CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Hydrolase	GAA; MGAM;
Enzyme_unclassified	GANC; SI; AGL;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	GANC	Neutral alpha-glucosidase C	Q8TET4	CHEMBL2520
Enzyme_unclassified	SI	Sucrase-isomaltase	P14410	CHEMBL2748
Enzyme_unclassified	AGL	Glycogen debranching enzyme	P35573	CHEMBL5272
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Hydrolase	MGAM	Maltase-glucoamylase	O43451	CHEMBL2074

Showing 1 to 5 of 5 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0000023; maltose metabolic process	8.327E-12	3.022E-08	GAA, GANC, MGAM
BP	GO:0032501; multicellular organismal process	GO:0044245; polysaccharide digestion	8.038E-07	7.955E-04	MGAM, SI
MF	GO:0003824; catalytic activity	GO:0032450; maltose alpha-glucosidase activity	8.327E-12	3.022E-08	GAA, GANC, MGAM
MF	GO:0003824; catalytic activity	GO:0004574; oligo-1,6-glucosidase activity	5.361E-08	7.296E-05	GAA, SI
MF	GO:0003824; catalytic activity	GO:0004558; alpha-1,4-glucosidase activity	8.623E-16	6.259E-12	GAA, GANC, MGAM, SI

Showing 1 to 5 of 5 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09101 Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1.433E-13	7.166E-13	MGAM, AGL, GAA, SI, GANC
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	2.054E-11	5.135E-11	MGAM, GAA, SI, GANC
09140 Cellular Processes	09141 Transport and catabolism	hsa04142	Lysosome	3.038E-02	3.038E-02	GAA
09150 Organismal Systems	09154 Digestive system	hsa04973	Carbohydrate digestion and absorption	4.929E-05	6.161E-05	MGAM, SI
Unclassified	Unclassified	hsa01100	Metabolic pathways	9.056E-07	1.509E-06	MGAM, SI, GAA, AGL, GANC

Showing 1 to 5 of 5 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Dengue fever	A90	MGAM;
A00-B99: Certain infectious and parasitic diseases	Acquired immune deficiency syndrome	B20	MGAM;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	MGAM;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	MGAM;
E00-E89: Endocrine, nutritional and metabolic diseases	Pompe's disease	E74.02	MGAM; GAA;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	MGAM;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Muscle disease	M60-M63	MGAM;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Hyperglycemia	R73.9	MGAM;

Showing 1 to 8 of 8 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: aglaonema treubii

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities