CMAUP Plant Collective Molecular Activities

Plant Name: barleria alluaudii

Taxonomic Information:

Plant ID: NPO33133
Plant Latin Name: barleria alluaudii
Taxonomy Genus: Barleria
Taxonomy Family: Acanthaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Kinase	MAPK1;
Enzyme_unclassified	ALOX15;
Lysine demethylase	KDM4E;
Transcription Factor	TP53;
Bromodomain	EP300;
Unclassified	MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Bromodomain	EP300	Histone acetyltransferase p300	Q09472	CHEMBL3784
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:1900034; regulation of cellular response to heat	1.256E-06	2.735E-02	EP300, MAPK1, MAPT
BP	GO:0009987; cellular process	GO:0010638; positive regulation of organelle organization	1.460E-05	7.864E-02	ALOX15, MAPK1, MAPT, TP53
MF	GO:0005488; binding	GO:0019902; phosphatase binding	1.180E-05	7.864E-02	MAPK1, MAPT, TP53
BP	GO:0009987; cellular process	GO:0031334; positive regulation of protein complex assembly	3.040E-05	8.853E-02	ALOX15, MAPT, TP53
MF	GO:0005488; binding	GO:0051721; protein phosphatase 2A binding	3.029E-05	8.853E-02	MAPT, TP53
BP	GO:0009987; cellular process	GO:0072422; signal transduction involved in DNA damage checkpoint	2.268E-04	1.066E-01	EP300, TP53
BP	GO:0050896; response to stimulus	GO:0042060; wound healing	2.329E-04	1.066E-01	ALOX15, TP53
BP	GO:0009987; cellular process	GO:0072395; signal transduction involved in cell cycle checkpoint	2.329E-04	1.066E-01	EP300, TP53
BP	GO:0009987; cellular process	GO:1901216; positive regulation of neuron death	2.329E-04	1.066E-01	MAPT, TP53
CC	GO:0044464; cell part	GO:0032838; plasma membrane bounded cell projection cytoplasm	1.762E-04	1.066E-01	MAPK1, MAPT
MF	GO:0005488; binding	GO:0003684; damaged DNA binding	1.762E-04	1.066E-01	EP300, TP53
MF	GO:0005488; binding	GO:0002039; p53 binding	1.924E-04	1.066E-01	EP300, TP53
MF	GO:0003824; catalytic activity	GO:0051213; dioxygenase activity	3.181E-04	1.066E-01	ALOX15, KDM4E
CC	GO:0044464; cell part	GO:0030424; axon	2.553E-03	2.505E-01	MAPK1, MAPT

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	1.687E-06	1.772E-04	EP300, MAPK1, TP53
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	3.953E-06	2.075E-04	EP300, MAPK1, TP53
09160 Human Diseases	09167 Infectious diseases	hsa05161	Hepatitis B	7.500E-06	2.625E-04	EP300, MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05203	Viral carcinogenesis	2.075E-05	5.446E-04	EP300, MAPK1, TP53
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	3.982E-05	6.969E-04	MAPK1, MAPT, TP53
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	6.272E-05	8.233E-04	EP300, MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05216	Thyroid cancer	3.034E-05	6.372E-04	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	1.485E-04	1.015E-03	EP300, MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05223	Non-small cell lung cancer	1.147E-04	1.015E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	6.118E-05	8.233E-04	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05213	Endometrial cancer	9.879E-05	1.015E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05214	Glioma	1.547E-04	1.015E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05210	Colorectal cancer	1.407E-04	1.015E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	1.595E-04	1.015E-03	MAPK1, TP53
09150 Organismal Systems	09156 Nervous system	hsa04720	Long-term potentiation	1.595E-04	1.015E-03	EP300, MAPK1
09160 Human Diseases	09161 Cancers	hsa05211	Renal cell carcinoma	1.595E-04	1.015E-03	EP300, MAPK1
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	1.847E-04	1.053E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	1.644E-04	1.015E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	1.953E-04	1.053E-03	MAPK1, TP53
09150 Organismal Systems	09152 Endocrine system	hsa04916	Melanogenesis	3.664E-04	1.749E-03	EP300, MAPK1
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	2.006E-04	1.053E-03	EP300, MAPK1
09130 Environmental Information Processing	09132 Signal transduction	hsa04350	TGF-beta signaling pathway	2.586E-04	1.293E-03	EP300, MAPK1
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	3.887E-04	1.775E-03	EP300, MAPK1
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	4.594E-04	2.010E-03	ALOX15, MAPK1
09150 Organismal Systems	09156 Nervous system	hsa04722	Neurotrophin signaling pathway	5.272E-04	2.129E-03	MAPK1, TP53
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	7.165E-04	2.496E-03	MAPK1, TP53
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	5.272E-04	2.129E-03	MAPK1, TP53
09130 Environmental Information Processing	09132 Signal transduction	hsa04068	FoxO signaling pathway	6.470E-04	2.342E-03	EP300, MAPK1
09160 Human Diseases	09167 Infectious diseases	hsa05160	Hepatitis C	6.470E-04	2.342E-03	MAPK1, TP53
09130 Environmental Information Processing	09132 Signal transduction	hsa04310	Wnt signaling pathway	7.370E-04	2.496E-03	EP300, TP53
09140 Cellular Processes	09143 Cell growth and death	hsa04110	Cell cycle	5.627E-04	2.188E-03	EP300, TP53
09160 Human Diseases	09167 Infectious diseases	hsa05164	Influenza A	1.116E-03	3.550E-03	EP300, MAPK1
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	1.029E-03	3.377E-03	MAPK1, MAPT
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05016	Huntington's disease	1.355E-03	3.951E-03	EP300, TP53
09160 Human Diseases	09167 Infectious diseases	hsa05152	Tuberculosis	1.154E-03	3.564E-03	EP300, MAPK1
09160 Human Diseases	09167 Infectious diseases	hsa05169	Epstein-Barr virus infection	1.482E-03	4.031E-03	EP300, TP53
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	1.497E-03	4.031E-03	MAPK1, TP53
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	1.439E-03	4.031E-03	EP300, MAPK1
09160 Human Diseases	09167 Infectious diseases	hsa05168	Herpes simplex infection	1.246E-03	3.737E-03	EP300, TP53
09160 Human Diseases	09167 Infectious diseases	hsa05166	HTLV-I infection	2.403E-03	6.308E-03	EP300, TP53

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases