Plant ID: NPO3504
Plant Latin Name: Argemone mexicana
Taxonomy Genus: Argemone
Taxonomy Family: Papaveraceae
NCBI TaxonomyDB:
54796
Plant-of-the-World-Online:
n.a.
Alterative; Analgesic; Antispasmodic; Antitussive; Demulcent; Emetic; Expectorant; Hallucinogenic; Purgative; Sedative; Skin; Warts
Tanzania; India; Rwanda; China; Kenya; Nigeria
DRD1; | |
MTOR; HSD17B10; POLB; APEX1; | |
TP53; | |
HTT; F3; THPO; | |
SMN1;SMN2; |
Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|
Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
Cytochrome P450 family 2 | CYP2D6 | Cytochrome P450 2D6 | P10635 | CHEMBL289 |
Enzyme_unclassified | MTOR | Serine/threonine-protein kinase mTOR | P42345 | CHEMBL2842 |
Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
Enzyme_unclassified | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
Methyl-lysine/arginine binding protein | SMN1;SMN2 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
Small molecule receptor (family A GPCR) | DRD1 | Dopamine D1 receptor | P21728 | CHEMBL2056 |
Transcription Factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
Unclassified | HTT | Huntingtin | P42858 | CHEMBL5514 |
Unclassified | F3 | Coagulation factor III | P13726 | CHEMBL4081 |
Unclassified | THPO | Thrombopoietin | P40225 | CHEMBL1293256 |
GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|
BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 6.054E-09 | 1.318E-04 | CYP1A2, CYP2C19, CYP2D6 |
BP | GO:0009987; cellular process | GO:0006286; base-excision repair, base-free sugar-phosphate removal | 4.878E-07 | 5.311E-03 | APEX1, POLB |
MF | GO:0005488; binding | GO:0019825; oxygen binding | 4.224E-06 | 1.768E-02 | CYP1A2, CYP2C19, CYP2D6 |
BP | GO:0008152; metabolic process | GO:0009820; alkaloid metabolic process | 1.022E-05 | 2.473E-02 | CYP1A2, CYP2D6 |
MF | GO:0005488; binding | GO:0003684; damaged DNA binding | 1.413E-05 | 3.076E-02 | APEX1, POLB, TP53 |
BP | GO:0032502; developmental process | GO:0007568; aging | 1.816E-05 | 3.594E-02 | APEX1, MTOR, POLB, TP53 |
BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 2.188E-05 | 3.665E-02 | CYP1A2, CYP2C19 |
CC | GO:0043226; organelle | GO:0097504; Gemini of coiled bodies | 3.206E-05 | 4.364E-02 | SMN1, SMN2 |
MF | Unclassified; | GO:0003906; DNA-(apurinic or apyrimidinic site) lyase activity | 3.788E-05 | 4.451E-02 | APEX1, POLB |
MF | GO:0003824; catalytic activity | GO:0004497; monooxygenase activity | 4.033E-05 | 4.451E-02 | CYP1A2, CYP2C19, CYP2D6 |
CC | GO:0032991; macromolecular complex | GO:0032797; SMN complex | 3.788E-05 | 4.451E-02 | SMN1, SMN2 |
Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|---|
09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 1.392E-05 | 1.086E-03 | CYP2D6, CYP1A2, CYP2C19 |
09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 1.828E-04 | 6.170E-03 | CYP1A2, CYP2C19 |
09160 Human Diseases | 09161 Cancers | hsa05214 | Glioma | 9.229E-04 | 1.511E-02 | TP53, MTOR |
09120 Genetic Information Processing | 09124 Replication and repair | hsa03410 | Base excision repair | 2.373E-04 | 6.170E-03 | POLB, APEX1 |
09160 Human Diseases | 09161 Cancers | hsa05230 | Central carbon metabolism in cancer | 9.802E-04 | 1.511E-02 | TP53, MTOR |
09160 Human Diseases | 09161 Cancers | hsa05215 | Prostate cancer | 1.721E-03 | 1.661E-02 | TP53, MTOR |
09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 1.162E-03 | 1.511E-02 | CYP2D6, CYP1A2 |
09150 Organismal Systems | 09149 Aging | hsa04211 | Longevity regulating pathway - mammal | 1.917E-03 | 1.661E-02 | TP53, MTOR |
09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 1.464E-03 | 1.631E-02 | CYP1A2, CYP2C19 |
09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 2.707E-03 | 2.111E-02 | CYP2D6, CYP2C19 |
ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
---|---|---|---|
G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | DRD1; |
G00-G99: Diseases of the nervous system G00-G99 | Parkinson's disease | G20 | DRD1; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Dementia | F01-F07 | DRD1; |
I00-I99: Diseases of the circulatory system | Hypertension | I10-I16 | DRD1; |
E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | DRD1; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cocaine addiction | F14.2 | DRD1; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Substance dependence | F10-F19 | DRD1; |
C00-D49: Neoplasms | Pancreatic cancer | C25 | F3; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cognitive disorders | F01-F07, F04, F05, R41.3 | DRD1; |
G00-G99: Diseases of the nervous system G00-G99 | Migraine | G43 | CYP2D6; |
A00-B99: Certain infectious and parasitic diseases | Malaria | B54 | CYP2D6; |
J00-J99: Diseases of the respiratory system | Adult respiratory distress syndrome | J80 | F3; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Psychotic disorders | F20-F29 | DRD1; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Psychiatric disorder | F01-F99 | DRD1; |
I00-I99: Diseases of the circulatory system | Bleeding | I74, I80-I82 | F3; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | CYP2D6; |
O00-O9A: Pregnancy, childbirth and the puerperium | Excessive bleeding following childbirth and spontaneous or elective abortion | O04 | DRD1; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Schizophrenia | F20 | DRD1; |