CMAUP Plant Collective Molecular Activities

Plant Name: Murraya koenigii

Taxonomic Information:

Plant ID: NPO3364
Plant Latin Name: Murraya koenigii
Taxonomy Genus: Murraya
Taxonomy Family: Rutaceae

Plant External Links:

NCBI TaxonomyDB: 159030
Plant-of-the-World-Online: 774433-1

Used in Medicines:

Country/Region:

Nigeria; India

Traditional Medicine System:

Geographical Distribution:

Maldives; Bangladesh; India; Cambodia; Vietnam; Laos; Thailand; Nigeria; Fiji

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Kinase	ATM;
Unclassified	NPC1; XBP1; RAB9A;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Protein Kinase	ATM	Serine-protein kinase ATM	Q13315	CHEMBL3797
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	XBP1	X-box-binding protein 1	P17861	CHEMBL1741176
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0010506; regulation of autophagy	1.572E-05	3.422E-01	ATM, NPC1, XBP1
BP	GO:0065007; biological regulation	GO:0042632; cholesterol homeostasis	6.869E-05	4.099E-01	NPC1, XBP1
BP	GO:0071840; cellular component organization or biogenesis	GO:1904884; positive regulation of telomerase catalytic core complex assembly	4.141E-04	4.099E-01	ATM
CC	GO:0044464; cell part	GO:0005764; lysosome	1.180E-03	6.111E-01	NPC1, RAB9A
MF	GO:0005488; binding	GO:0036094; small molecule binding	7.257E-03	9.188E-01	ATM, NPC1, RAB9A
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	1.278E-02	1.000E+00	RAB9A, XBP1
CC	GO:0044464; cell part	GO:0005783; endoplasmic reticulum	1.340E-02	1.000E+00	NPC1, XBP1
CC	GO:0044464; cell part	GO:0005635; nuclear envelope	3.333E-02	1.000E+00	NPC1
MF	GO:0005488; binding	GO:0001047; core promoter binding	3.434E-02	1.000E+00	XBP1
MF	GO:0005488; binding	GO:0035639; purine ribonucleoside triphosphate binding	4.646E-02	1.000E+00	ATM, RAB9A

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09167 Infectious diseases	hsa05166	HTLV-I infection	9.777E-04	1.173E-02	XBP1, ATM
09140 Cellular Processes	09143 Cell growth and death	hsa04115	p53 signaling pathway	1.373E-02	3.875E-02	ATM
09130 Environmental Information Processing	09132 Signal transduction	hsa04064	NF-kappa B signaling pathway	1.847E-02	3.875E-02	ATM
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	2.771E-02	3.875E-02	ATM
09140 Cellular Processes	09141 Transport and catabolism	hsa04142	Lysosome	2.438E-02	3.875E-02	NPC1
09130 Environmental Information Processing	09132 Signal transduction	hsa04068	FoxO signaling pathway	2.634E-02	3.875E-02	ATM
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04932	Non-alcoholic fatty liver disease (NAFLD)	2.986E-02	3.875E-02	XBP1
09140 Cellular Processes	09143 Cell growth and death	hsa04110	Cell cycle	2.457E-02	3.875E-02	ATM
09120 Genetic Information Processing	09123 Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	3.338E-02	3.875E-02	XBP1
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	3.552E-02	3.875E-02	ATM

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases