CMAUP Plant Collective Molecular Activities

Plant Name: Plantago asiatica

Taxonomic Information:

Plant ID: NPO3477
Plant Latin Name: Plantago asiatica
Taxonomy Genus: Plantago
Taxonomy Family: Plantaginaceae

Plant External Links:

NCBI TaxonomyDB: 197796
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China; South Korea; India

Traditional Medicine System:

Indian Folk; TCM; Kampo

Medicinal Functions:

Antibacterial; Antiinflammatory; Antiseptic; Antitussive; Cardiac; Diuretic; Expectorant; Haemostatic; Laxative

Geographical Distribution:

India; South Korea; China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPBAR1; FFAR1; FFAR4;
Peptide receptor (family A GPCR)	TSHR;
Protein Phosphatase	PTPN1; PTPN2; ACP1; PTPRF; CDC25B;
Enzyme_unclassified	PLA2G1B; RECQL; TDP1; HSD11B1; AKR1B10; ALOX15; ALDH1A1; POLB;
Protein Kinase	PRKCA;
Lyase	CA1; CA12; CA5A; CA5B; CA6;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD; PPARG;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Nuclear hormone receptor subfamily 1 group I	NR1I2;
Oxidoreductase	PTGS1;
Metallo protease	MMP12; MMP2;
Toll-like and Il-1 receptors	TLR2;
Unclassified	HTT; LMNA; FABP3; FABP2; FABP4; FABP5;
Methyl-lysine/arginine binding protein	L3MBTL1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	PLA2G1B	Phospholipase A2 group 1B	P04054	CHEMBL4426
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	P28845	CHEMBL4235
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Metallo protease	MMP12	Matrix metalloproteinase 12	P39900	CHEMBL4393
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Methyl-lysine/arginine binding protein	L3MBTL1	Lethal(3)malignant brain tumor-like protein 1	Q9Y468	CHEMBL1287622
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Nuclear hormone receptor subfamily 1 group C	PPARG	Peroxisome proliferator-activated receptor gamma	P37231	CHEMBL235
Nuclear hormone receptor subfamily 1 group F	RORC	Nuclear receptor ROR-gamma	P51449	CHEMBL1741186
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Nuclear hormone receptor subfamily 1 group I	NR1I2	Pregnane X receptor	O75469	CHEMBL3401
Oxidoreductase	PTGS1	Cyclooxygenase-1	P23219	CHEMBL221
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Kinase	PRKCA	Protein kinase C alpha	P17252	CHEMBL299
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Protein Phosphatase	PTPN2	T-cell protein-tyrosine phosphatase	P17706	CHEMBL3807
Protein Phosphatase	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P24666	CHEMBL4903
Protein Phosphatase	PTPRF	Receptor-type tyrosine-protein phosphatase F (LAR)	P10586	CHEMBL3521
Protein Phosphatase	CDC25B	Dual specificity phosphatase Cdc25B	P30305	CHEMBL4804
Small molecule receptor (family A GPCR)	GPBAR1	G-protein coupled bile acid receptor 1	Q8TDU6	CHEMBL5409
Small molecule receptor (family A GPCR)	FFAR1	Free fatty acid receptor 1	O14842	CHEMBL4422
Small molecule receptor (family A GPCR)	FFAR4	G-protein coupled receptor 120	Q5NUL3	CHEMBL5339
Toll-like and Il-1 receptors	TLR2	Toll-like receptor 2	O60603	CHEMBL4163
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	FABP2	Fatty acid binding protein intestinal	P12104	CHEMBL4879
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	2.044E-12	1.484E-08	CA1, CA12, CA5A, CA5B, CA6, L3MBTL1, MMP12, MMP2, NR1H4, NR1I2, PPARA, PPARD, PPARG, PRKCA, PTPN1, RORC
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	8.690E-11	3.785E-07	CA1, CA12, CA5A, CA5B, CA6
MF	GO:0140110; transcription regulator activity	GO:0004879; nuclear receptor activity	6.978E-10	1.381E-06	NR1H4, NR1I2, PPARA, PPARD, PPARG, RORC
MF	GO:0060089; molecular transducer activity	GO:0003707; steroid hormone receptor activity	2.215E-09	4.019E-06	NR1H4, NR1I2, PPARA, PPARD, PPARG, RORC
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.057E-08	1.438E-05	CA1, CA12, CA5A, CA5B, CA6
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	3.008E-08	3.853E-05	CA1, CA12, CA5A, CA5B, CA6
BP	GO:0050896; response to stimulus	GO:0050728; negative regulation of inflammatory response	1.271E-07	1.258E-04	FFAR4, NR1H4, PPARA, PPARD, PPARG, PTPN2
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	1.932E-07	1.829E-04	FABP2, FABP3, FABP4, FABP5
BP	GO:0009987; cellular process	GO:0043401; steroid hormone mediated signaling pathway	2.633E-07	2.293E-04	NR1H4, NR1I2, PPARA, PPARD, PPARG, RORC
BP	GO:0050896; response to stimulus	GO:0070542; response to fatty acid	6.306E-07	4.291E-04	FABP3, FFAR1, NR1H4, PPARG, TLR2
BP	GO:0008152; metabolic process	GO:0006367; transcription initiation from RNA polymerase II promoter	8.941E-07	5.682E-04	NR1H4, NR1I2, PPARA, PPARD, PPARG, RORC
BP	GO:0009987; cellular process	GO:0030522; intracellular receptor signaling pathway	1.509E-06	7.640E-04	NR1H4, NR1I2, PPARA, PPARD, PPARG, RORC
BP	GO:0008152; metabolic process	GO:0035335; peptidyl-tyrosine dephosphorylation	1.823E-06	9.022E-04	ACP1, CDC25B, PTPN1, PTPN2, PTPRF
BP	GO:0008152; metabolic process	GO:0006631; fatty acid metabolic process	2.234E-06	9.731E-04	ALOX15, FABP3, PLA2G1B, PPARA, PPARD, PPARG, PTGS1
BP	GO:0050896; response to stimulus	GO:0032868; response to insulin	9.647E-06	3.334E-03	FABP3, PLA2G1B, PPARA, PPARG, TLR2
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	1.253E-05	4.071E-03	GPBAR1, NR1H4
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	1.253E-05	4.071E-03	GPBAR1, NR1H4
BP	GO:0008283; cell proliferation	GO:0042127; regulation of cell proliferation	1.519E-05	4.659E-03	CDC25B, FABP3, LMNA, MMP12, MMP2, PLA2G1B, PPARD, PPARG, PRKCA, PTGS1, PTPN2, TLR2, TSHR
BP	GO:0009987; cellular process	GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway	2.502E-05	6.598E-03	PTPN1, PTPN2
BP	GO:0008152; metabolic process	GO:0006691; leukotriene metabolic process	3.552E-05	8.142E-03	ALOX15, PLA2G1B, TLR2
BP	GO:0051179; localization	GO:0010891; negative regulation of sequestering of triglyceride	4.165E-05	9.254E-03	PPARA, PPARG

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	7.248E-11	8.843E-09	FABP2, FABP3, FABP4, FABP5, PPARG, PPARA, PPARD
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.501E-10	9.157E-09	CA12, CA1, CA5B, CA5A, CA6
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1.909E-04	7.762E-03	FABP4, TSHR, PTGS1
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	2.583E-04	7.877E-03	PLA2G1B, ALOX15, PTGS1
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	4.354E-04	1.062E-02	PTPN1, ACP1, PTPRF
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	1.343E-03	2.334E-02	PTPN1, PPARA, PTPRF
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.453E-03	2.334E-02	ALOX15, PRKCA, PTGS1
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	7.954E-03	8.086E-02	MMP2, PRKCA, PPARG, PPARD
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.530E-03	2.334E-02	PLA2G1B, ALOX15
09150 Organismal Systems	09154 Digestive system	hsa04975	Fat digestion and absorption	3.044E-03	4.127E-02	FABP2, PLA2G1B

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Cancer	C00-C96	CDC25B;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases