CMAUP Plant Collective Molecular Activities

Plant Name: Sophora mollis

Taxonomic Information:

Plant ID: NPO3544
Plant Latin Name: Sophora mollis
Taxonomy Genus: Sophora
Taxonomy Family: Fabaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

India

Traditional Medicine System:

Indian Folk

Geographical Distribution:

India

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Lyase	CA7; CA12; CA9;
Enzyme_unclassified	GFER; ALDH1A1; HSD17B10; AKR1B1; TNKS; TNKS2; PARP1;
Oxidoreductase	ALOX5; XDH;
Cysteine protease	CASP7; CASP1;
Unclassified	PFKFB3; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4; CYP1A2; CYP2C19; CYP2C9;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cysteine protease	CASP7	Caspase-7	P55210	CHEMBL3468
Cysteine protease	CASP1	Caspase-1	P29466	CHEMBL4801
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	TNKS	Tankyrase-1	O95271	CHEMBL6164
Enzyme_unclassified	TNKS2	Tankyrase-2	Q9H2K2	CHEMBL6154
Enzyme_unclassified	PARP1	Poly [ADP-ribose] polymerase-1	P09874	CHEMBL3105
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Oxidoreductase	ALOX5	Arachidonate 5-lipoxygenase	P09917	CHEMBL215
Oxidoreductase	XDH	Xanthine dehydrogenase	P47989	CHEMBL1929
Unclassified	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q16875	CHEMBL2331053
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.252E-11	2.725E-07	CYP1A2, CYP2C19, CYP2C9, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	4.114E-10	2.240E-06	CYP1A2, CYP2C19, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	3.794E-09	9.180E-06	CYP1A2, CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0005506; iron ion binding	1.035E-08	2.049E-05	ALOX5, CYP1A2, CYP2C19, CYP2C9, CYP3A4, XDH
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.134E-07	1.759E-04	CYP1A2, CYP2C19, CYP2C9
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.212E-07	1.759E-04	CYP1A2, CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	2.076E-07	2.659E-04	CYP1A2, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0006000; fructose metabolic process	4.285E-07	4.911E-04	AKR1B1, ALDH1A1, PFKFB3
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	4.285E-07	4.911E-04	CA12, CA7, CA9
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.248E-06	1.294E-03	CYP1A2, CYP2C19, CYP2C9
MF	GO:0003824; catalytic activity	GO:0003950; NAD+ ADP-ribosyltransferase activity	2.431E-06	2.272E-03	PARP1, TNKS, TNKS2
BP	GO:0065007; biological regulation	GO:1904357; negative regulation of telomere maintenance via telomere lengthening	2.733E-06	2.289E-03	PARP1, TNKS, TNKS2
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	4.351E-06	3.384E-03	AKR1B1, CYP1A2, CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	5.183E-06	3.762E-03	CYP1A2, CYP2C19, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	5.565E-06	3.909E-03	CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0070213; protein auto-ADP-ribosylation	6.104E-06	4.153E-03	TNKS, TNKS2
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	6.631E-06	4.247E-03	CA12, CA7, CA9
MF	GO:0005488; binding	GO:0020037; heme binding	8.209E-06	5.107E-03	CYP1A2, CYP2C19, CYP2C9, CYP3A4
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.224E-05	7.011E-03	CA12, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0016903; oxidoreductase activity, acting on the aldehyde or oxo group of donors	1.224E-05	7.011E-03	AKR1B1, ALDH1A1, XDH
BP	GO:0008152; metabolic process	GO:0070212; protein poly-ADP-ribosylation	1.524E-05	8.296E-03	PARP1, TNKS
CC	GO:0044464; cell part	GO:0005635; nuclear envelope	2.131E-05	1.055E-02	ALOX5, LMNA, PARP1, TNKS2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.699E-08	6.967E-07	CYP2C9, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4.733E-07	6.179E-06	CYP2C9, CYP1A2, ALDH1A1, CYP3A4
Unclassified	Unclassified	hsa01100	Metabolic pathways	1.176E-06	8.265E-06	CYP2C9, ALOX5, CYP1A2, ALDH1A1, AKR1B1, CYP2C19, CYP3A4, HSD17B10, XDH
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	6.028E-07	6.179E-06	CYP2C9, CYP1A2, CYP3A4, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.210E-06	8.265E-06	CYP2C9, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	5.763E-07	6.179E-06	CA12, CA7, CA9
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	3.115E-05	1.596E-04	CYP2C9, ALOX5, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5.086E-05	2.317E-04	CYP2C9, CYP1A2, CYP3A4
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.818E-04	7.454E-04	CYP2C9, ALOX5, CYP2C19
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	3.507E-04	1.307E-03	CASP7, PARP1, LMNA
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	1.367E-03	4.002E-03	CASP7, CASP1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	9.577E-04	3.020E-03	CYP3A4, XDH
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.519E-03	4.151E-03	CYP1A2, CYP3A4
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	2.524E-03	6.466E-03	CASP7, CASP1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	4.628E-04	1.581E-03	PFKFB3, AKR1B1
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	9.483E-06	5.555E-05	CYP1A2, XDH

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic cataract	E10.36, E11.36	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic complication	E08-E13	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	AKR1B1;
C00-D49: Neoplasms	Cancer	C00-C96	CA9;
C00-D49: Neoplasms	Solid tumours	C00-D48	PFKFB3; CA9;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	AKR1B1;
C00-D49: Neoplasms	Breast cancer	C50	CA9;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	AKR1B1;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	AKR1B1;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
C00-D49: Neoplasms	Renal cancer	C64	CA9;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases