CMAUP Plant Collective Molecular Activities

Plant Name: sarracenia purpurea

Taxonomic Information:

Plant ID: NPO33136
Plant Latin Name: sarracenia purpurea
Taxonomy Genus: Sarracenia
Taxonomy Family: Sarraceniaceae

Plant External Links:

NCBI TaxonomyDB: 45176
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Canada

Traditional Medicine System:

Medicinal Functions:

Diuretic; Hepatic; Kidney; Laxative; Oxytoxic; Stomachic; Tonic; Women's complaints

Geographical Distribution:

Canada

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	AKR1B1; POLB;
Lysine demethylase	KDM4E;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0006286; base-excision repair, base-free sugar-phosphate removal	3.106E-04	6.149E-01	POLB
CC	GO:0043226; organelle	GO:0005876; spindle microtubule	8.209E-03	1.000E+00	POLB
CC	GO:0044464; cell part	GO:0032838; plasma membrane bounded cell projection cytoplasm	1.037E-02	1.000E+00	AKR1B1
MF	Unclassified;	GO:0003906; DNA-(apurinic or apyrimidinic site) lyase activity	2.018E-03	1.000E+00	POLB
MF	GO:0003824; catalytic activity	GO:0032454; histone demethylase activity (H3-K9 specific)	2.173E-03	1.000E+00	KDM4E
MF	GO:0003824; catalytic activity	GO:0016491; oxidoreductase activity	4.172E-03	1.000E+00	AKR1B1, KDM4E

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09101 Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	5.391E-03	1.078E-02	AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	4.493E-03	1.078E-02	AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	4.793E-03	1.078E-02	AKR1B1
09100 Metabolism	09103 Lipid metabolism	hsa00561	Glycerolipid metabolism	8.824E-03	1.412E-02	AKR1B1
09120 Genetic Information Processing	09124 Replication and repair	hsa03410	Base excision repair	4.942E-03	1.078E-02	POLB
09160 Human Diseases	09161 Cancers	hsa05203	Viral carcinogenesis	3.044E-02	4.058E-02	POLB
09160 Human Diseases	09167 Infectious diseases	hsa05166	HTLV-I infection	3.820E-02	4.366E-02	POLB
Unclassified	Unclassified	hsa01100	Metabolic pathways	1.746E-01	1.746E-01	AKR1B1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases