Plant Name: Goniothalamus leiocarpus
Taxonomic Information:
Plant ID: NPO3409
Plant Latin Name: Goniothalamus leiocarpus
Taxonomy Genus: Goniothalamus
Taxonomy Family: Annonaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| JAK2; | |
| KMT2A; | |
| LMNA; HTT; RAB9A; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Plant homeodomain | KMT2A | Histone-lysine N-methyltransferase MLL | Q03164 | CHEMBL1293299 |
| Protein Kinase | JAK2 | Tyrosine-protein kinase JAK2 | O60674 | CHEMBL2971 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Unclassified | HTT | Huntingtin | P42858 | CHEMBL5514 |
| Unclassified | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0005488; binding | GO:0042802; identical protein binding | 2.357E-04 | 3.523E-01 | HTT, JAK2, KMT2A, RAB9A |
| CC | GO:0044464; cell part | GO:0005770; late endosome | 4.782E-04 | 4.161E-01 | HTT, RAB9A |
| CC | GO:0044464; cell part | GO:0005829; cytosol | 9.852E-04 | 4.900E-01 | HTT, JAK2, KMT2A, LMNA, RAB9A |
| CC | GO:0043226; organelle | GO:0005654; nucleoplasm | 2.607E-03 | 5.852E-01 | HTT, JAK2, KMT2A, LMNA |
| CC | GO:0044464; cell part | GO:0005773; vacuole | 3.000E-03 | 6.221E-01 | HTT, RAB9A |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09160 Human Diseases | 09167 Infectious diseases | hsa05162 | Measles | 4.529E-04 | 9.511E-03 | RAB9A, JAK2 |
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00310 | Lysine degradation | 1.293E-02 | 4.970E-02 | KMT2A |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04917 | Prolactin signaling pathway | 1.787E-02 | 4.970E-02 | JAK2 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04920 | Adipocytokine signaling pathway | 1.738E-02 | 4.970E-02 | JAK2 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05140 | Leishmaniasis | 1.812E-02 | 4.970E-02 | JAK2 |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 2.500E-02 | 4.970E-02 | JAK2 |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 1.837E-02 | 4.970E-02 | LMNA |
| 09150 Organismal Systems | 09156 Nervous system | hsa04725 | Cholinergic synapse | 2.745E-02 | 4.970E-02 | JAK2 |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05410 | Hypertrophic cardiomyopathy (HCM) | 2.058E-02 | 4.970E-02 | LMNA |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05414 | Dilated cardiomyopathy | 2.230E-02 | 4.970E-02 | LMNA |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
