CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	ALPL; TDP1; HSD17B10;
Hydrolase	GAA;
Lyase	CA2; CA12; CA9; CA1; CA7; CA3; CA14; CA5B; CA5A; CA4; CA6;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD;
Toll-like and Il-1 receptors	TLR2;
Transcription Factor	NFKB1;
SLC superfamily of solute carriers	SLC5A1; SLC5A2; SLC5A4;
Unclassified	HTT; FABP2; FABP3; FABP5; FABP4;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	5.070E-08	5.810E-05	FABP2, FABP3, FABP4, FABP5
BP	Unclassified;	GO:0015758; glucose transport	6.399E-07	5.806E-04	PPARD, SLC5A1, SLC5A2, SLC5A4
BP	Unclassified;	GO:0035428; hexose transmembrane transport	4.596E-06	2.944E-03	SLC5A1, SLC5A2, SLC5A4
BP	GO:0051179; localization	GO:1904659; glucose transmembrane transport	4.596E-06	2.944E-03	SLC5A1, SLC5A2, SLC5A4
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	6.523E-06	3.689E-03	CA2, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	7.393E-23	8.049E-19	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.502E-21	1.362E-17	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	7.645E-10	1.110E-06	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, PPARA, PPARD
MF	GO:0005215; transporter activity	GO:0005412; glucose:sodium symporter activity	6.067E-08	6.605E-05	SLC5A1, SLC5A2, SLC5A4
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.349E-29	2.937E-25	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	8.327E-29	7.245E-27	CA12, CA1, CA3, CA5B, CA2, CA5A, CA4, CA7, CA6, CA9, CA14
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	2.930E-03	3.354E-02	PPARA, NFKB1, TSHR
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	6.024E-10	2.621E-08	FABP2, FABP3, FABP4, FABP5, PPARA, PPARD
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	1.466E-04	4.252E-03	CA2, SLC5A1, CYP3A4
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	5.040E-04	1.096E-02	CA2, CA4
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2.978E-03	3.354E-02	FABP4, TSHR
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	2.874E-03	3.354E-02	NFKB1, TLR2
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	3.084E-03	3.354E-02	NFKB1, PPARD
09160 Human Diseases	09162 Immune diseases	hsa05321	Inflammatory bowel disease (IBD)	3.990E-03	3.857E-02	NFKB1, TLR2
09160 Human Diseases	09167 Infectious diseases	hsa05140	Leishmaniasis	5.006E-03	3.959E-02	NFKB1, TLR2

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Anthelmintic	B89	ALPL;
C00-D49: Neoplasms	Colon cancer	C50	ALPL;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 1 diabetes	E10	SLC5A2;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1; SLC5A4; SLC5A1; SLC5A2;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	SLC5A4; SLC5A1; SLC5A2;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 1/2 diabetes	E08-E13	SLC5A4;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Alstonia undulifolia

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities