Plant ID: NPO3376
Plant Latin Name: Eriostemon brucei
Taxonomy Genus: Eriostemon
Taxonomy Family: Rutaceae
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
GPBAR1; | |
PTPN1; PTPN2; ACP1; PTPRF; CDC25B; | |
RECQL; PLA2G1B; HPGD; HSD11B1; AKR1B10; HSD17B10; ALDH1A1; POLB; | |
BCL2; | |
LCK; LIMK1; | |
RORC; | |
NR1H4; | |
CASP1; CASP7; | |
MCL1; |
Cytochrome P450 Enzymes: |
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Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|
Cysteine protease | CASP1 | Caspase-1 | P29466 | CHEMBL4801 |
Cysteine protease | CASP7 | Caspase-7 | P55210 | CHEMBL3468 |
Enzyme_unclassified | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
Enzyme_unclassified | PLA2G1B | Phospholipase A2 group 1B | P04054 | CHEMBL4426 |
Enzyme_unclassified | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD+] | P15428 | CHEMBL1293255 |
Enzyme_unclassified | HSD11B1 | 11-beta-hydroxysteroid dehydrogenase 1 | P28845 | CHEMBL4235 |
Enzyme_unclassified | AKR1B10 | Aldo-keto reductase family 1 member B10 | O60218 | CHEMBL5983 |
Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
Enzyme_unclassified | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
Miscellaneous ion channel | BCL2 | Apoptosis regulator Bcl-2 | P10415 | CHEMBL4860 |
Nuclear hormone receptor subfamily 1 group F | RORC | Nuclear receptor ROR-gamma | P51449 | CHEMBL1741186 |
Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
Protein Kinase | LCK | Tyrosine-protein kinase LCK | P06239 | CHEMBL258 |
Protein Kinase | LIMK1 | LIM domain kinase 1 | P53667 | CHEMBL3836 |
Protein Phosphatase | PTPN1 | Protein-tyrosine phosphatase 1B | P18031 | CHEMBL335 |
Protein Phosphatase | PTPN2 | T-cell protein-tyrosine phosphatase | P17706 | CHEMBL3807 |
Protein Phosphatase | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | P24666 | CHEMBL4903 |
Protein Phosphatase | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | P10586 | CHEMBL3521 |
Protein Phosphatase | CDC25B | Dual specificity phosphatase Cdc25B | P30305 | CHEMBL4804 |
Small molecule receptor (family A GPCR) | GPBAR1 | G-protein coupled bile acid receptor 1 | Q8TDU6 | CHEMBL5409 |
Unclassified | MCL1 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Q07820 | CHEMBL4361 |
GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|
BP | GO:0008152; metabolic process | GO:0035335; peptidyl-tyrosine dephosphorylation | 7.849E-08 | 3.972E-04 | ACP1, CDC25B, PTPN1, PTPN2, PTPRF |
BP | GO:0009987; cellular process | GO:2001244; positive regulation of intrinsic apoptotic signaling pathway | 4.457E-07 | 1.417E-03 | BCL2, LCK, MCL1, PTPN2 |
BP | GO:0019740; nitrogen utilization | GO:0006808; regulation of nitrogen utilization | 3.712E-06 | 5.389E-03 | BCL2, NR1H4 |
BP | GO:0009987; cellular process | GO:0038183; bile acid signaling pathway | 3.712E-06 | 5.389E-03 | GPBAR1, NR1H4 |
MF | GO:0060089; molecular transducer activity | GO:0038181; bile acid receptor activity | 3.712E-06 | 5.389E-03 | GPBAR1, NR1H4 |
BP | GO:0002376; immune system process | GO:0030217; T cell differentiation | 4.424E-06 | 5.723E-03 | BCL2, LCK, PTPN2, RORC |
BP | GO:0009987; cellular process | GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway | 7.420E-06 | 8.503E-03 | PTPN1, PTPN2 |
MF | GO:0003824; catalytic activity | GO:0003824; catalytic activity | 9.001E-06 | 9.533E-03 | ACP1, AKR1B10, ALDH1A1, CASP1, CASP7, CDC25B, HPGD, HSD11B1, HSD17B10, LCK, LIMK1, PLA2G1B, POLB, PTPN1, PTPN2, PTPRF, RECQL |
MF | GO:0003824; catalytic activity | GO:0016616; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | 9.193E-06 | 9.533E-03 | AKR1B10, HPGD, HSD11B1, HSD17B10 |
MF | GO:0005488; binding | GO:0051434; BH3 domain binding | 1.236E-05 | 1.223E-02 | BCL2, MCL1 |
MF | GO:0003824; catalytic activity | GO:0001758; retinal dehydrogenase activity | 2.591E-05 | 1.946E-02 | AKR1B10, ALDH1A1 |
Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|---|
09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04520 | Adherens junction | 7.119E-05 | 5.054E-03 | PTPN1, ACP1, PTPRF |
09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 4.690E-04 | 1.579E-02 | CASP7, BCL2, MCL1 |
09130 Environmental Information Processing | 09132 Signal transduction | hsa04630 | Jak-STAT signaling pathway | 6.671E-04 | 1.579E-02 | BCL2, PTPN2, MCL1 |
09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05014 | Amyotrophic lateral sclerosis (ALS) | 1.425E-03 | 2.351E-02 | BCL2, CASP1 |
09160 Human Diseases | 09167 Infectious diseases | hsa05134 | Legionellosis | 1.656E-03 | 2.351E-02 | CASP7, CASP1 |
09160 Human Diseases | 09161 Cancers | hsa05206 | MicroRNAs in cancer | 4.050E-03 | 4.108E-02 | BCL2, CDC25B, MCL1 |
09160 Human Diseases | 09167 Infectious diseases | hsa05133 | Pertussis | 3.053E-03 | 3.613E-02 | CASP7, CASP1 |
09130 Environmental Information Processing | 09132 Signal transduction | hsa04064 | NF-kappa B signaling pathway | 4.651E-03 | 4.128E-02 | LCK, BCL2 |
09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04931 | Insulin resistance | 6.332E-03 | 4.995E-02 | PTPN1, PTPRF |
09150 Organismal Systems | 09152 Endocrine system | hsa04910 | Insulin signaling pathway | 1.011E-02 | 6.528E-02 | PTPN1, PTPRF |
ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
---|---|---|---|
C00-D49: Neoplasms | Multiple myeloma | C90 | BCL2; |
C00-D49: Neoplasms | Chronic lymphocytic leukaemia | C91 | BCL2; |
L00-L99: Diseases of the skin and subcutaneous tissue | Psoriasis | L40 | BCL2; |
C00-D49: Neoplasms | Prostate cancer | C61 | BCL2; |
E00-E89: Endocrine, nutritional and metabolic diseases | Autoimmune diabetes | E08-E13 | LCK; |
C00-D49: Neoplasms | Cancer | C00-C96 | MCL1; CDC25B; BCL2; |
C00-D49: Neoplasms | Advanced melanoma | C43 | BCL2; |
C00-D49: Neoplasms | Breast cancer | C50 | BCL2; |
C00-D49: Neoplasms | Leukemia | C90-C95 | BCL2; |
G00-G99: Diseases of the nervous system G00-G99 | Amyotrophic lateral sclerosis | G12.2 | BCL2; |
C00-D49: Neoplasms | Lymphoma | C81-C86 | BCL2; |