Plant Name: Asteraceae
Taxonomic Information:
Plant ID: NPO33469
Plant Latin Name: Asteraceae
Taxonomy Genus: NA
Taxonomy Family: Asteraceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| GPR55; | |
| TERT; | |
| PTGS2; | |
| MDM2; | |
| XBP1; MAPT; HTT; PAX8; RAB9A; NPC1; | |
| SMN1;SMN2; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | TERT | Telomerase reverse transcriptase | O14746 | CHEMBL2916 |
| Methyl-lysine/arginine binding protein | SMN1;SMN2 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
| Oxidoreductase | PTGS2 | Cyclooxygenase-2 | P35354 | CHEMBL230 |
| Small molecule receptor (family A GPCR) | GPR55 | G-protein coupled receptor 55 | Q9Y2T6 | CHEMBL1075322 |
| Transferase | MDM2 | p53-binding protein Mdm-2 | Q00987 | CHEMBL5023 |
| Unclassified | XBP1 | X-box-binding protein 1 | P17861 | CHEMBL1741176 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
| Unclassified | HTT | Huntingtin | P42858 | CHEMBL5514 |
| Unclassified | PAX8 | Paired box protein Pax-8 | Q06710 | CHEMBL2362980 |
| Unclassified | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
| Unclassified | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0005488; binding | GO:0042802; identical protein binding | 9.190E-07 | 5.318E-03 | HTT, MAPT, MDM2, PTGS2, RAB9A, SMN1, SMN2, TERT |
| BP | GO:0065007; biological regulation | GO:0031648; protein destabilization | 2.074E-06 | 7.439E-03 | HTT, MDM2, XBP1 |
| BP | GO:0009987; cellular process | GO:0031670; cellular response to nutrient | 2.392E-06 | 7.439E-03 | MDM2, PTGS2, XBP1 |
| BP | GO:0050896; response to stimulus | GO:0009750; response to fructose | 9.886E-06 | 1.593E-02 | PTGS2, XBP1 |
| BP | GO:0051179; localization | GO:0051050; positive regulation of transport | 1.097E-05 | 1.593E-02 | HTT, MDM2, PTGS2, RAB9A, TERT, XBP1 |
| MF | GO:0005488; binding | GO:0034452; dynactin binding | 1.940E-05 | 2.112E-02 | HTT, MAPT |
| CC | GO:0043226; organelle | GO:0097504; Gemini of coiled bodies | 2.327E-05 | 2.303E-02 | SMN1, SMN2 |
| CC | GO:0032991; macromolecular complex | GO:0032797; SMN complex | 2.749E-05 | 2.346E-02 | SMN1, SMN2 |
| CC | GO:0044464; cell part | GO:0034719; SMN-Sm protein complex | 5.383E-05 | 3.085E-02 | SMN1, SMN2 |
| CC | GO:0044464; cell part | GO:0043005; neuron projection | 7.254E-05 | 3.761E-02 | HTT, MAPT, PTGS2, SMN1, SMN2 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09160 Human Diseases | 09161 Cancers | hsa05200 | Pathways in cancer | 1.495E-03 | 6.277E-02 | PAX8, MDM2, PTGS2 |
| 09120 Genetic Information Processing | 09122 Translation | hsa03013 | RNA transport | 4.586E-03 | 7.014E-02 | SMN2, SMN1 |
| 09160 Human Diseases | 09161 Cancers | hsa05202 | Transcriptional misregulation in cancer | 5.010E-03 | 7.014E-02 | PAX8, MDM2 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05166 | HTLV-I infection | 1.005E-02 | 1.055E-01 | XBP1, TERT |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04370 | VEGF signaling pathway | 3.600E-02 | 1.061E-01 | PTGS2 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04923 | Regulation of lipolysis in adipocytes | 3.310E-02 | 1.061E-01 | PTGS2 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00590 | Arachidonic acid metabolism | 3.658E-02 | 1.061E-01 | PTGS2 |
| 09160 Human Diseases | 09161 Cancers | hsa05218 | Melanoma | 4.179E-02 | 1.061E-01 | MDM2 |
| 09160 Human Diseases | 09161 Cancers | hsa05220 | Chronic myeloid leukemia | 4.294E-02 | 1.061E-01 | MDM2 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04918 | Thyroid hormone synthesis | 4.179E-02 | 1.061E-01 | PAX8 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | RAB9A; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Knee osteoarthritis | M15-M19, M47 | PTGS2; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Hyperthermia | T68 | PTGS2; |
| N00-N99: Diseases of the genitourinary system | Dysmenorrhea | N94.4-N94.6 | PTGS2; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Gout | M10 | PTGS2; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Inflammation | E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89 | PTGS2; |
| K00-K95: Diseases of the digestive system | Inflammatory bowel disease | K50, K51 | PTGS2; |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | PTGS2; |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Chronic pain | R52.1-R52.2, G89 | PTGS2; |
| NA: NA | Joint and muscular pain | NA | PTGS2; |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | MDM2; |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | MDM2; |
| NA: NA | Rheumatold arthritis | NA | PTGS2; |
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | PTGS2; |
| N00-N99: Diseases of the genitourinary system | Endometriosis | N80 | PTGS2; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Ankylosing spondylitis | M08.1, M45 | PTGS2; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | MDM2; |
| G00-G99: Diseases of the nervous system G00-G99 | Spinal muscular atrophy | G00-G99 | SMN1;SMN2; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | PTGS2; |
| J00-J99: Diseases of the respiratory system | Asthma | J45 | PTGS2; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Arthritis | M00-M25 | PTGS2; |
| C00-D49: Neoplasms | Prostate cancer | C61 | MDM2; |
| K00-K95: Diseases of the digestive system | Colon polyps | K63.5 | PTGS2; |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | PTGS2; MDM2; |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | PTGS2; |
| G00-G99: Diseases of the nervous system G00-G99 | Neuropathic pain | G64, G90.0 | PTGS2; |
| C00-D49: Neoplasms | Cancer | C00-C96 | PTGS2; MDM2; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Osteoarthritis | M15-M19, M47 | PTGS2; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | PTGS2; |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | PTGS2; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Moderate to severe rheumatoid arthritis | M05-M06 | PTGS2; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
