20-B26 | FLT3; |
H00-H59: Diseases of the eye and adnexa | Chronic glaucoma | H40-H42 | ACHE; |
E00-E89: Endocrine, nutritional and metabolic diseases | Hyperlipidaemia | E78 | ADORA1; |
I00-I99: Diseases of the circulatory system | Hypertension | I10-I16 | ADORA1; ADORA2A; |
E00-E89: Endocrine, nutritional and metabolic diseases | Hypertriglyceridemia | E78.1, E78.2, E78.3, I47-I49 | ADORA1; |
C00-D49: Neoplasms | Prostate cancer | C61 | FLT3; |
N00-N99: Diseases of the genitourinary system | Prostate disease | N42.9 | CYP19A1; |
I00-I99: Diseases of the circulatory system | Ischemia | I99.8 | ADORA3; |
E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | NFKB1; |
I00-I99: Diseases of the circulatory system | Heart failure | I50 | ADORA1; XDH; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | CA2; |
E00-E89: Endocrine, nutritional and metabolic diseases | Inflammation | E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89 | ADORA3; |
C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | MMP12; |
N00-N99: Diseases of the genitourinary system | Urinary dysfunction | N39.3-N39.4 | ACHE; |
K00-K95: Diseases of the digestive system | Ulcerative colitis | K51 | MMP9; |
NA: NA | Upper abdominal bloating | NA | ACHE; |
C00-D49: Neoplasms | Colorectal cancer | C18-C21 | FLT3; MMP9; |
C00-D49: Neoplasms | Lung cancer | C33-C34 | MMP2; |
H00-H59: Diseases of the eye and adnexa | Macular degeneration | H35.3 | APP; |
C00-D49: Neoplasms | Lymphoma | C81-C86 | HIF1A; |
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure | Diagnostic test to differentiate primary and secondary hypothyroidism | W88 | TSHR; |
I00-I99: Diseases of the circulatory system | Coronary disorder diagnosis | I20-I25 | ADORA2A; |
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Convulsions | R56.0 | ADK; |
C00-D49: Neoplasms | Leukemia | C90-C95 | FLT3; |
I00-I99: Diseases of the circulatory system | Neurological disease | I21, I22, R52, R52.1-R52.2, R60.9, G89 | APP; |
C00-D49: Neoplasms | Advanced breast cancer | C50 | CYP19A1; |
S00-T88: Injury, poisoning and certain other consequences of external causes | Poison intoxication | T36-T50 | ACHE; |
A00-B99: Certain infectious and parasitic diseases | Malaria | B54 | ADORA3; |
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Fatigue | R53 | ADORA1; |
J00-J99: Diseases of the respiratory system | Allergic rhinitis | J00, J30, J31.0, T78.4 | ADORA2A; |
S00-T88: Injury, poisoning and certain other consequences of external causes | Allergy | T78.4 | ADORA1; |
G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | ACHE; APP; |
C00-D49: Neoplasms | AML | NA | FLT3; |
E00-E89: Endocrine, nutritional and metabolic diseases | Hyperuricemia | E79.0 | XDH; |
E00-E89: Endocrine, nutritional and metabolic diseases | Hyperuricaemia in gout | E79.0, M10 | XDH; |
G00-G99: Diseases of the nervous system G00-G99 | Mild to moderate alzheimer disease | G30 | APP; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Mild cognitive impairment | F06.7 | ACHE; APP; |
J00-J99: Diseases of the respiratory system | Airway inflammation | J00-J99 | FLT3; |
H00-H59: Diseases of the eye and adnexa | Age related macular degeneration | H35.3 | APP; |
C00-D49: Neoplasms | Ovarian cancer | C56 | MMP2; |
C00-D49: Neoplasms | Hepatocellular carcinoma | C22.0 | ADORA3; |
I00-I99: Diseases of the circulatory system | Acute and chronic heart failure | I50 | ADORA1; |
L00-L99: Diseases of the skin and subcutaneous tissue | Acne vulgaris | L70.0 | MMP2; |
I00-I99: Diseases of the circulatory system | Aortic aneurysm | I71 | MMP12; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | ACHE; |
L00-L99: Diseases of the skin and subcutaneous tissue | Psoriasis | L40 | FLT3; |
E00-E89: Endocrine, nutritional and metabolic diseases | Atrial fibrillation | E78, I48 | ADORA1; |
G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | ACHE; ADORA2A; ADK; |
C00-D49: Neoplasms | Pancreatic cancer | C25 | FLT3; MMP2; |
G00-G99: Diseases of the nervous system G00-G99 | Parkinson's disease | G20 | ACHE; ADORA1; ADORA2A; |
A00-B99: Certain infectious and parasitic diseases | Pediculus humanus capitis | B85.0 | ACHE; |
I00-I99: Diseases of the circulatory system | Stroke | I61-I63, I80-I82 | MMP9; |
G00-G99: Diseases of the nervous system G00-G99 | Multiple scierosis | G35 | ADORA1; |
C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR; |
E00-E89: Endocrine, nutritional and metabolic diseases | Amyloidosis | E85 | APP; |
NA: NA | Anaplastic mixed oligoastrocytoma | NA | FLT3; |
H00-H59: Diseases of the eye and adnexa | Ocular hypertension | H40.0 | CA4; |
H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | CA4; ACHE; CA2; |
H00-H59: Diseases of the eye and adnexa | Glaucoma | H40-H42 | ACHE; ADORA1; ADORA2A; ADORA3; AKR1B1; |
E00-E89: Endocrine, nutritional and metabolic diseases | Autoimmune diabetes | E08-E13 | ADORA1; |
M00-M99: Diseases of the musculoskeletal system and connective tissue | Osteoarthritis | M15-M19, M47 | MMP2; |
C00-D49: Neoplasms | Acute lymphoblastic leukemia | C91.0 | FLT3; |
J00-J99: Diseases of the respiratory system | Asthma | J45 | MMP12; CBR1; ADORA1; ADORA2A; |
M00-M99: Diseases of the musculoskeletal system and connective tissue | Arthritis | M00-M25 | MMP1; |
I00-I99: Diseases of the circulatory system | Arteriosclerosis | I70 | ADORA2A; |
I00-I99: Diseases of the circulatory system | Atherosclerosis | I70 | MMP12; |
C00-D49: Neoplasms | Glioma | C71 | APP; |
G00-G99: Diseases of the nervous system G00-G99 | Neurodegenerative disease | G30-G32 | ACHE; |
G00-G99: Diseases of the nervous system G00-G99 | Neuropathic pain | G64, G90.0 | ADORA1; ADORA2A; |
S00-T88: Injury, poisoning and certain other consequences of external causes | Poisoning due to pesticides and chemicals | T36-T50 | ACHE; |
E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic cataract | E10.36, E11.36 | AKR1B1; |
E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic complication | E08-E13 | AKR1B1; |
L00-L99: Diseases of the skin and subcutaneous tissue | Diabetic foot ulcer | L88-L89 | ADORA2A; |
E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic nephropathy | E11.21 | MMP1; |
E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic neuropathy | E11.40 | AKR1B1; |
G00-G99: Diseases of the nervous system G00-G99 | Diagnostic imaging | G30, I73.9 | APP; |
C00-D49: Neoplasms | Non-small-cell lung cancer | NA | MMP2; |
E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | ADORA1; AKR1B1; |
G00-G99: Diseases of the nervous system G00-G99 | Myasthenia gravis diagnosis | G70.0 | ACHE; |
G00-G99: Diseases of the nervous system G00-G99 | Myasthenia gravis | G70.0 | ACHE; |
C00-D49: Neoplasms | Myeloid leukemia | C92 | FLT3; |
C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR; |
C00-D49: Neoplasms | Cancer | C00-C96 | NFKB1; FLT3; ACHE; HIF1A; ADORA3; MMP9; MMP2; APP; |
C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | FLT3; |
C00-D49: Neoplasms | Solid tumours | C00-D48 | FLT3; HIF1A; MMP9; MMP2; |
I00-I99: Diseases of the circulatory system | Cardiac arrhythmias | I47-I49 | ADORA1; |
I00-I99: Diseases of the circulatory system | Cardiac disease | I00-I99 | ADORA1; |
NA: NA | Geographic retinal atrophy | NA | APP; |
NA: NA | GIST | NA | FLT3; |
C00-D49: Neoplasms | Glioblastoma | NA | FLT3; |
C00-D49: Neoplasms | Gliosarcoma | NA | FLT3; |
M00-M99: Diseases of the musculoskeletal system and connective tissue | Gout | M10 | AKR1B1; XDH; |
G00-G99: Diseases of the nervous system G00-G99 | Epilepsy | G40 | ADK; |
G00-G99: Diseases of the nervous system G00-G99 | Epileptic seizures | G40, P90, R56 | ACHE; ADK; |
C00-D49: Neoplasms | Bladder cancer | C67 | CYP19A1; |
C00-D49: Neoplasms | Myelofibrosis | C94.4, D47.4 | FLT3; |