CMAUP Plant Collective Molecular Activities

Plant Name: Swietenia mahagoni

Taxonomic Information:

Plant ID: NPO3494
Plant Latin Name: Swietenia mahagoni
Taxonomy Genus: Swietenia
Taxonomy Family: Meliaceae

Plant External Links:

NCBI TaxonomyDB: 459165
Plant-of-the-World-Online: 1080203-2

Used in Medicines:

Country/Region:

Thailand

Traditional Medicine System:

Geographical Distribution:

Jamaica; United States; Bangladesh; Cuba; Venezuela; Bahamas; Trinidad and Tobago; Thailand; Dominican Republic; Mauritius; Haiti

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Unclassified	HTT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C19;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0038194; thyroid-stimulating hormone signaling pathway	3.106E-04	9.662E-01	TSHR
MF	GO:0060089; molecular transducer activity	GO:0004996; thyroid-stimulating hormone receptor activity	3.106E-04	9.662E-01	TSHR
BP	GO:0065007; biological regulation	GO:0051480; regulation of cytosolic calcium ion concentration	4.362E-02	1.000E+00	HTT
CC	GO:0044464; cell part	GO:0005770; late endosome	2.082E-02	1.000E+00	HTT
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	2.861E-02	1.000E+00	TSHR
CC	GO:0044464; cell part	GO:0030424; axon	3.939E-02	1.000E+00	HTT
CC	GO:0032991; macromolecular complex	GO:0043235; receptor complex	4.918E-02	1.000E+00	TSHR
MF	GO:0003824; catalytic activity	GO:0008392; arachidonic acid epoxygenase activity	2.638E-03	1.000E+00	CYP2C19
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	5.272E-03	1.000E+00	CYP2C19
MF	GO:0005488; binding	GO:0019825; oxygen binding	6.973E-03	1.000E+00	CYP2C19
MF	GO:0005488; binding	GO:0002039; p53 binding	1.083E-02	1.000E+00	HTT
MF	GO:0005488; binding	GO:0031072; heat shock protein binding	1.622E-02	1.000E+00	HTT

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	4.344E-03	2.100E-02	CYP2C19
09160 Human Diseases	09162 Immune diseases	hsa05320	Autoimmune thyroid disease	7.929E-03	2.100E-02	TSHR
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	8.377E-03	2.100E-02	TSHR
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	9.272E-03	2.100E-02	CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.031E-02	2.100E-02	CYP2C19
09150 Organismal Systems	09152 Endocrine system	hsa04918	Thyroid hormone synthesis	1.061E-02	2.100E-02	TSHR
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.671E-02	2.506E-02	CYP2C19
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.225E-02	2.100E-02	CYP2C19
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05016	Huntington's disease	2.867E-02	3.547E-02	HTT
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	2.956E-02	3.547E-02	TSHR

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases