Plant Name: Macaranga conifera
Taxonomic Information:
Plant ID: NPO3499
Plant Latin Name: Macaranga conifera
Taxonomy Genus: Macaranga
Taxonomy Family: Euphorbiaceae
Plant External Links:
NCBI TaxonomyDB:
109817
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| ABCG2; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: | CYP19A1; |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| ATP-binding cassette | ABCG2 | ATP-binding cassette sub-family G member 2 | Q9UNQ0 | CHEMBL5393 |
| Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0061370; testosterone biosynthetic process | 5.177E-04 | 1.000E+00 | CYP19A1 |
| BP | GO:0051179; localization | GO:0042908; xenobiotic transport | 1.035E-03 | 1.000E+00 | ABCG2 |
| BP | GO:0032501; multicellular organismal process | GO:0060736; prostate gland growth | 1.139E-03 | 1.000E+00 | CYP19A1 |
| BP | GO:0008152; metabolic process | GO:0006703; estrogen biosynthetic process | 1.346E-03 | 1.000E+00 | CYP19A1 |
| BP | GO:0008152; metabolic process | GO:0046415; urate metabolic process | 1.346E-03 | 1.000E+00 | ABCG2 |
| BP | GO:0032502; developmental process | GO:0060065; uterus development | 1.449E-03 | 1.000E+00 | CYP19A1 |
| BP | GO:0032501; multicellular organismal process | GO:0030540; female genitalia development | 1.656E-03 | 1.000E+00 | CYP19A1 |
| BP | GO:0032501; multicellular organismal process | GO:0008585; female gonad development | 1.966E-03 | 1.000E+00 | CYP19A1 |
| BP | GO:0032502; developmental process | GO:0030879; mammary gland development | 2.277E-03 | 1.000E+00 | CYP19A1 |
| BP | GO:0051179; localization | GO:0033344; cholesterol efflux | 2.484E-03 | 1.000E+00 | ABCG2 |
| BP | GO:0051179; localization | GO:0006855; drug transmembrane transport | 6.616E-03 | 1.000E+00 | ABCG2 |
| BP | GO:0008152; metabolic process | GO:0016125; sterol metabolic process | 1.321E-02 | 1.000E+00 | CYP19A1 |
| BP | GO:0008152; metabolic process | GO:0022900; electron transport chain | 1.670E-02 | 1.000E+00 | CYP19A1 |
| CC | GO:0032991; macromolecular complex | GO:0043235; receptor complex | 3.306E-02 | 1.000E+00 | ABCG2 |
| MF | GO:0005215; transporter activity | GO:0008559; xenobiotic transmembrane transporting ATPase activity | 7.247E-04 | 1.000E+00 | ABCG2 |
| MF | GO:0003824; catalytic activity | GO:0070330; aromatase activity | 2.380E-03 | 1.000E+00 | CYP19A1 |
| MF | GO:0003824; catalytic activity | GO:0008395; steroid hydroxylase activity | 3.517E-03 | 1.000E+00 | CYP19A1 |
| MF | GO:0005488; binding | GO:0019825; oxygen binding | 4.654E-03 | 1.000E+00 | CYP19A1 |
| MF | GO:0003824; catalytic activity | GO:0009055; electron transfer activity | 1.115E-02 | 1.000E+00 | CYP19A1 |
| MF | GO:0005488; binding | GO:0020037; heme binding | 1.321E-02 | 1.000E+00 | CYP19A1 |
| MF | GO:0005488; binding | GO:0005506; iron ion binding | 1.650E-02 | 1.000E+00 | CYP19A1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09152 Endocrine system | hsa04913 | Ovarian steroidogenesis | 4.994E-03 | 8.859E-03 | CYP19A1 |
| 09130 Environmental Information Processing | 09131 Membrane transport | hsa02010 | ABC transporters | 4.395E-03 | 8.859E-03 | ABCG2 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00140 | Steroid hormone biosynthesis | 5.792E-03 | 8.859E-03 | CYP19A1 |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 7.088E-03 | 8.859E-03 | ABCG2 |
| Unclassified | Unclassified | hsa01100 | Metabolic pathways | 1.201E-01 | 1.201E-01 | CYP19A1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| N00-N99: Diseases of the genitourinary system | Endometriosis | N80 | CYP19A1; |
| C00-D49: Neoplasms | Bladder cancer | C67 | CYP19A1; |
| C00-D49: Neoplasms | Hormonally-responsive breast cancer | C50 | CYP19A1; |
| C00-D49: Neoplasms | Advanced breast cancer | C50 | CYP19A1; |
| C00-D49: Neoplasms | Breast cancer | C50 | CYP19A1; |
| N00-N99: Diseases of the genitourinary system | Prostate disease | N42.9 | CYP19A1; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
