CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Kinase	MAPK1;
Enzyme_unclassified	ALOX15;
Lysine demethylase	KDM4E;
Transcription Factor	TP53;
Bromodomain	EP300;
Unclassified	MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Bromodomain	EP300	Histone acetyltransferase p300	Q09472	CHEMBL3784
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Showing 1 to 6 of 6 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:1900034; regulation of cellular response to heat	1.256E-06	2.735E-02	EP300, MAPK1, MAPT
BP	GO:0009987; cellular process	GO:0010638; positive regulation of organelle organization	1.460E-05	7.864E-02	ALOX15, MAPK1, MAPT, TP53
BP	GO:0009987; cellular process	GO:0031334; positive regulation of protein complex assembly	3.040E-05	8.853E-02	ALOX15, MAPT, TP53
BP	GO:0009987; cellular process	GO:0072422; signal transduction involved in DNA damage checkpoint	2.268E-04	1.066E-01	EP300, TP53
BP	GO:0050896; response to stimulus	GO:0042060; wound healing	2.329E-04	1.066E-01	ALOX15, TP53
BP	GO:0009987; cellular process	GO:0072395; signal transduction involved in cell cycle checkpoint	2.329E-04	1.066E-01	EP300, TP53
BP	GO:0009987; cellular process	GO:1901216; positive regulation of neuron death	2.329E-04	1.066E-01	MAPT, TP53
CC	GO:0044464; cell part	GO:0032838; plasma membrane bounded cell projection cytoplasm	1.762E-04	1.066E-01	MAPK1, MAPT
CC	GO:0044464; cell part	GO:0030424; axon	2.553E-03	2.505E-01	MAPK1, MAPT
MF	GO:0005488; binding	GO:0019902; phosphatase binding	1.180E-05	7.864E-02	MAPK1, MAPT, TP53

Showing 1 to 10 of 14 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	3.982E-05	6.969E-04	MAPK1, MAPT, TP53
09130 Environmental Information Processing	09132 Signal transduction	hsa04350	TGF-beta signaling pathway	2.586E-04	1.293E-03	EP300, MAPK1
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	3.887E-04	1.775E-03	EP300, MAPK1
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	5.272E-04	2.129E-03	MAPK1, TP53
09130 Environmental Information Processing	09132 Signal transduction	hsa04068	FoxO signaling pathway	6.470E-04	2.342E-03	EP300, MAPK1
09130 Environmental Information Processing	09132 Signal transduction	hsa04310	Wnt signaling pathway	7.370E-04	2.496E-03	EP300, TP53
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	1.439E-03	4.031E-03	EP300, MAPK1
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	2.006E-04	1.053E-03	EP300, MAPK1
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	7.165E-04	2.496E-03	MAPK1, TP53
09140 Cellular Processes	09143 Cell growth and death	hsa04110	Cell cycle	5.627E-04	2.188E-03	EP300, TP53

Showing 1 to 10 of 40 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: barleria alluaudii

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities