Plant Name: boswellia spp.
Taxonomic Information:
Plant ID: NPO33055
Plant Latin Name: boswellia spp.
Taxonomy Genus: Boswellia
Taxonomy Family: Burseraceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| PTPN1; PTPN2; | |
| PTGES; | |
| NR1H4; | |
| ALOX5; | |
| PREP; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | PTGES | Prostaglandin E synthase | O14684 | CHEMBL5658 |
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Oxidoreductase | ALOX5 | Arachidonate 5-lipoxygenase | P09917 | CHEMBL215 |
| Protein Phosphatase | PTPN1 | Protein-tyrosine phosphatase 1B | P18031 | CHEMBL335 |
| Protein Phosphatase | PTPN2 | T-cell protein-tyrosine phosphatase | P17706 | CHEMBL3807 |
| Serine protease | PREP | Prolyl endopeptidase | P48147 | CHEMBL3202 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway | 4.823E-07 | 5.251E-03 | PTPN1, PTPN2 |
| CC | GO:0044464; cell part | GO:0005641; nuclear envelope lumen | 2.250E-06 | 1.225E-02 | ALOX5, PTGES |
| BP | GO:0009987; cellular process | GO:1903897; regulation of PERK-mediated unfolded protein response | 3.614E-06 | 1.574E-02 | PTPN1, PTPN2 |
| BP | GO:0009987; cellular process | GO:1900103; positive regulation of endoplasmic reticulum unfolded protein response | 6.262E-06 | 2.273E-02 | PTPN1, PTPN2 |
| BP | GO:0009987; cellular process | GO:0001959; regulation of cytokine-mediated signaling pathway | 1.245E-05 | 3.687E-02 | NR1H4, PTPN1, PTPN2 |
| BP | GO:0009987; cellular process | GO:0010804; negative regulation of tumor necrosis factor-mediated signaling pathway | 1.524E-05 | 3.687E-02 | NR1H4, PTPN2 |
| BP | GO:0050896; response to stimulus | GO:0046627; negative regulation of insulin receptor signaling pathway | 3.484E-05 | 6.758E-02 | PTPN1, PTPN2 |
| MF | GO:0005488; binding | GO:0030971; receptor tyrosine kinase binding | 1.229E-04 | 1.301E-01 | PTPN1, PTPN2 |
| MF | GO:0003824; catalytic activity | GO:0004725; protein tyrosine phosphatase activity | 4.085E-04 | 1.588E-01 | PTPN1, PTPN2 |
| MF | GO:0060089; molecular transducer activity | GO:0038181; bile acid receptor activity | 9.316E-04 | 2.657E-01 | NR1H4 |
| CC | GO:0044464; cell part | GO:0097443; sorting endosome | 1.863E-03 | 3.976E-01 | PTPN1 |
| MF | GO:0005488; binding | GO:0097677; STAT family protein binding | 1.863E-03 | 3.976E-01 | PTPN2 |
| MF | GO:0060089; molecular transducer activity | GO:0004887; thyroid hormone receptor activity | 2.173E-03 | 4.340E-01 | NR1H4 |
| CC | GO:0016020; membrane | GO:0016020; membrane | 4.213E-02 | 1.000E+00 | ALOX5, PREP, PTGES, PTPN1, PTPN2 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09103 Lipid metabolism | hsa00590 | Arachidonic acid metabolism | 1.407E-04 | 1.548E-03 | ALOX5, PTGES |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04614 | Renin-angiotensin system | 6.881E-03 | 3.785E-02 | PREP |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04913 | Ovarian steroidogenesis | 1.491E-02 | 4.797E-02 | ALOX5 |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04520 | Adherens junction | 2.200E-02 | 4.797E-02 | PTPN1 |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 2.111E-02 | 4.797E-02 | NR1H4 |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04931 | Insulin resistance | 3.226E-02 | 4.797E-02 | PTPN1 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 3.314E-02 | 4.797E-02 | ALOX5 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05145 | Toxoplasmosis | 3.489E-02 | 4.797E-02 | ALOX5 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04630 | Jak-STAT signaling pathway | 4.648E-02 | 4.867E-02 | PTPN2 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04910 | Insulin signaling pathway | 4.099E-02 | 4.867E-02 | PTPN1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | PTGES; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
